Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laura Marler"'
Autor:
Brian T. Murphy, John M. Pezzuto, Sang-Jip Nam, Bernard D. Santarsiero, Laura Marler, Skylar Carlson
Publikováno v:
Marine Drugs, Vol 11, Iss 4, Pp 1152-1161 (2013)
Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing molecules, we identified a mar
Externí odkaz:
https://doaj.org/article/172e89e421e343ca80741f5c61993b3e
Publikováno v:
Nucleic Acids Research
In translation initiation, a 43S preinitiation complex (PIC) containing eIF1 and a ternary complex (TC) of GTP-bound eIF2 and Met-RNAi scans the mRNA for the start codon. AUG recognition triggers eIF1 release and rearrangement from an open PIC confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376a2d515a8100fcdb9cad4014f0d0b
http://europepmc.org/articles/PMC6411837
http://europepmc.org/articles/PMC6411837
Autor:
Venki Ramakrishnan, Tanweer Hussain, Laura Marler, Anil Thakur, Colin Echeverría Aitken, Alan G. Hinnebusch, Jon R. Lorsch, José Luis Llácer
Publikováno v:
Molecular Cell
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Summary Translation initiation in eukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal subunit, eIF1, eIF1A, eIF3, ternary complex (eIF2-GTP-Met-tRNAi), and eIF5. The PIC, in an open conformation, attach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9102f8b86ee40f999b6b37446b9b0287
https://doi.org/10.1016/j.molcel.2015.06.033
https://doi.org/10.1016/j.molcel.2015.06.033
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)
Autor:
John M. Pezzuto, Eun-Jung Park, Abdelrahman S. Mayhoub, Mark Cushman, Tamara P. Kondratyuk, Laura Marler
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:7030-7039
NAD(P)H:quinone reductase 1 (QR1) belongs to a class of enzymes called cytoprotective enzymes. It exhibits its cancer protective activity mainly by inhibiting the formation of intracellular semiquinone radicals, and by generating α-tocopherolhydroqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5642b13e1fff3efa3151e7741a724d
https://doi.org/10.1016/j.bmc.2012.10.006
https://doi.org/10.1016/j.bmc.2012.10.006
Autor:
Safia Ahmed, Leng Chee Chang, Nighat Fatima, Hira Mehboob Mirza, Muniba Jadoon, Muneer Ahmed Qazi, John M. Pezzuto, Eun-Jung Park, Laura Marler, Ibrar Khan, Naima Atiq, Tamara P. Kondratyuk
Publikováno v:
Pharmaceutical biology. 54(11)
Endophytic fungi, being a prolific source of bioactive secondary metabolites, are of great interest for natural product discovery.Isolation and partial characterization of endophytic fungi inhabiting the leaves and woody parts of Taxus fuana Nan LiR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8913385dfa313d880761d3a4202abb6d
https://pubmed.ncbi.nlm.nih.gov/27159021
https://pubmed.ncbi.nlm.nih.gov/27159021
Autor:
Bushra Mirza, Ihsan-ul-Haq, John M. Pezzuto, Brittany E Burns, Laura Marler, Eun-Jung Park, Tamara P. Kondratyuk
Publikováno v:
Pharmaceutical Biology. 51:316-328
Natural products are a very productive source of leads for the development of medicines. Six Pakistani plants were chosen for study based on ethnobotanical data.Exploration of important medicinal plants of Pakistan for cancer treatment.The crude extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e548713f4397f6d0815719d7b4ee9fb
https://doi.org/10.3109/13880209.2012.728612
https://doi.org/10.3109/13880209.2012.728612
Autor:
Bin Sun, Andrew D. Mesecar, John M. Pezzuto, Juma Hoshino, Laura Marler, Katie Jermihov, Mark Cushman
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:5352-5366
A series of new resveratrol analogues were designed and synthesized and their inhibitory activities against aromatase were evaluated. The crystal structure of human aromatase (PDB 3eqm) was used to rationalize the mechanism of action of the aromatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93481d95c7b77f72f481ea86b7d123d
https://doi.org/10.1016/j.bmc.2010.05.042
https://doi.org/10.1016/j.bmc.2010.05.042
Autor:
Ying Liu, Harry H. S. Fong, Hongjie Zhang, Ye-Gao Chen, Jian Hong Yang, Andrew D. Mesecar, Yongsoo Choi, Rui Yu, John M. Pezzuto, Scott D. Pegan, Laura Marler, Megan Sturdy, Richard B. van Breemen, Li Qin Wang, Xi Qiu, Hongmei Cao, Tamara P. Kondratyuk
Publikováno v:
Phytochemistry. 71:641-647
Three new kaempferol glycosides, named palmatosides A (1), B (2) and C (3), together with three known kaempferol glycosides, multiflorins A (4) and B (5), and afzelin (6), were isolated from the roots of the fern Neocheiropteris palmatopedata. Palmat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff6f84171aeb8cd2277a22e42f85f68
https://doi.org/10.1016/j.phytochem.2010.01.002
https://doi.org/10.1016/j.phytochem.2010.01.002
Autor:
Shao-Nong Chen, Yan Luo, Richard B. van Breemen, Laura Marler, Richard C. Moon, Muriel Cuendet, Carol P. Oteham, John M. Pezzuto, Jian Guo
Publikováno v:
Cancer Prevention Research. 3:221-232
Isoliquiritigenin (2′,4′,4-trihydroxychalcone; ILG), a chalcone found in licorice root and many other plants, has shown potential chemopreventive activity through induction of phase II enzymes such as quinone reductase-1 in murine hepatoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b7497022cee7b6bd022d30358d9d14
https://doi.org/10.1158/1940-6207.capr-09-0049
https://doi.org/10.1158/1940-6207.capr-09-0049
Autor:
Muhammad Asad Ghufran, Aniqa Batool, Jacquelyn M. Guilford, John M. Pezzuto, Leng Chee Chang, Tamara P. Kondratyuk, Rizwana Aleem Qureshi, Laura Marler
Publikováno v:
Pharmaceutical Biology. 47:533-538
The western Himalayas in the northern areas of Pakistan have significant potential for ethnomedicinal research. In the current study, indigenous informants were interviewed using open-ended questionnaires and a free-listing of knowledge related to na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c14ea1f7da1efb0c30f1d0f5ffdcba
https://doi.org/10.1080/13880200902873847
https://doi.org/10.1080/13880200902873847