Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura M. L. Hawk"'
Autor:
Jay M. Pittman, Laura M. L. Hawk, Patrick C. Moore, Atul K. Srivastava, Joseph R. Sachleben, Andrew J. Hawk, Jonathan Zerweck, Joshua T.B. Williams, Stephen C. Meredith
Publikováno v:
Protein Sci
The mechanism by which a disordered peptide nucleates and forms amyloid is incompletely understood. A central domain of β‐amyloid (Aβ21–30) has been proposed to have intrinsic structural propensities that guide the limited formation of structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5eefbef0a98d33fcc3e5ca65c94fd28
https://doi.org/10.1002/pro.3778
https://doi.org/10.1002/pro.3778
Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment
Autor:
Andrew K. Urick, Andrea J. Wisniewski, Neeraj K. Mishra, Laura M. L. Hawk, William C. K. Pomerantz, Keith E. Arntson, Clifford T. Gee
Publikováno v:
Nat Protoc
Labeling of proteins with fluorinated amino acids and using fluorine-19 NMR greatly simplifies the NMR spectrum. Changes in the spectrum on interaction with ligands makes protein-observed fragment-based drug screening possible. NMR spectroscopy can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8b700b3e25a185ecdf0586a2193e07
https://doi.org/10.1038/nprot.2016.079
https://doi.org/10.1038/nprot.2016.079
Publikováno v:
RSC Advances. 6:95715-95721
Protein-observed 19F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cb3a2035c41c5ad295de39d7e143c6
https://doi.org/10.1039/c6ra21226c
https://doi.org/10.1039/c6ra21226c
Autor:
Laura M. L. Hawk, Melissa K. Cassel, Wei Zhang, Neeta Adhikari, Jennifer L. Hall, Shuai Liu, Andrew K. Urick, William C. K. Pomerantz, Neeraj K. Mishra, Camila O. dos Santos
Publikováno v:
ACS Chemical Biology. 10:2246-2256
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy. We describe a (19)F NMR dual screening method for small molecule disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a375d9035043fd5594ac1e633d94274b
https://doi.org/10.1021/acschembio.5b00483
https://doi.org/10.1021/acschembio.5b00483
Autor:
Ernst Schönbrunn, Laura M. L. Hawk, Tim Ward, James E. Bradner, Nana K. Offei-Addo, Ryan J. Herzig, Gunda I. Georg, Andrea J. Wisniewski, Norbert Berndt, Jiewei Jiang, Peiliang Zhao, Jun Qi, Thomas G. Scott, William C. K. Pomerantz, Clifford T. Gee, Alex M. Ayoub, Jin-Yi Zhu
Publikováno v:
Journal of medicinal chemistry. 60(12)
Chemical inhibition of epigenetic regulatory proteins BrdT and Brd4 is emerging as a promising therapeutic strategy in contraception, cancer, and heart disease. We report an easily synthesized dihydropyridopyrimidine pan-BET inhibitor scaffold, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0466fc0ba7eb73d4fd762e53889aa2
https://pubmed.ncbi.nlm.nih.gov/28696689
https://pubmed.ncbi.nlm.nih.gov/28696689
Publikováno v:
RSC advances. 6(98)
Protein-observed 19F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3146d7cb2834936b2dcda4a7772966c
https://pubmed.ncbi.nlm.nih.gov/28496971
https://pubmed.ncbi.nlm.nih.gov/28496971
Autor:
Jin-Yi Zhu, James E. Bradner, Norbert Berndt, Peiliang Zhao, Jun Qi, Clifford T. Gee, Ernst Schönbrunn, Gunda I. Georg, Laura M. L. Hawk, Timothy R. Ward, William C. K. Pomerantz, Jiewei Jiang, Andrea J. Wisniewski, Thomas G. Scott, Nana K. Offei-Addo, Ryan J. Herzig, Alex M. Ayoub
Publikováno v:
Journal of Medicinal Chemistry. 60:6458-6458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9899cb1968daaaeba2a06b14db2ee84
https://doi.org/10.1021/acs.jmedchem.7b00943
https://doi.org/10.1021/acs.jmedchem.7b00943