Výsledky vyhledávání - "Laura M. Vargas-Roig"

Circulating heat shock protein 27 (HSPB1) levels in prediction of pre‐eclampsia: A pilot study

Autor: Eduardo Rodriguez-Echandia, Laura M. Vargas-Roig, Analia Lourdes Redondo, Gisel V. Gauna, Alfonsa C. Anzalone, Carina Grajeda, Mayra L. Sottile, Marina Ines Flamini, Silvina B. Nadin, Raquel L. Martin, Laura C Gomez

Publikováno v: International Journal of Gynecology & Obstetrics. 158:93-100

OBJECTIVE To determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early prediction of the occurrence of pre-eclampsia in asymptomatic women. METHODS We have measured by ELISA the levels of HSPB1, HSPC1, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44400dba72e34640fae32badb7f8486
https://doi.org/10.1002/ijgo.13982

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Double heterozygous pathogenic variants in the BRCA1 and BRCA2 genes in a patient with bilateral metachronous breast cancer

Autor: Mayra L. Sottile, Laura M. Vargas-Roig, Silvina P. Denita-Juárez, Alejandra Mampel, Ana Lía Vargas

Publikováno v: Cancer genetics.

Double heterozygosity pathogenic variants in BRCA1 and BRCA2 genes are a very rare finding, particularly in non-Ashkenazi individuals. We described the first case of double heterozygosity variants in a non-Ashkenazi Argentinean woman with metachronou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc1c524d2f8dc3dcaefabcaa467b2f0
https://pubmed.ncbi.nlm.nih.gov/34801929

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Synergistic antitumor activity by combining trastuzumab with retinoic acid in HER2 positive human breast cancer cells

Autor: Analia Lourdes Redondo, Angel Matias Sanchez, Fiorella Vanderhoeven, Laura M. Vargas-Roig, Ana Laura Martinez, Marina Ines Flamini

Publikováno v: Oncotarget

Breast cancer can be classified into molecular subtypes. Tumors overexpressing HER2 protein are more aggressive and metastatic; hence, patients have a poor prognosis. Anti-HER2 strategies, such as the monoclonal antibody Trastuzumab (Tz), have theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62311e8ede2df7ddfd607f119e06caf
https://doi.org/10.18632/oncotarget.25480

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TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer

Autor: Laura C Gomez, Francisco E. Gago, Javier I. J. Orozco, Analia Lourdes Redondo, Felipe Carlos Martín Zoppino, Laura M. Vargas-Roig, Mayra L Sottile, Olga Tello, Martin E. Guerrero-Gimenez, Silvina B. Nadin, María Roqué, Diego M. Marzese

Publikováno v: Journal of Clinical Pathology. 71:52-58

Aim: Accumulated evidence suggests that aberrant methylation of the TP73 gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However, little is known regarding the transcriptional and functional regulation of the TP7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d552323a32317b9a6cefc118b202031
https://doi.org/10.1136/jclinpath-2017-204499

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Luteal Expression of Thyroid Hormone Receptors During Gestation and Postpartum in the Rat

Autor: F. Darío Cuello-Carrión, María Belén Hapon, Susana R. Valdez, Paola B. Navas, Graciela A. Jahn, Analía L. Redondo, Laura M. Vargas Roig

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

BACKGROUND: Progesterone (P4) is the main steroid secreted by the corpora lutea (CL) and is required for successful implantation and maintenance of pregnancy. Although adequate circulating levels of thyroid hormone (TH) are needed to support formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103d34a4b07ec32109f3ffd0c363bd42
https://doi.org/10.1089/thy.2013.0332

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Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats

Autor: Graciela A. Jahn, Susana Ruth Valdez, Juan Pablo Mackern-Oberti, Laura M. Vargas-Roig

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Mammary stroma is composed of various cell types, including migratory leukocytes. Although mammary antibody-secreting cells have been extensively studied, reports focusing on mammary T cells are scarce. It is thought that the recruitment mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1042337487f53f37bf16c33c6e2331d
https://doi.org/10.1530/rep-12-0387

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Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin

Autor: Marina Inés Flamini, Angel Matías Sanchez, Jorge Eduardo Shortrede, Laura M. Vargas-Roig

Breast cancer is the most common malignancy in women, with metastases being the cause of death in 98%. In previous works we have demonstrated that retinoic acid (RA), the main retinoic acid receptor (RAR) ligand, is involved in the metastatic process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58b66e05bc7c684e429d0aa81f1d28a
https://www.sciencedirect.com/science/article/pii/S0303720716301344

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Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines

Autor: Laura M. Vargas-Roig, Silvina B. Nadin, Antonella D Losinno, F. Darío Cuello-Carrión, Mariel A. Fanelli, Maria Magdalena Montt-Guevara, Mayra L Sottile

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Purpose: Hyperthermia is used in combination with conventional anticancer agents to potentiate their cytotoxicity. One of its key events is the synthesis of heat shock proteins (HSPs), which are able to associate with components from DNA repair mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b608a2ca6d20048f506a65695619c111
https://www.tandfonline.com/doi/full/10.3109/02656736.2015.1026848

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DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: A pilot study on the implications in the clinical response to chemotherapy

Autor: Silvina B. Nadin, Daniel R. Ciocca, Laura M. Vargas-Roig, Gisela Drago, Jorge Ibarra

Publikováno v: Cancer Letters. 239:84-97

Drug resistance is considered the main impediment to successful cancer chemotherapy. The quest for a method useful to predict individual responses to chemotherapy prior to treatment is highly desired. This study was designed to determine the individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fac1184475e530dee4829df0acce916
https://doi.org/10.1016/j.canlet.2005.07.025

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DNA damage induced by paclitaxel and DNA repair capability of peripheral blood lymphocytes as evaluated by the alkaline comet assay

Autor: Daniel R. Ciocca, Marı́a Teresita Branham, Laura M. Vargas-Roig, Silvina B. Nadin

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 560:11-17

This study was designed to assess whether the chemotherapeutic drug paclitaxel can induce DNA damage in peripheral blood lymphocytes of human healthy donors, and to evaluate if such damage could be repaired. Venous blood was collected by routine veni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04a18d5b7fb137f946e93c2083914d0
https://doi.org/10.1016/j.mrgentox.2004.01.013

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