Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods

Autor: Tresa López-Royo, Víctor Sebastián, Laura Moreno-Martínez, Laura Uson, Cristina Yus, Teresa Alejo, Pilar Zaragoza, Rosario Osta, Manuel Arruebo, Raquel Manzano

Publikováno v: Nanomaterials, Vol 11, Iss 10, p 2723 (2021)

The development of new gene-editing technologies has fostered the need for efficient and safe vectors capable of encapsulating large nucleic acids. In this work we evaluate the synthesis of large-size plasmid-loaded PLGA nanoparticles by double emuls

Externí odkaz: https://doaj.org/article/7280452fcab64166b47917b4fba12ee7

Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease

Autor: Inmaculada Martín-Burriel, Óscar López-Pérez, Juan José Badiola, Marina Betancor, Alicia Otero, Laura Moreno-Martínez, Rosa Bolea, Rosario Osta, Adelaida Hernaiz, Tomás Barrio

Publikováno v: Molecular Neurobiology
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Molecular Neurobiology, 2021, 58 (10), pp.5312-5326. ⟨10.1007/s12035-021-02489-5⟩
Molecular Neurobiology, Humana Press, 2021, 58 (10), pp.5312-5326. ⟨10.1007/s12035-021-02489-5⟩
Dipòsit Digital de la UB
Universidad de Barcelona

The non-toxic C-terminal fragment of the tetanus toxin (TTC) has been described as a neuroprotective molecule since it binds to Trk receptors and activates Trk-dependent signaling, activating neuronal survival pathways and inhibiting apoptosis. Previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0389760909b52992bc0f55a5130d06f6
http://europepmc.org/articles/PMC8497292

IL-6 Protein Expression is Increased in Fast Glycolytic Muscle Fibers Over Time in the SOD1G93A Mouse model

Autor: Laura Moreno Martínez, Alberto García-Redondo, Leticia Moreno-García, Gabriel García-Salamero, Claudia Tarlarini, Rosario Osta, Christian Lunetta, Silvana Penco, Ana C. Calvo, Pilar Zaragoza

The deregulation of the inflammatory cytokine interleukin (IL)-6 has been associated to a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The aim of this work was to analyze the variation of IL-6 levels in blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d610353cc59fba026091cf4629d4889a
https://doi.org/10.21203/rs.3.rs-785505/v1

Inflammasome in als skeletal muscle: Nlrp3 as a potential biomarker

Autor: Laura Moreno-Martínez, Rosario Osta, Christian Lunetta, Ana C. Calvo, Pilar Zaragoza, Claudia Tarlarini, Leticia Moreno-García, Miriam de la Torre, F. J. Miana-Mena

Publikováno v: International Journal of Molecular Sciences
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2523, p 2523 (2021)
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders, we hypothesized that levels of inflammasome components could help in diagnosis or prognosis of amyotrophic lateral sclerosis (ALS). Gene and protein expression was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90509c8664bc15d0786d62dd77fab7e
http://zaguan.unizar.es/record/102175

Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis

Autor: Ana Cristina Calvo, Inés Valledor-Martín, Laura Moreno-Martínez, Janne Markus Toivonen, Rosario Osta

Publikováno v: Genes. 13:865

The gut microbiota is able to modulate the development and homeostasis of the central nervous system (CNS) through the immune, circulatory, and neuronal systems. In turn, the CNS influences the gut microbiota through stress responses and at the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f827b6aa3e3dae27df1f4bc46f7338be
https://doi.org/10.3390/genes13050865