Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed 'bifunctional' gRNA in mRNA A6

Autor: Joshua Meehan, Suzanne M McDermott, Alasdair Ivens, Zachary Goodall, Zihao Chen, Zihao Yu, Jia Woo, Tyler Rodshagen, Laura McCleskey, Rebecca Sechrist, Kenneth Stuart, Lanying Zeng, Silvi Rouskin, Nicholas J Savill, Achim Schnaufer, Xiuren Zhang, Jorge Cruz-Reyes

Publikováno v: Meehan, J, McDermott, S M, Ivens, A, Goodall, Z, Chen, Z, Yu, Z, Woo, J, Rodshagen, T, McCleskey, L, Seachrist, R, Stuart, K D, Zeng, L, Rouskin, S, Savill, N J, Schnaufer, A, Zhang, X & Cruz-Reyes, J 2023, ' Trypanosome RNA helicase KREH2 differentially controls noncanonical editing and putative repressive structure via a novel proposed “bifunctional” gRNA in mRNA A6 ', NAR Genomics and Bioinformatics . https://doi.org/10.1093/nar/gkad453

U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed by guide RNAs (gRNAs). This editing may developmentally control respiration in bloodstream forms (BSF) and insect procyclic forms (PCF). Holo-editosomes include the ac

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https://www.pure.ed.ac.uk/ws/files/353452655/gkad453.pdf