Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Laura Monereau"'
Autor:
Matthew D. Hill, Haiquan Fang, Derek Norris, George V. Delucca, Hong Huang, Mikkel DeBenedetto, Claude Quesnelle, William D. Schmitz, John S. Tokarski, Steven Sheriff, Chunhong Yan, Caroline Fanslau, Zuzana Haarhoff, Christine Huang, Melissa Kramer, Shilpa Madari, Krista Menard, Laura Monereau, John Morrison, Nirmala Raghavan, Eric E. Shields, Jean Simmermacher-Mayer, Michael Sinz, Ching Kim Tye, Richard Westhouse, Chunshan Xie, Haiying Zhang, Lisa Zhang, Tatyana Zvyaga, Francis Lee, Ashvinikumar V. Gavai, Andrew P. Degnan
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1165-1171
We describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35ad654e0ca7192653d0e07258cff5
https://doi.org/10.1021/acsmedchemlett.2c00219
https://doi.org/10.1021/acsmedchemlett.2c00219
Autor:
Emily C. Cherney, Liping Zhang, Julian Lo, Tram Huynh, Donna Wei, Vijay Ahuja, Claude Quesnelle, Gary L. Schieven, Alan Futran, Gregory A. Locke, Zeyu Lin, Laura Monereau, Charu Chaudhry, Jordan Blum, Sha Li, Mark Fereshteh, Bifang Li-Wang, Sanjeev Gangwar, Chin Pan, Colin Chong, Xiao Zhu, Shana L. Posy, John S. Sack, Ping Zhang, Max Ruzanov, Mary Harner, Fahad Akhtar, Gretchen M. Schroeder, Gregory Vite, Brian Fink
Publikováno v:
Journal of Medicinal Chemistry. 65:3518-3538
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::143c186739969ad25a3e8322819f4602
https://doi.org/10.1021/acs.jmedchem.1c01986
https://doi.org/10.1021/acs.jmedchem.1c01986
Autor:
Emily C, Cherney, Liping, Zhang, Julian, Lo, Tram, Huynh, Donna, Wei, Vijay, Ahuja, Claude, Quesnelle, Gary L, Schieven, Alan, Futran, Gregory A, Locke, Zeyu, Lin, Laura, Monereau, Charu, Chaudhry, Jordan, Blum, Sha, Li, Mark, Fereshteh, Bifang, Li-Wang, Sanjeev, Gangwar, Chin, Pan, Colin, Chong, Xiao, Zhu, Shana L, Posy, John S, Sack, Ping, Zhang, Max, Ruzanov, Mary, Harner, Fahad, Akhtar, Gretchen M, Schroeder, Gregory, Vite, Brian, Fink
Publikováno v:
Journal of medicinal chemistry. 65(4)
The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncology therapy. Ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60f75ca953101dc705deef1178ecacf2
https://pubmed.ncbi.nlm.nih.gov/35108011
https://pubmed.ncbi.nlm.nih.gov/35108011
Autor:
Chunhong Yan, Francis Y. Lee, Ashvinikumar V. Gavai, Melissa Kramer, Frank Marsilio, Eric Shields, Laura Monereau, Zuzana Haarhoff, Richard A. Westhouse, Lisa Zhang, Gerry Everlof, John S. Tokarski, Matthew D. Hill, Tatyana Zvyaga, Asoka Ranasinghe, Carolynn Fanslau, Ching Kim Tye, Steven Sheriff, Christine Huang, Andrew P. Degnan, Krista Menard, John Morrison, Haiquan Fang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 44:128108
We describe our efforts to identify structurally diverse leads in the triazole-containing N1-carboline series of bromodomain and extra-terminal inhibitors. Replacement of the N5 “cap” phenyl moiety with various heteroaryls, coupled with additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd1b9be7f6bf8d56a691226fab9f262
https://doi.org/10.1016/j.bmcl.2021.128108
https://doi.org/10.1016/j.bmcl.2021.128108