Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laura Marroqui"'
Autor:
Reinaldo S. Dos Santos, Daniel Guzman-Llorens, Atenea A. Perez-Serna, Angel Nadal, Laura Marroqui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionType 1 diabetes is characterized by pancreatic islet inflammation and autoimmune-driven pancreatic β-cell destruction. Interferon-α (IFNα) is a key player in early human type 1 diabetes pathogenesis. IFNα activates the tyrosine kinase
Externí odkaz:
https://doaj.org/article/a22780b71f194e82b50c368461c624a8
Autor:
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, José-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Publikováno v:
Environment International, Vol 164, Iss , Pp 107250- (2022)
17β-estradiol protects pancreatic β-cells from apoptosis via the estrogen receptors ERα, ERβ and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA), which exerts multiple effects in this cell type via the same estrogen receptors, increas
Externí odkaz:
https://doaj.org/article/3807ab81bc004a82a69801abd5f3f94e
Autor:
Eva Tudurí, Laura Marroqui, Reinaldo S. Dos Santos, Iván Quesada, Esther Fuentes, Paloma Alonso-Magdalena
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Bisphenol-A (BPA) is one of the most widespread endocrine disrupting chemicals (EDCs). It is used as the base compound in the production of polycarbonate and other plastics present in many consumer products. It is also used as a building block in epo
Externí odkaz:
https://doaj.org/article/703136035e304d459bbe5b56af13c98a
Autor:
Laura Marroqui, Matilde Masini, Beatriz Merino, Fabio A. Grieco, Isabelle Millard, Christine Dubois, Ivan Quesada, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Publikováno v:
EBioMedicine, Vol 2, Iss 5, Pp 378-385 (2015)
Pancreatic α cells are exposed to metabolic stress during the evolution of type 2 diabetes (T2D), but it remains unclear whether this affects their survival. We used electron microscopy to search for markers of apoptosis and endoplasmic reticulum (E
Externí odkaz:
https://doaj.org/article/35a1d42aada04fcb96ffbeb503cb4bd3
Autor:
Laura Marroqui, Miguel Lopes, Reinaldo S dos Santos, Fabio A Grieco, Merja Roivainen, Sarah J Richardson, Noel G Morgan, Anne Op de beeck, Decio L Eizirik
Publikováno v:
eLife, Vol 4 (2015)
Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis while neighboring α cells are preserved. Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimmunity in T1D. Cellular permissive
Externí odkaz:
https://doaj.org/article/6614f4cf216b4fbd8648d890b4621aae
Autor:
Atenea A. Perez-Serna, Reinaldo S. Dos Santos, Cristina Ripoll, Angel Nadal, Decio L. Eizirik, Laura Marroqui
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5657
Diabetes is a chronic disease that affects glucose metabolism, either by autoimmune-driven β-cell loss or by the progressive loss of β-cell function, due to continued metabolic stresses. Although both α- and β-cells are exposed to the same stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8d386666790c9af20837b9e1697fa3
Autor:
Reinaldo S. Dos Santos, Laura Marroqui Esclapez, Daniel Guzmán Llorens, Atenea Alexandra Perez-Serna, Angel Nadal
Aims/hypothesisType 1 diabetes is characterised by pancreatic islet inflammation and autoimmune-driven pancreatic beta cell destruction. Type I interferons, such as IFNα, are key players in early human type 1 diabetes pathogenesis, as the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0d4a471a496afb2fd321d3d04c90f8
https://doi.org/10.1101/2022.12.27.522037
https://doi.org/10.1101/2022.12.27.522037
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 231
Metabolism-disrupting chemicals (MDCs) are endocrine disruptors with obesogenic and/or diabetogenic action. There is mounting evidence linking exposure to MDCs to increased susceptibility to diabetes. Despite the important role of glucagon in glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d5ff6976d439e76fc56690c517ffa4
https://pubmed.ncbi.nlm.nih.gov/36613676
https://pubmed.ncbi.nlm.nih.gov/36613676
Autor:
Reinaldo Sousa Dos Santos, Regla María Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and dispersed mouse islet cells to assess the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb2f3ce6ddf40c5b03430b4f1020f76
https://doi.org/10.1101/2022.03.22.485271
https://doi.org/10.1101/2022.03.22.485271
Autor:
Enriqueta Garcia-Gutierrez, A. Kate O’Mahony, Reinaldo Sousa Dos Santos, Laura Marroquí, Paul D. Cotter
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), type 2 diabetes (T2D) and gestational diabetes mellitus (GDM). T1D and T2D are chronic disea
Externí odkaz:
https://doaj.org/article/db35676933af4730b110ce696e202552