Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

Autor: Juliette Fremaux, Claire Venin, Laura Mauran, Robert H. Zimmer, Gilles Guichard, Sébastien R. Goudreau

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.

Externí odkaz: https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b

Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

Autor: Claire Venin, Robert H. Zimmer, Ben Jones, Laura Mauran, Stavroula Bitsi, Alejandra Tomas, Didier Rognan, Florian Koensgen, Gilles Guichard, Sébastien R. Goudreau, Maria Lucey, Juliette Fremaux

Publikováno v: Chemical Science
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/c9sc02079a⟩
Chemical Science, The Royal Society of Chemistry, 2019, 10 (42), pp.9872-9879. ⟨10.1039/C9SC02079A⟩

International audience; The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of alpha-amino acid residues with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa0810e201c5d94816890ca7af7126b
http://hdl.handle.net/20.500.12278/7639

Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation

Autor: Gilles Guichard, Caterina Lombardo, Cameron D. Mackereth, Frédéric Rosu, Olivier Lambert, Laura Mauran, Juliette Fremaux, Marion Decossas, Valérie Gabelica, Gavin W. Collie, Karolina Pulka-Ziach

Publikováno v: Nature Chemistry. 7:871-878

The design and construction of biomimetic self-assembling systems is a challenging yet potentially highly rewarding endeavour that contributes to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ea207acc1da0260cafe1f5f73139cf
https://doi.org/10.1038/nchem.2353

α-Peptide-Oligourea Chimeras: Stabilization of Short α-Helices by Non-Peptide Helical Foldamers

Autor: Gilles Guichard, Brice Kauffmann, Benoit Odaert, Laura Mauran, Juliette Fremaux, Karolina Pulka-Ziach

Publikováno v: Angewandte Chemie (International ed. in English). 54(34)

Short α-peptides with less than 10 residues generally display a low propensity to nucleate stable helical conformations. While various strategies to stabilize peptide helices have been previously reported, the ability of non-peptide helical foldamer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcc2452c12440ec4a2ecfc0d77573c8
https://pubmed.ncbi.nlm.nih.gov/26136402