Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Laura M. Nocka"'
Publikováno v:
eLife, Vol 12 (2023)
The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH) module connected by a proline-rich linker to a ‘Src module’, an SH3-SH2-kinase unit also found in Src-family kinases and Abl. We showed previously tha
Externí odkaz:
https://doaj.org/article/c60c916d064543008f2769b180012919
Autor:
Frank Hidalgo, Laura M Nocka, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffrey G Pelton, Susan Marqusee, David Wemmer, John Kuriyan
Publikováno v:
eLife, Vol 11 (2022)
Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61. Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified many other activating mutations (Bandaru et al., 2017). We now show t
Externí odkaz:
https://doaj.org/article/8fa21de2eb884f18b20d8654df44e43f
The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH) module connected by a proline-rich linker to a “Src module”, an SH2-SH3-kinase unit also found in Src-family kinases and Abl. We showed previously tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87790afab4d9c94cd74d4ee7c3b94b7b
https://doi.org/10.1101/2022.08.25.505243
https://doi.org/10.1101/2022.08.25.505243
Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions
Autor:
Catherine B Carbone, Ronald D. Vale, Jean K. Chung, Jay T. Groves, Laura M. Nocka, William Y. C. Huang, Atul N. Parikh
Publikováno v:
Biophys J
Lipid miscibility phase separation has long been considered to be a central element of cell membrane organization. More recently, protein condensation phase transitions, into three-dimensional droplets or in two-dimensional lattices on membrane surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d1fb8c5ded571e6ae66923e79330d3
https://doi.org/10.1016/j.bpj.2020.09.017
https://doi.org/10.1016/j.bpj.2020.09.017
Autor:
Chun-Wei Lin, Laura M. Nocka, Brittany L. Stinger, Joseph B. DeGrandchamp, L. J. Nugent Lew, Steven Alvarez, Henry T. Phan, Yasushi Kondo, John Kuriyan, Jay T. Groves
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(19)
We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface. The phase transition depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee1d61a726cbac4b29b5bf71f1ceabe
https://pubmed.ncbi.nlm.nih.gov/35507881
https://pubmed.ncbi.nlm.nih.gov/35507881
Autor:
Laura M Nocka, Frank Hidalgo, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffrey G Pelton, Susan Marqusee, David Wemmer, John Kuriyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d20b5cdea76b5a59e46beec05a786ccb
https://doi.org/10.7554/elife.76595.sa2
https://doi.org/10.7554/elife.76595.sa2
Autor:
Laura M Nocka, Frank Hidalgo, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffrey G Pelton, Susan Marqusee, David Wemmer, John Kuriyan
Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61. Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified many other activating mutations (Bandaru et al. eLife, 2017). We now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923b59f4f0a08325991301a170026033
https://doi.org/10.1101/2022.01.06.475190
https://doi.org/10.1101/2022.01.06.475190
Autor:
Chun-Wei Lin, Laura M. Nocka, Brittany Stinger, Joey DeGrandchamp, Nugent Lew, Steven Alvarez, Henry Phan, Yasushi Kondo, John Kuriyan, Jay T. Groves
We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface. The phase transition depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bde638683a3fcc1c476fec04919e667
https://doi.org/10.1101/2021.12.12.472247
https://doi.org/10.1101/2021.12.12.472247
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Autor:
Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison, John Kuriyan
Publikováno v:
eLife, Vol 4 (2015)
Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited B
Externí odkaz:
https://doaj.org/article/8e8d6a00ebf74762849d3409c8279eda