Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Laura McDonald"'
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Malignant pleural mesothelioma (MPM) is an aggressive and rare tumour with poor prognosis. Most patients are diagnosed with advanced disease and there is a paucity of data on the humanistic burden of MPM in terms of impact on heal
Externí odkaz:
https://doaj.org/article/8f55bf7734cc424cb44119848300d20b
Autor:
Marieke Pape, Pauline A. J. Vissers, Willemieke P. M. Dijksterhuis, David Bertwistle, Laura McDonald, Bianca Mostert, Sarah Derks, Irma M. Oving, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Treatment of advanced or metastatic esophageal adenocarcinoma (EAC) follows the guidelines for gastroesophageal junction adenocarcinoma (GEJC) and gastric adenocarcinoma (GAC), but patients with EAC are often excluded from clinical studie
Externí odkaz:
https://doaj.org/article/da8a32e3e4c643658b983aa7f4de6aaa
Autor:
Nuria Lara, Montserrat Roset, Fiona Blackhall, Nicolas Girard, Laura McDonald, Alain Livartowski, Ariadna Juarez García
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Objective Describe characteristics, treatment patterns and clinical outcomes of patients with small-cell lung cancer (SCLC).Design Retrospective chart review study defining several cohorts: (1) limited-stage disease (LD) SCLC initiating 1L therapy (1
Externí odkaz:
https://doaj.org/article/9bb28ed16b424cbfb7efd814eaac5811
Autor:
Marieke Pape, Pauline A. J. Vissers, David Bertwistle, Laura McDonald, Marije Slingerland, Nadia Haj Mohammad, Laurens V. Beerepoot, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Paul M. Jeene, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Real-world data on treatment and outcomes in patients with synchronous metastatic disease compared with patients with metachronous metastatic disease in esophagogastric cancer have not been published before. The aim of our study was to ex
Externí odkaz:
https://doaj.org/article/2c976c490a0d44018ae1ad2163774b56
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-5 (2019)
Abstract Understanding the patient perspective is fundamental to delivering patient-centred care. In most healthcare systems, however, patient-reported outcomes are not regularly collected or recorded as part of routine clinical care, despite evidenc
Externí odkaz:
https://doaj.org/article/4002e46813ad42d3b5c1a2a9d3182803
Autor:
Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibr
Externí odkaz:
https://doaj.org/article/95c1f45d24284070873d0d702ce64647
Publikováno v:
F1000Research, Vol 7 (2018)
Recent studies have used mainstream consumer devices (Fitbit) to assess sleep objectively and test the well documented association between sleep and body mass index (BMI). In order to further investigate the applicability of Fitbit data for biomedica
Externí odkaz:
https://doaj.org/article/517883a9fa074b4789bb9b02b7ddf3fd
Publikováno v:
F1000Research, Vol 7 (2018)
Data other than that from clinical trials are important for healthcare decision making. However, unlike the vocal calls seen for more open access to trial data, there are limited efforts being made to ensure that agencies that collect real-world data
Externí odkaz:
https://doaj.org/article/a1e639c86dac41dab46c486380ba7ef5
Autor:
Vanessa M. D’Costa, Virginie Braun, Marija Landekic, Rong Shi, Ariane Proteau, Laura McDonald, Miroslaw Cygler, Sergio Grinstein, John H. Brumell
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1508-1518 (2015)
Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood. Here, we show that the Salmonella enterica t
Externí odkaz:
https://doaj.org/article/17bde13531c845b49f53f66a85fa1101