Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Laura M. Gunsalus"'
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100410- (2023)
Summary: Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome wide. We developed a deep-learning strategy to
Externí odkaz:
https://doaj.org/article/664dcf7d1471438eb189123408b2644a
Autor:
Laura M. Gunsalus, Evonne McArthur, Ketrin Gjoni, Shuzhen Kuang, Maureen Pittman, John A. Capra, Katherine S. Pollard
Comparing chromatin contact maps is an essential step in quantifying how three-dimensional (3D) genome organization shapes development, evolution, and disease. However, no gold standard exists for comparing contact maps, and even simple methods often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9f6f1856bfa3ebbb388e857144b2e0
https://doi.org/10.1101/2023.04.04.535480
https://doi.org/10.1101/2023.04.04.535480
Publikováno v:
Journal of Medicinal Chemistry. 63:8705-8722
The accurate modeling and prediction of small molecule properties and bioactivities depend on the critical choice of molecular representation. Decades of informatics-driven research have relied on expert-designed molecular descriptors to establish qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804ad54af01f42bbf02e8b3466907e40
https://doi.org/10.1021/acs.jmedchem.0c00385
https://doi.org/10.1021/acs.jmedchem.0c00385
Publikováno v:
Journal of medicinal chemistry. 63(16)
The accurate modeling and prediction of small molecule properties and bioactivities depend on the critical choice of molecular representation. Decades of informatics-driven research have relied on expert-designed molecular descriptors to establish qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7db03618c0f2f6982980ba9dd947f2db
https://pubmed.ncbi.nlm.nih.gov/32366098
https://pubmed.ncbi.nlm.nih.gov/32366098
Autor:
Zun Zar Chi Naing, Maru Jaime-Garza, Taia S. Wu, Laurel S Estes, Martin Kampmann, Eric D. Chow, Taylor B. Cavazos, Miriam A. Goldman, Yessica K. Gomez, William F. DeGrado, Stephanie A. Wankowicz, Matthew C. Johnson, Christa Caggiano, Christina A. Stephens, Bryan Faust, Daniel Barrero, Lakshmi E. Miller-Vedam, Elizabeth E. McCarthy, Kyle E. Lopez, Sy Redding, Jenna Pellegrino, Elissa A Fink, Wren Saylor, Alison M Maxwell, Hayarpi Torosyan, Jared Lumpe, Robert W. Newberry, George C. Hartoularos, Daniel M. C. Schwarz, Calla Martyn, Laura M. Gunsalus, Jack Strickland, Maureen Pittman, Taylor Arhar, Andrew F. Kung, Daniel R. Wong, Garrett Wong, Nishith R. Reddy, Matthew G. Jones, Aji Palar, Erik J. Navarro, Nick Hoppe, M. Grace Gordon, Douglas R. Wassarman, Jean Costello, Adam Catching
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 8
ACS chemical biology, vol 15, iss 8
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b