Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura M. Urbanski"'
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Ashton C. Berger, John P. Busanovich, Naomi Curimjee, Hope Wei, Sirano Dhe-Paganon, Jack A. Kosmicki, Meredith S. Brown, Andrew D. Cherniack, Rameen Beroukhim, Galen F. Gao, Brenton R. Paolella, Caitlin A. Nichols, Laura M. Urbanski, William J. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69932bff7bf9743b48a41cd448c169c1
https://doi.org/10.1038/s41467-020-16399-y
https://doi.org/10.1038/s41467-020-16399-y
Autor:
Rameen Beroukhim, Aviad Tsherniak, John A. Alberta, Barbara A. Weir, Glenn S. Cowley, Esther A. Obeng, Belinda Wong, Charles D. Stiles, William C. Hahn, Robin Reed, Yong Yu, Benjamin L. Ebert, Meredith Brown, Rebecca Lamothe, Laura M. Urbanski, William J. Gibson, David E. Root, Caitlin A. Nichols, Pratiti Bandopadhayay, Francisca Vazquez, Guo Wei, Peter S. Choi, Travis I. Zack, Brenton R. Paolella
Many pediatric cancers exhibit widespread somatic copy number alterations. We integrated a genome-scale shRNA viability screen and copy number profiles from 179 cancer cell lines to perform an unbiased analysis of copy-number associated gene-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29da7c1cd9c8eed5c1a43243a02dc9
https://europepmc.org/articles/PMC5474993/
https://europepmc.org/articles/PMC5474993/
Autor:
Benjamin L. Ebert, Belinda Wang, Barbara A. Weir, Pankaj K. Agarwalla, Aviad Tsherniak, Meredith Brown, Charles D. Stiles, Rameen Beroukhim, William J. Gibson, Sara J. Buhrlage, John A. Alberta, William C. Hahn, Guo Wei, Peter S. Choi, Esther A. Obeng, Pratiti Bandopadhayay, Laura M. Urbanski, Caitlin A. Nichols, Glenn S. Cowley, Robin Reed, Brenton R. Paolella, Rebecca Lamothe, Travis I. Zack, Francisca Vazquez, Yong Yu, Dirk Heckl, David E. Root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac611ac7a7ecb0fa1740892bfad3caf0
https://doi.org/10.7554/elife.23268.025
https://doi.org/10.7554/elife.23268.025
Autor:
Guo Wei, Benjamin L. Ebert, Yong Yu, Travis I. Zack, Sara J. Buhrlage, David E. Root, Pankaj K. Agarwalla, Meredith Brown, Dirk Heckl, Laura M. Urbanski, Peter S. Choi, Barbara A. Weir, Aviad Tsherniak, Esther A. Obeng, Glenn S. Cowley, Robin Reed, Brenton R. Paolella, Pratiti Bandopadhayay, Rameen Beroukhim, John A. Alberta, Rebecca Lamothe, Francisca Vazquez, William J. Gibson, Caitlin A. Nichols, Belinda Wang, Charles D. Stiles, William C. Hahn
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aa0272ca1a43ca064fe0c41c1a8420
https://elifesciences.org/articles/23268
https://elifesciences.org/articles/23268
Autor:
Stéphanie Puget, Mariarita Santi, Daniel C. Bowers, Cynthia Hawkins, Rosemary E. Henn, Laura M. Urbanski, Jeremiah Wala, Mélanie Pagès, Azra H. Ligon, Anna Maria Buccoliero, Peleg M. Horowitz, Phillip B. Storm, Mirko Scagnet, Liliana Goumnerova, Matthew D. Ducar, Kristine Pelton, Pascale Varlet, Uri Tabori, Sabine Mueller, Pratiti Bandopadhayay, Yun Jee Kang, Rameen Beroukhim, Joanna J. Phillips, Adam C. Resnick, Payal Jain, Brenton R. Paolella, László Bognár, Mark W. Kieran, David S. Knoff, Yuankun Zhu, Rhamy Zeid, Shakti Ramkissoon, Charles G. Eberhart, Hayley Malkin, Adam Tracy, Katie Boucher, Amanda Silva, Lori A. Ramkissoon, Adrianne Gladden-Young, Keith L. Ligon, Nada Jabado, Jacques Grill, Daphne A. Haas-Kogan, Sandro Santagata, James E. Bradner, Charles D. Stiles, Alexander J. Federation, Harry J. Han, Almos Klekner, Angela J. Waanders, Sara Seepo, Ryan O’Rourke, Paul Van Hummelen, Namrata Choudhari, D. Ashley Hill, Fausto J. Rodriguez, Caterina Giannini, William J. Gibson, Alon Goren, Peter C. Burger, Guillaume Bergthold, Steven E. Schumacher
Publikováno v:
Nature genetics
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15b7c487f4af339f179cee71e0554d0
http://hdl.handle.net/11585/721376
http://hdl.handle.net/11585/721376
Autor:
Meredith Brown, Brenton R. Paolella, Laura M. Urbanski, Ashton C. Berger, Caitlin A. Nichols, Jack A. Kosmicki, John P. Busanovich, William J. Gibson, Galen F. Gao, Andrew D. Cherniack, Rameen Beroukhim
Publikováno v:
Cancer Research. 78:3003-3003
Despite progress in precision cancer drug discovery, few highly selective therapies exist in the clinic, creating the need for additional therapeutic targets. We have shown that copy number alterations (CNAs) in essential genes represent novel non-dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f6b2bf8cc168822555e55e0285d300
https://doi.org/10.1158/1538-7445.am2018-3003
https://doi.org/10.1158/1538-7445.am2018-3003
Autor:
Wenya Linda Bi, Vishwajith Sridharan, Ian F. Dunn, David A. Reardon, Shakti Ramkissoon, Michael B. Miller, Laura M. Urbanski, Katrina Thistle
Publikováno v:
World neurosurgery. 84(4)
Background Multicentric low-grade gliomas are rare entities that occur in disparate regions of the brain. They can present with distinct pathologic and imaging findings and may harbor a worse prognosis. We present a case of multicentric low-grade gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bfc861ba9fc843de9dcb71e32129da
https://pubmed.ncbi.nlm.nih.gov/26004698
https://pubmed.ncbi.nlm.nih.gov/26004698
Publikováno v:
The FASEB Journal. 28
Protein splicing is the post translational modification by which an internal peptide, or intein, separates itself from the surrounding residues, known as exteins. In the third step of the mechanism...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c44ace84c5a4b552063528eb61e99e7
https://doi.org/10.1096/fasebj.28.1_supplement.768.4
https://doi.org/10.1096/fasebj.28.1_supplement.768.4