A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Autor: Rosemary Rochford, Kristina S. Wickham, Xavier C. Ding, David A. Fidock, Margaret A. Phillips, Thomas Rueckle, Sandra March, Brice Campo, Anna Marie Zeeman, Andrea Ruecker, Iñigo Angulo-Barturen, Xiaoyi Deng, Sergio Wittlin, Michael J. Delves, Farah El Mazouni, Susan A. Charman, Diana R. Tomchick, Laura Maria Sanz Alonso, Jacqueline W. Njoroge, Robert E. Sinden, Jeremy N. Burrows, Ian Bathhurst, Anthony Dayan, Lalitha V. Iyer, Trevor Laird, Koen J. Dechering, Caroline L. Ng, Sandra Duffy, Janet Gahagen, Jon C. Mirsalis, M. John Rogers, Kennan C. Marsh, Yanbin Lao, Pradipsinh K. Rathod, James B. Louttit, Santiago Ferrer Bazaga, Julie Lotharius, Yi Cui, Sreekanth Kokkonda, Francisco Javier Gamo Benito, Arun Sridhar, John H. White, María Santos Martínez, Maria J. Lafuente-Monasterio, María Belén Jiménez-Díaz, John N. Haselden, Sangeeta N. Bhatia, Didier Leroy, Robert W. Sauerwein, Clemens H. M. Kocken, Vicky M. Avery, Ed Riccio, Karen L. White

Publikováno v: Science Translational Medicine, 7, 296, pp. 296ra111
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PMC
Science Translational Medicine, 7, 296ra111

Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating malaria requires development of new, easy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcc77c46ef071db2bb33bf845ab1ab
https://doi.org/10.1126/scitranslmed.aaa6645