Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura McCloskey"'
Autor:
Thomas Williams, Kevin Kalinka, Rui Sanches, Greg Blanchard-Emmerson, Samuel Watts, Lee Davies, Carol Knevelman, Laura McCloskey, Peter Jones, Kyriacos Mitrophanous, James Miskin, Duygu Dikicioglu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Process analytical technology (PAT) has demonstrated huge potential to enable the development of improved biopharmaceutical manufacturing processes by ensuring the reliable provision of quality products. However, the complexities associated
Externí odkaz:
https://doaj.org/article/5ba382014cbb4084ad4e23ec8b56f489
Autor:
Daniel C Farley, Laura McCloskey, Barbara A Thorne, Semih U Tareen, Christopher J Nicolai, David J Campbell, Richard Bannister, Hannah J Stewart, Laura JE Pearson, Bentley J Moyer, Scott H Robbins, Leah Zielinski, Tae Kim, Pippa A Radcliffe, Kyriacos A Mitrophanous, Wayne R Gombotz, James E Miskin, Brenna Kelley-Clarke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use in clinical trials. Immune Design previously described an HIV-1-based integration-deficient
Externí odkaz:
https://doaj.org/article/7f7c5943dd9b4748b580d44545f0e674
Autor:
Julie Loader, Michelle Kelleher, Kyriacos A. Mitrophanous, Vicky Kennedy, Laura McCloskey, Maria Parker, Naghmeh Fouladi, Scott Ellis, Katie Binley, J. Timothy Stout
Publikováno v:
Human Gene Therapy. 29:687-698
Due to both the avascularity of the cornea and the relatively immune-privileged status of the eye, corneal transplantation is one of the most successful clinical transplant procedures. However, in high-risk patients, which account for >20% of the 180
Autor:
Ian Blount, G. Scott Ralph, Kyriacos A. Mitrophanous, Stéphane Palfi, Laura McCloskey, Alan J. Kingsman, Owen Wells, Christelle J M Truran, Lucy Barnes, Liang Fong-Wong, Iain T. Strickland, Hannah J Stewart
Publikováno v:
Human gene therapy. Clinical development. 27(3)
Pharmacological dopamine replacement therapies provide the most well-established treatments for Parkinson's disease (PD). However, these long-term treatments can lead to motor complications and off-target effects. ProSavin(®), a lentiviral vector (L
Autor:
Linda Darling-Hammond, Laura McCloskey
Publikováno v:
Phi Delta Kappan. 90:263-272
Autor:
Binoy Appukuttan, Tim Stout, Kyriacos A. Mitrophanous, Khilan Shah, Maria Parker, Laura McCloskey, Scott Ellis, Trevor J. McFarland, Frank Larkin, Matt Hartzell, Vicky Kennedy, Simon Chandler
Publikováno v:
Molecular Therapy. 23
Corneal transplantation is one of the most successful transplant procedures because of the relatively immune-privileged status of the eye and the avascularity of the cornea. However, normal corneal immune privilege can be eroded by neovascularization
Publikováno v:
Human gene therapy methods. 24(2)
ProSavin(®) is a lentiviral vector (LV)-based gene therapy for Parkinson's disease. ProSavin(®) is currently in a Phase I/II clinical trial using material that was generated by transient transfection of adherent human embryonic kidney (HEK)293T cel
Autor:
Julie Loader, Michelle Kelleher, Katie Binley, Naghmeh Fouladi, Scott Ellis, Kyriacos A. Mitrophanous, Laura McCloskey
Publikováno v:
Molecular Therapy. 24:S15
Due to both the avascularity of the cornea and the relatively immune-privileged status of the eye corneal transplantation is one of the most successful clinical transplant procedures. However in high risk patients, which account for >20% of the 100,0
Autor:
Violet Franks, Donald K. Pumroy, Laura McCloskey, Richard R. Bootzin, Kenneth J. Tarnowski, Robin Malinosky-Rummell, David J. Hansen, Claire A. Fishman, Haworth Continuing Features Submission
Publikováno v:
Child & Family Behavior Therapy. 15:67-91
Autor:
Anne Vernez Moudon, M. Wolf, Thomas D. Koepsell, David M. Buchner, Laura McCloskey, Matthew Q. Patterson, Jess F. Kraus
Publikováno v:
JAMA. 288(17)
ContextMotor vehicles struck and killed 4739 pedestrians in the United States in the year 2000. Older pedestrians are at especially high risk.ObjectiveTo determine whether crosswalk markings at urban intersections influence the risk of injury to olde