Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Laura M. Alcântara"'
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 430-439 (2018)
Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect more than 30 million people worldwide and cause high mortality and morbi
Externí odkaz:
https://doaj.org/article/b6d1ad93ae1b4bf9add8db00d0cf5c03
Autor:
Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
Externí odkaz:
https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394
Autor:
Laura M. Alcântara, Thalita C. S. Ferreira, Vanessa Fontana, Eric Chatelain, Carolina B. Moraes, Lucio H. Freitas-Junior
Publikováno v:
Molecules, Vol 25, Iss 11, p 2551 (2020)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be use
Externí odkaz:
https://doaj.org/article/ae414627f8eb4f7cb62110520c16a223
Autor:
Carolina B. Moraes, Bradford S. McGwire, Paula Bittencourt-Cunha, Sergio Schenkman, Bijay Kumar Jha, Normanda Souza-Melo, Fernanda Midori Abukawa, Gregory Pedroso Dos Santos, Laura M. Alcântara, Nilmar Silvio Moretti
Publikováno v:
Cell Microbiol
Infection by Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, depends on reactive oxygen species (ROS), which has been described to induce parasite proliferation in mammalian host cells. It is unknown how the parasite manages to
Autor:
Thalita Camêlo da Silva Ferreira, Vanessa Fontana, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Junior, Eric Chatelain
Publikováno v:
Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be use
Autor:
Nilmar Silvio Moretti, Laura M. Alcântara, Milena Botelho Pereira Soares, Sergio Schenkman, Rino Ragno, Carolina B. Moraes, Lucio H. Freitas-Junior, Nicola Mautone, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Antonello Mai, Caio Haddad Franco, Tanira Matutino Bastos
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10
Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, affecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to causing several side effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24b0eb23df1cb4b5d68310a7131e38
http://hdl.handle.net/11573/1401342
http://hdl.handle.net/11573/1401342
Autor:
Joaquín María Campos Rosa, Leonardo B Federico, Carlos Henrique Tomich de Paula da Silva, Carolina B. Moraes, Laura M. Alcântara, Lucio H. Freitas-Junior
Publikováno v:
POJ Pharmaceutical Sciences. :01-06
Calcium channel blockage as a therapeutic strategy for treatment of leishmaniasis has demonstrated a promising pathway of treatment for this pathology. In this work, virtual screening approaches have been performed in several databases of commerciall
Autor:
Monica S. Sá, Rebecca C. Wade, Claudia Danielli Pereira Bertolacini, Puneet Saxena, Bruno dos Santos Pascoalino, Markus Wolf, Ulrike Wittig, Wolfgang Müller, William N. Hunter, Anabela Cordeiro-da-Silva, Maria Paola Costi, Ina Pöhner, Jeanette Reinshagen, Véronique Hannaert, Nuno Santarém, Pasquale Linciano, Carolina B. Moraes, Philip Gribbon, Alice Dawson, Gesa Witt, Vanessa Fontana, Stefania Ferrari, Laura M. Alcântara, Giuseppe Cannazza, G. Landi, Bernhard Ellinger, Maria Kuzikov, Paul A.M. Michels, Stefano Mangani, David Costa, Erika Nerini, Birte Behrens, Sandra Lazzari, Cecilia Pozzi, Flavio Di Pisa, Lucio H. Freitas-Junior, Luca Costantino, Rosaria Luciani, Sheraz Gul
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (T
Autor:
Lucio H. Freitas-Junior, Eric Chatelain, Carolina B. Moraes, Caio Haddad Franco, Laura M. Alcântara
Publikováno v:
Tropical Medicine and Infectious Disease; Volume 4; Issue 2; Pages: 82
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 82 (2019)
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 82 (2019)
Cell-based screening has become the major compound interrogation strategy in Chagas disease drug discovery. Several different cell lines have been deployed as host cells in screening assays. However, host cell characteristics and host-parasite intera
Autor:
Carolina B. Moraes, Laura M. Alcântara
Publikováno v:
Methods in Molecular Biology ISBN: 9781493992096
High content analysis enables automated, robust, and unbiased evaluation of in vitro Leishmania infection. Here, we describe a protocol based on the infection of THP-1 macrophages with Leishmania promastigotes and the quantification of parasite load
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9493da17fd494ddbaadf376104643e8
https://doi.org/10.1007/978-1-4939-9210-2_15
https://doi.org/10.1007/978-1-4939-9210-2_15