Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Laura M. Jenkins"'
Autor:
Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of
Externí odkaz:
https://doaj.org/article/ed54a9e793e64950bc11bf6731d8ff90
Autor:
Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh
Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0964e26d2798fd26b9ba222f278b1c36
https://doi.org/10.1158/0008-5472.c.6509868.v1
https://doi.org/10.1158/0008-5472.c.6509868.v1
Autor:
Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh
Growth curves of (i) HMEC-1 and MEEC cells in the presence or absence of 100pM recombinant Inhibin A over 7 days or (ii) HMEC-1 migration through fibronectin coated transwells for 6 hrs towards control serum free media or media containing 300 pM reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cbc9886f4412f12248899fc31bece5
https://doi.org/10.1158/0008-5472.22417524
https://doi.org/10.1158/0008-5472.22417524
Autor:
Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh
Quantification of parameters in the ovarian tissue array
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029386edc3bf324d84ffd604315ed3e1
https://doi.org/10.1158/0008-5472.22417509.v1
https://doi.org/10.1158/0008-5472.22417509.v1
Autor:
David K. Lau, John M. Mariadason, Laura M. Jenkins, Andrew Weickhardt, Margeaux Hodgson-Garms, Natalia Vukelic, Austen Lavis, Ian Luk, Paul Ioannidis
BackgroundMutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10-20% of metastatic urothelial carcinomas, and can confer sensitivity to FGFR inhibitors such as BGJ398 and erdafitinib. However, responses to these agents are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a28d37d5f58e2b24107906855f1e545
https://doi.org/10.21203/rs.3.rs-142420/v1
https://doi.org/10.21203/rs.3.rs-142420/v1
Autor:
Eugenia V. Broude, Michael L. Gatza, Jiaxin Liang, Alexander A. Chumanevich, Anne Serrao, Karthikeyan Mythreye, Laura M. Jenkins, Igor B. Roninson, Nam Y. Lee, Ben Horst
Publikováno v:
Oncogene. 37:4792-4808
CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD transcriptional activation and turnover through YAP1 recruitment. However, how the CDK8/YAP1 pathway influences SMAD1 response in cancer remains unclear. Here we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a32a6cf05f23e687f839eb9e0b3f106
https://doi.org/10.1038/s41388-018-0316-y
https://doi.org/10.1038/s41388-018-0316-y
Autor:
Priyanka Singh, Ben Horst, Balázs Győrffy, Laura M. Jenkins, Eugenia Broude, Shrikant Pradhan, Victoria Alers, Prabhjot Kaur, Karthikeyan Mythreye, Tapasya Srivastava, Nam Y. Lee, Nadine Hempel
Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af723ffea95bc36b4cffc6b5499d1276
https://europepmc.org/articles/PMC6510404/
https://europepmc.org/articles/PMC6510404/
Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a6ba339d21a16ef9e13fa1e7d72015
https://europepmc.org/articles/PMC5866756/
https://europepmc.org/articles/PMC5866756/
Autor:
Priyanka Singh, Laura M. Jenkins, Archana Varadaraj, Shreya Shah, Karthikeyan Mythreye, Kathleen O'Connell, Haley V. Flores, Nam Y. Lee
Hyperactive Wnt/β-catenin signaling is linked to cancer progression and developmental abnormalities, making identification of mechanisms controlling Wnt/β-catenin signaling vital. Transforming growth factor β type III receptor (TβRIII/betaglycan)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebac0d11b449e11dc274769410c640e
https://europepmc.org/articles/PMC5207267/
https://europepmc.org/articles/PMC5207267/
Autor:
Marcelo Ehrlich, Ayelet R. Amsalem-Zafran, Priyanka Singh, Anindya Chanda, Laura M. Jenkins, John Snider, Yoav I. Henis, Archana Varadaraj, Karthikeyan Mythreye, Nam Y. Lee
Publikováno v:
Molecular Biology of the Cell
There is increased recycling of soluble fibronectin from the cell surface for fibrillogenesis. This recycling is regulated by TGF-β in a transcription- and SMAD-independent manner via specific TβRII and integrin α5β1 interactions. The recycling o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21177cc181b641143c9ef306e8281294
https://pubmed.ncbi.nlm.nih.gov/28298487
https://pubmed.ncbi.nlm.nih.gov/28298487