Výsledky vyhledávání - "Laura M Wanner"

Akademický článek

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Autor: Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)

There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Al

Externí odkaz: https://doaj.org/article/60298f029db949189b12f9558abf609f

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Akademický článek

Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.

Autor: Jonathan E Nuss, Kylene Kehn-Hall, Ashwini Benedict, Julie Costantino, Michael Ward, Brian D Peyser, Cary J Retterer, Lyal E Tressler, Laura M Wanner, Hugh F McGovern, Anum Zaidi, Scott M Anthony, Krishna P Kota, Sina Bavari, Ramin M Hakami

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e93483 (2014)

Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can cause near 100% abortion rates and recent outbreaks in naïve human populations have sugges

Externí odkaz: https://doaj.org/article/c96143c0a8d945fcb90fafb7f6419a2f

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Akademický článek

Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors

Autor: Sina Bavari, Cary J. Retterer, Edna Torres-Melendez, Sarah J. Sandwick, Laura M. Wanner, Lyal E. Tressler, Jonathan E. Nuss, Gordon Ruthel, James C. Burnett

Publikováno v: Toxins, Vol 3, Iss 3, Pp 207-217 (2011)

Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associ

Externí odkaz: https://doaj.org/article/9870667b3dd6453db0a5f49a6ad142f7

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Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons

Autor: Lino Tessarollo, Krishna P. Kota, James C. Burnett, Hao T. Du, Rekha G. Panchal, Jonathan E. Nuss, Brian D. Peyser, Laura M. Wanner, Glenn Y. Gomba, Erkan Kiris, Rick Gussio, Christopher D. Kane, Sina Bavari

Publikováno v: Neurotoxicity Research. 27:384-398

Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f38adaa5adbb8ab11f1aae387bd391b
https://doi.org/10.1007/s12640-015-9526-z

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The Osmolyte Trimethylamine N-Oxide (TMAO) Increases the Proteolytic Activity of Botulinum Neurotoxin Light Chains A, B, and E: Implications for Enhancing Analytical Assay Sensitivity

Autor: Jonathan E. Nuss, Sina Bavari, Laura M. Wanner, Lyal E. Tressler

Publikováno v: SLAS Discovery. 15:928-936

Botulism, the disease caused by botulinum neurotoxins (BoNTs), secreted by the spore-forming, anaerobic bacteria Clostridium botulinum, has been associated with food poisoning for centuries. In addition, the potency of BoNTs coupled with the current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fe914326c91d0eb0e383cb7db8dbb3
https://doi.org/10.1177/1087057110374996

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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Autor: Glenn Y. Gomba, Rick Gussio, James C. Burnett, Sina Bavari, Christopher D. Kane, Michael F. Maestre, Jonathan E. Nuss, Stephanie M. Stanford, Lisa H. Cazares, Lino Tessarollo, Nunzio Bottini, Hao T. Du, Rekha G. Panchal, Laura M. Wanner, Erkan Kiris

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00505bd6450956c5ec271c4bd68fe7f
http://europepmc.org/articles/PMC4462581?pdf=render

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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Autor: Glenn Y. Gomba, Veronica Soloveva, Rekha G. Panchal, Christopher D. Kane, Laura M. Wanner, Krishna P. Kota, Erkan Kiris, Sina Bavari

Publikováno v: Journal of Visualized Experiments.

Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic neurotransmitter release. Botulinum neurotoxin serotype A (BoNT/A) is a zinc metalloprotease tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e9e1246c59893bead757f38c9de1fa
https://doi.org/10.3791/51915-v

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Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency

Autor: Gordon Ruthel, Michelle M. Butler, Laura M. Wanner, Sina Bavari, Jonathan E. Nuss, Norton P. Peet, Steven C. Cardinale, Ramdas Pai, Terry L. Bowlin, Bing Li

Publikováno v: The botulinum journal. 2(1)

Botulinum Neurotoxins (BoNTs) are used therapeutically and in cosmetics, providing potential for bioterrorist activity, thus driving the search for small-molecule BoNT inhibitors. This report describes a 70,000-compound screen for inhibition of BoNT/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2725fd20a04d81d30d97985f8f0f61
https://pubmed.ncbi.nlm.nih.gov/23205055

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Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

Autor: Krishna P. Kota, Lino Tessarollo, Dawn C. I. Koh, Sina Bavari, Rick Gussio, Jonathan E. Nuss, Edna Torres-Melendez, James C. Burnett, Erkan Kiris, Laura M. Wanner

Botulinum neurotoxins (BoNTs) inhibit cholinergic synaptic transmission by specifically cleaving proteins that are crucial for neurotransmitter exocytosis. Due to the lethality of these toxins, there are elevated concerns regarding their possible use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6e01f0fe5e67d40a493bd1f266d94e
https://europepmc.org/articles/PMC3081902/

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A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus

Autor: Rick Gussio, Richard J. Sciotti, Donatella Taramelli, James C. Burnett, Charlotte A. Lanteri, Dejan Opsenica, Nicoletta Basilico, Igor Opsenica, Nina M. Todorović, Montip Gettayacamin, Laura M. Wanner, Sina Bavari, Jonathan E. Nuss, Bogdan A. Šolaja, Rekha G. Panchal

Publikováno v: Journal of Medicinal Chemistry

A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of the botulinum neurotoxin serotype A light chain metalloprotease. Subsequently, a variety of derivatives of this chemotype were synthesized to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031f4c5a7188b288ac83f061e5b994c1
https://cer.ihtm.bg.ac.rs/handle/123456789/901

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