Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Laura Marruecos"'
Autor:
Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Recent findings suggest that Hematopoietic Stem Cells (HSC) and progenitors arise simultaneously and independently of each other already in the embryonic aorta-gonad mesonephros region, but it is still unknown how their different features ar
Externí odkaz:
https://doaj.org/article/e2c4801c11ca4edbbdc98a6129f4d110
Autor:
Laura Marruecos, Joan Manils, Cristina Moreta, Diana Gómez, Ingrid Filgaira, Anna Serafin, Xavier Cañas, Lluís Espinosa, Concepció Soler
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Abstract Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p5
Externí odkaz:
https://doaj.org/article/36f5ec065d8846e28b72cd7234991a5f
Publikováno v:
Cells, Vol 11, Iss 14, p 2157 (2022)
Although DNA degradation might seem an unwanted event, it is essential in many cellular processes that are key to maintaining genomic stability and cell and organism homeostasis. The capacity to cut out nucleotides one at a time from the end of a DNA
Externí odkaz:
https://doaj.org/article/3e1222ca04c24e4ebceae8aedc016ddf
Autor:
Lluís Espinosa, Laura Marruecos
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1278 (2021)
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and func
Externí odkaz:
https://doaj.org/article/69827e45c37147b49e2a4528960ac68f
Publikováno v:
Biomedicines, Vol 5, Iss 2, p 26 (2017)
Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB me
Externí odkaz:
https://doaj.org/article/f2e9cc6bd29c4c1582ad6a654f375f9a
Autor:
Roshana Thambyrajah, Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas
SummaryRecent findings are challenging the classical hematopoietic model in which long-term hematopoietic stem cells (LT-HSC) are the base of the hematopoietic system. Clonal dynamics analysis of the hematopoietic system indicate that LT-HSC are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9775779e3db756c4a2028b8178e2d4dc
https://doi.org/10.1101/2022.11.17.516971
https://doi.org/10.1101/2022.11.17.516971
Autor:
Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Angelique di Domenico, Yvonne Richaud, Jose Luis Mosquera, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J. Edel, Manel Juan Otero, Isidre Ferrer, Angel Raya, Antonella Consiglio
Parkinson’s disease (PD) is associated with premature death of dopamine-producing neurons in the brain. Previous studies have shown that astrocytes of PD patients may contribute to neuronal degeneration by mechanisms involving both direct cell-to-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2bb968ae16b7e22844716570ce0bf65
https://doi.org/10.1101/2022.08.23.504918
https://doi.org/10.1101/2022.08.23.504918
Autor:
Lluis Espinosa, Martin Floor, Anna Vert, Irene Pecharroman, Jordi Villà-Freixa, Yolanda Guillén, Gourisankar Ghosh, Laura Batlle, Joan Bertran, Daniel Álvarez-Villanueva, Luís G. Palma, Sara Arce-Gallego, Maria Carmen Mulero, Anna Bigas, Laura Marruecos
Publikováno v:
EMBO Rep
IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated and SUMOylated IκBα (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53e839b428b42295278b7a79d00334a
https://doi.org/10.15252/embr.202152649
https://doi.org/10.15252/embr.202152649
Autor:
Lluis Espinosa, Joan Bertran, Gourisankar Ghosh, Yolanda Guillén, Martin Floor, Anna Vert, Álvarez-Villanueva D, Anna Bigas, Batlle L, Arce S, Villà-Freixa J, Maria Carmen Mulero, Laura Marruecos
IκBs exert a principal function as cytoplasmic inhibitors of the NF-kB transcription factors. Additional functions for IκB homologues have been described including association to chromatin and transcriptional regulatioin. Phosphorylated and SUMOyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249b19736f04b11217350e290e198f5d
https://doi.org/10.1101/2021.02.15.431217
https://doi.org/10.1101/2021.02.15.431217
Autor:
Xavier Cañas, Diana Gómez, Laura Marruecos, Lluis Espinosa, Concepció Soler, Joan Manils, Anna Serafín, Cristina Moreta, Ingrid Filgaira
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease
Universidad de Barcelona
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death & Disease
Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we found that single p53 allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973ea422b13a226bd9f9b4ec3cdf7dc7
http://hdl.handle.net/2445/176681
http://hdl.handle.net/2445/176681