Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura M. Sack"'
Autor:
Laura M Sack, Lauren Mertens, Elissa Murphy, Laura Hutchinson, Anne B S Giersch, Heather Mason-Suares
Publikováno v:
Clinical Chemistry. 69:583-594
Background Biallelic deletions at 15q15.3, including STRC and CATSPER2, cause autosomal recessive deafness-infertility syndrome (DIS), while biallelic deletions of STRC alone cause nonsyndromic hearing loss. These deletions are among the leading gene
Autor:
Amy K. Johnson, Duanjun Tan, Lora J. H. Bean, Arunkanth Ankala, Hua Gao, Hong Cui, Laura M. Sack, Amy Lai, Gabriele Richard, Lisa M. Vincent, Tracy Brandt, Jeanne Meck, Hui Mei, Dolores Arjona, Daniela del Gaudio, Caitlin Reavey
Publikováno v:
Genetics in Medicine. 22:336-344
Purpose The ability of a single technology, next-generation sequencing, to provide both sequence and copy number variant (CNV) results has driven the merger of clinical cytogenetics and molecular genetics. Consequently, the distinction between the de
Autor:
Roderick Brathwaite, Yanhui Hu, Xiaochun Ni, Martha L. Bulyk, Donghui Yang-Zhou, Laura M. Sack, Jonathan Zirin, Stephen J. Elledge, Norbert Perrimon
Publikováno v:
Proceedings of the National Academy of Sciences. 116:14614-14619
Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of Drosophila genes that are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes required for cellular
Publikováno v:
Cancer Genetics. :S12-S13
Autor:
Gabriele Richard, Hui Mei, Caitlin Reavey, Laura M. Sack, Amy K. Johnson, Duanjun Tan, Lisa M. Vincent, Amy Lai, Hua Gao, Daniela del Gaudio, Jeanne Meck, Tracy Brandt, Dolores Arjona, Lora J. H. Bean, Arunkanth Ankala, Hong Cui
Publikováno v:
Genetics in Medicine. 22:670-671
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2781-2790 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2781-2790 (2016)
Genetic screens are invaluable tools for dissection of biological phenomena. Optimization of such screens to enhance discovery of candidate genes and minimize false positives is thus a critical aim. Here, we report several sources of error common to
Publikováno v:
Genes & Development. 30:293-306
Senescence stimuli activate multiple tumor suppressor pathways to initiate cycle arrest and a differentiation program characteristic of senescent cells. We performed a two-stage, gain-of-function screen to select for the genes whose enhanced expressi
Autor:
Michael J. Emanuele, Michael N. Starnbach, Laura M. Sack, Madeleine G. Haff, Stephen J. Elledge, Andrew J. Olive, Jeffrey R. Barker
Publikováno v:
Cell Host & Microbe. 15:113-124
SummaryIntracellular pathogens directly alter host cells in order to replicate and survive. While infection-induced changes in host transcription can be readily assessed, posttranscriptional alterations are more difficult to catalog. We applied the g
Autor:
John C. Yoon, Laura M. Sack, Kristen E. Mengwasser, Andrew Wei Xu, Teresa Davoli, Stephen J. Elledge, Peter J. Park
Publikováno v:
Cell. 155:948-962
SummaryAneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here, we develop Tumor Suppressor and Oncogene (TUSON) Explorer, a com
Autor:
Kathleen A. Scorsone, Stephen J. Elledge, Anthony C. Liang, Yuyang Li, Qikai Xu, Yumei Leng, Thomas F. Westbrook, Timothy D. Martin, Ronald J. Bernardi, Laura M. Sack, Ting Chen, Mamie Z. Li, Kamila Naxerova, Kwok-Kin Wong, Teresa Davoli, Eric C. Wooten
Publikováno v:
Cell. 173:499-514.e23
Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic drivers that work primarily through dosage changes is a current challenge. Unrestrained proliferation is a critical hallmark of cancer. We constructed