Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Laura M Snell"'
Autor:
Cameron R Cunningham, Ameya Champhekar, Michael V Tullius, Barbara Jane Dillon, Anjie Zhen, Justin Rafael de la Fuente, Jonathan Herskovitz, Heidi Elsaesser, Laura M Snell, Elizabeth B Wilson, Juan Carlos de la Torre, Scott G Kitchen, Marcus A Horwitz, Steven J Bensinger, Stephen T Smale, David G Brooks
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005356 (2016)
Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1 that attenuate antiviral T cell responses. Inhibiting these suppressive signals enhances T cel
Externí odkaz:
https://doaj.org/article/6cc1d512b71d4350b891aaacda9d2b44
Autor:
Aryamav Pattnaik, Adeeba H. Dhalech, Stephanie A. Condotta, Caleb Corn, Martin J. Richer, Laura M. Snell, Christopher M. Robinson
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundBiological sex plays an integral role in the immune response to various pathogens. The underlying basis for these sex differences is still not well defined. Here, we show that Coxsackievirus B3 (CVB3) induces a viral-specific CD4+ T cell re
Externí odkaz:
https://doaj.org/article/e66c6ee82112422b86e1833c06e90ad2
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna C. Bertol, Madeleine Carew, Sabelo Lukhele, Laura M. Snell, Wenxi Xu, Giselle M. Boukhaled, Heidi Elsaesser, Marie Jo Halaby, Naoto Hirano, Tracy L. McGaha, David G. Brooks
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113047- (2023)
Summary: CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate that CD4 TTS cells are quickly primed and begin to divide following tumor initiati
Externí odkaz:
https://doaj.org/article/e4149f45150d4ef1af757d28b5084332
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna Bertol, Madeleine Carew, Sabelo Lukhele, Laura M Snell, Wenxi Xu, Giselle M Boukhaled, Heidi Elsaesser, Marie jo Halaby, Naoto Hirano, Tracy L McGaha, David G Brooks
Publikováno v:
bioRxiv
CD4 T cells are important effectors of anti-tumor immunity, yet the regulation of CD4 tumor-specific T (TTS) cells during cancer development is still unclear. We demonstrate that CD4 TTScells are initially primed in the tumor draining lymph node and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc68d8039b703b05f19324e33bbb107
https://europepmc.org/articles/PMC10153152/
https://europepmc.org/articles/PMC10153152/
Autor:
Laura M. Snell, Ivan Osokine, Douglas H. Yamada, Justin Rafael De la Fuente, Heidi J. Elsaesser, David G. Brooks
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3286-3296 (2016)
Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically l
Externí odkaz:
https://doaj.org/article/38afc539859f41e0a03d88bba858a20b
Autor:
Bethany L. MacLeod, W. Xu, Giselle Boukhaled, Sabelo Lukhele, Diala Abd-Rabbo, Mengdi Guo, Laura M. Snell, Sara Nejat, Heidi Elsaesser, Tracy L. McGaha, Slava Epelman, Kebria Hezaveh, David G. Brooks, Ramanandan Prabhakaran, Nirmin Alsahafi
Publikováno v:
Nature Immunology. 22:1524-1537
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T (TH) cell responses or the ability to
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
CD30 is a tumor necrosis factor receptor (TNFR) family member whose expression is associated with Hodgkin’s disease, anaplastic large cell lymphomas, and other T and B lymphoproliferative disorders in humans. A limited number of studies have assess
Externí odkaz:
https://doaj.org/article/748a480ef8f34e6c876f94559660f069
Autor:
Laura M, Snell
Publikováno v:
Immunity. 55(7)
How CD4
Autor:
Sabelo, Lukhele, Diala Abd, Rabbo, Mengdi, Guo, Jian, Shen, Heidi J, Elsaesser, Rene, Quevedo, Madeleine, Carew, Ramy, Gadalla, Laura M, Snell, Lawanya, Mahesh, M Teresa, Ciudad, Bryan E, Snow, Annick, You-Ten, Jillian, Haight, Andrew, Wakeham, Pamela S, Ohashi, Tak W, Mak, Weiguo, Cui, Tracy L, McGaha, David G, Brooks
Publikováno v:
Immunity. 55(12)
Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback circuits that impede control of cancer growth. Here, we sought to determine how these opposing p