Výsledky vyhledávání - "Laura Miceli-Libby"

Cardiovascular and Hematopoietic Defects Associated With Notch1 Activation in Embryonic Tie2-Expressing Populations

Autor: Jeong Kyo Yoon, Laura Miceli-Libby, Anne Harrington, Deepak Venkatesh, Kyung-Sook Park, Lucy Liaw

Publikováno v: Circulation Research. 103:423-431

Notch signaling is critical for the development and maintenance of the cardiovasculature, with loss-of-function studies defining roles of Notch1 in the endothelial/hematopoietic lineages. No in vivo studies have addressed complementary gain-of-functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d43f79dccc1d415ee6cae93beddd36
https://doi.org/10.1161/circresaha.108.177808

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Widespread Delta-Like-1 Expression in Normal Adult Mouse Tissue and Injured Endothelium Is Reflected by Expression of the Dll1LacZ Locus

Autor: Anne Harrington, Lucy Liaw, Bochiwe Hara-Kaonga, Michael J. Johnson, Laura Miceli-Libby, Ah-Kau Ng

Publikováno v: Journal of Vascular Research. 45:1-9

Background: Our study characterizes Delta-like 1 (Dll1) in the adult mouse, particularly in normal versus injured vasculature, with the aid of the transgenic Dll1LacZ line. Methods: Normal mouse adult tissues or those from the Dll1LacZ reporter line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e4d82f90aab06a04a8b0df4aa4b195c
https://doi.org/10.1159/000109072

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Genetically Increasing Myoc Expression Supports a Necessary Pathologic Role of Abnormal Proteins in Glaucoma

Autor: Simon W. M. John, Richard S. Smith, Douglas B. Gould, Mario Torrado, Laura Miceli-Libby, Olga V. Savinova, Stanislav I. Tomarev

Publikováno v: Molecular and Cellular Biology. 24:9019-9025

Despite the importance of MYOC for glaucoma, the protein's normal function(s) and the pathogenic mechanism(s) of MYOC mutations are not clear. Elevated intraocular pressure (IOP) and glaucoma are sometimes induced by corticosteroids, and corticostero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace3c0a5ddcbbd85bc1836b2e948f9d
https://doi.org/10.1128/mcb.24.20.9019-9025.2004

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Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

Autor: Maria Cecilia Mancini, Lewis C. Cantley, Philip E. Thorpe, Carla Mouta-Bellum, Lucy Liaw, Igor Prudovsky, Tatiana Petrova, David A. Fruman, Naoyuki Miura, Calvin P.H. Vary, Laura Miceli-Libby, Aleksander Kirov, Kari Alitalo

Publikováno v: Developmental Dynamics, vol. 238, no. 10, pp. 2670-2679

The phosphoinositide 3-kinase (PI3K) family has multiple vascular functions, but the specific regulatory isoform supporting lymphangiogenesis remains unidentified. Here, we report that deletion of the Pik3r1 gene, encoding the regulatory subunits p85

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad66e8f19fd069ad79a9fe1b41e41827
https://europepmc.org/articles/PMC2826787/

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Widespread delta-like-1 expression in normal adult mouse tissue and injured endothelium is reflected by expression of the Dll1LacZ locus

Autor: Laura, Miceli-Libby, Michael J, Johnson, Anne, Harrington, Bochiwe, Hara-Kaonga, Ah-Kau, Ng, Lucy, Liaw

Publikováno v: Journal of vascular research. 45(1)

Our study characterizes Delta-like 1 (Dll1) in the adult mouse, particularly in normal versus injured vasculature, with the aid of the transgenic Dll1(LacZ) line.Normal mouse adult tissues or those from the Dll1(LacZ) reporter line were analyzed for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f55bc0e8fb4301aecb58275daf9f49fc
https://pubmed.ncbi.nlm.nih.gov/17898542

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