Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laura Maringele"'
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002417 (2011)
Cells accumulate single-stranded DNA (ssDNA) when telomere capping, DNA replication, or DNA repair is impeded. This accumulation leads to cell cycle arrest through activating the DNA-damage checkpoints involved in cancer protection. Hence, ssDNA accu
Externí odkaz:
https://doaj.org/article/c9333588a5f741f699b895ee1ba12c9c
Autor:
Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless, Min Yu, Kaye Chapman, A Peter Banks, Hien-Ping Ngo, Laura Maringele, Morgan Taschuk, Alexander Young, Adam Ciesiolka, Allyson Lurena Lister, Anil Wipat, Darren James Wilkinson, David Lydall
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001362 (2011)
To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1) or containing a null mutation in the
Externí odkaz:
https://doaj.org/article/9b28f9f63e7b434e899130efd26f9f54
Publikováno v:
Molecular and Cellular Biology. 43:185-199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96a2e8c0d7173cb2a5bf0eb4317d13f2
https://doi.org/10.1080/10985549.2023.2193768
https://doi.org/10.1080/10985549.2023.2193768
Autor:
Iglika G, Ivanova, Laura, Maringele
Publikováno v:
Nucleic Acids Research
Damaged DNA can be repaired by removal and re-synthesis of up to 30 nucleotides during base or nucleotide excision repair. An important question is what happens when many more nucleotides are removed, resulting in long single-stranded DNA (ssDNA) les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cd1d6cec2f7c5ee75fbee6bd6965357
https://pubmed.ncbi.nlm.nih.gov/26883631
https://pubmed.ncbi.nlm.nih.gov/26883631
Publikováno v:
Molecular and Cellular Biology. 31:1637-1645
Replicative senescence is a permanent cell cycle arrest in response to extensive telomere shortening. To understand the mechanisms behind a permanent arrest, we screened for factors affecting replicative senescence in budding yeast lacking telomere e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fab80a2e332637164553d76c5f3f68
https://doi.org/10.1128/mcb.00144-10
https://doi.org/10.1128/mcb.00144-10
Publikováno v:
Genetics
Inverted chromosome duplications or palindromes are linked with genetic disorders and malignant transformation. They are considered by-products of DNA double-strand break (DSB) repair: the homologous recombination (HR) and the nonhomologous end joini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4258614826164fd6d9f28113373d4768
https://pubmed.ncbi.nlm.nih.gov/27334270
https://pubmed.ncbi.nlm.nih.gov/27334270
Autor:
Laura Maringele, David Lydall
Publikováno v:
Cell Cycle. 4:747-751
It is generally accepted that cells with extensive, un-repaired DNA damage can escape cell cycle arrest only by disabling checkpoint pathways and they usually perish, after several divisions, presumably due to catastrophic events on their chromosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2ca159d249e31ff2241f6e886414f6
https://doi.org/10.4161/cc.4.6.1741
https://doi.org/10.4161/cc.4.6.1741
Autor:
Laura Maringele, David Lydall
Publikováno v:
Genetics. 166:1641-1649
Telomerase-defective budding yeast cells escape senescence by using homologous recombination to amplify telomeric or subtelomeric structures. Similarly, human cells that enter senescence can use homologous recombination for telomere maintenance, when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5052be8fbd796911fec6c8b0d8b915c
https://doi.org/10.1093/genetics/166.4.1641
https://doi.org/10.1093/genetics/166.4.1641
Autor:
Alexander I. Young, Min Yu, Morgan Taschuk, Darren J. Wilkinson, Conor Lawless, Hien-Ping Ngo, David Lydall, Laura Maringele, Adam Ciesiolka, Eva-Maria Holstein, Stephen G. Addinall, Allyson L. Lister, A. Peter Banks, Anil Wipat, Kaye Chapman
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 7, Iss 4, p e1001362 (2011)
PLoS Genetics, Vol 7, Iss 4, p e1001362 (2011)
To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1) or containing a null mutation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa87b054549537091028e953c5529aac
https://pubmed.ncbi.nlm.nih.gov/21490951
https://pubmed.ncbi.nlm.nih.gov/21490951
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52
Autor:
Catherine LeBel, David C.F. Sealey, David Lydall, Emanuel Rosonina, Fiona E. Pryde, Laura Maringele, Lea Harrington
Publikováno v:
Genetics. 182(3)
Telomeres are essential features of linear genomes that are crucial for chromosome stability. Telomeric DNA is usually replenished by telomerase. Deletion of genes encoding telomerase components leads to telomere attrition with each cycle of DNA repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451a3672d9b805bebd32315e51b3c44b
https://pubmed.ncbi.nlm.nih.gov/19380905
https://pubmed.ncbi.nlm.nih.gov/19380905