Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Laura M Sanz"'
Autor:
Laura M Sanz, Benigno Crespo, Cristina De-Cózar, Xavier C Ding, Jose L Llergo, Jeremy N Burrows, Jose F García-Bustos, Francisco-Javier Gamo
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30949 (2012)
Chemotherapy is still the cornerstone for malaria control. Developing drugs against Plasmodium parasites and monitoring their efficacy requires methods to accurately determine the parasite killing rate in response to treatment. Commonly used techniqu
Externí odkaz:
https://doaj.org/article/f895316721144aa198f0982b7d046429
Autor:
Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito
Externí odkaz:
https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75
Autor:
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth
Externí odkaz:
https://doaj.org/article/0c48607312374096801bf91f077ff9c0
Autor:
Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Benzoxaboroles have been shown to be active against different pathogens. Here, the authors show that the benzoxaborole AN3661 inhibitsPlasmodium falciparum in vitroand in mouse models, and identify a homologue of a mammalian cleavage and polyadenylat
Externí odkaz:
https://doaj.org/article/0a61f14362894ce98b395b6ccf63a199
Autor:
Prapon Wilairat, Maria G. Gomez-Lorenzo, Thanat Chookajorn, Kesinee Chotivanich, Krittikorn Kümpornsin, Laura M. Sanz, Cristina de Cozar, Marcus C. S. Lee, Namfon Kotanan, Duangkamon Loesbanluechai, Nicholas J. White, Francisco-Javier Gamo
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 186-190 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Emerging artemisinin resistance in Plasmodium falciparum malaria has the potential to become a global public health crisis. In Southeast Asia, this phenomenon clinically manifests in the form of delayed parasite clearance following artemisinin treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d3e099e19347efd4515052b596b009
http://www.sciencedirect.com/science/article/pii/S2211320721000488
http://www.sciencedirect.com/science/article/pii/S2211320721000488
Autor:
Atsuko Ochida, Masahiro Kamaura, Angelika Sturm, Xue Chen, Karen L. White, Benoît Laleu, Binglin Wang, Benigno Crespo, Yuichiro Akao, Nobuo Cho, Gong Chen, Vicky M. Avery, Sergio Wittlin, Laura M. Sanz, Francis C. K. Chiu, Koen J. Dechering, David M. Shackleford, Kasiram Katneni, Sandra Duffy, Leonardo Lucantoni, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:12582-12602
A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure-activity relationship studies led to identification of a potent inhibitor 19f, 95-fold more potent than the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf33a3e0cc4d27cbcc8fe60cf19f5e
https://doi.org/10.1021/acs.jmedchem.1c00441
https://doi.org/10.1021/acs.jmedchem.1c00441
Autor:
Vicky M. Avery, Tomas Yeo, Susan A. Charman, David A. Fidock, Anne-Catrin Uhlemann, Sandra Duffy, Sumanta Dey, Sergio Wittlin, Laura M. Sanz, Rafael Victorio Carvalho Guido, Benigno Crespo, Alisje Churchyard, Atsuko Ochida, Jacquin C. Niles, Anna Caroline Campos Aguiar, Yuichiro Akao, Jake Baum, Karen L. White, Leonardo Lucantoni, Josefine Striepen, Masanori Okaniwa, Angelika Sturm, Dhelio Batista Pereira, Akira Shibata, Koen J. Dechering, David M. Shackleford, Sachel Mok, Benoît Laleu
Publikováno v:
ACS
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives representing a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd99b0f8a80b7cd225661da3769c746
https://doi.org/10.1021/acsinfecdis.1c00020
https://doi.org/10.1021/acsinfecdis.1c00020
Autor:
Stephan Meister, Vicky M. Avery, Yevgeniya Antonova-Koch, Elizabeth A. Winzeler, Benigno Crespo, David Waterson, Alan H. Fairlamb, Jennifer Riley, Neil R. Norcross, Laura M. Sanz, Irene Hallyburton, Julie A. Frearson, Ian H. Gilbert, Paul Willis, Francisco-Javier Gamo, Simon F. Campbell, Suzanne Norval, Maria Osuna-Cabello, Cristina de Cozar, Robert E. Sinden, David W. Gray, Sandra Duffy, Andrea Ruecker, Caroline Wilson, Michael J. Delves, Beatriz Baragaña, Daniel A. Fletcher, Kevin D. Read
Publikováno v:
Chemmedchem
Herein we describe the optimization of a phenotypic hit against Plasmodium falciparum based on an aminoacetamide scaffold. This led to N‐(3‐chloro‐4‐fluorophenyl)‐2‐methyl‐2‐{[4‐methyl‐3‐(morpholinosulfonyl)phenyl]amino}propanam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc14ab7154c8bef7afa4b081371bf96
https://doi.org/10.1002/cmdc.201900329
https://doi.org/10.1002/cmdc.201900329
Autor:
Mohammed H Cherkaoui-Rbati, Roland A. Cooper, Nina F. Gnädig, Iñigo Angulo-Barturen, Tomas Yeo, Sridevi Bashyam, Rintis Noviyanti, James M. Murithi, Gilles Courtemanche, Philip J. Rosenthal, María Belén Jiménez-Díaz, Laurent Sallé, Cécile Pascal, Rita Merino, Gilles Tuffal, Jutta Marfurt, Sergio Wittlin, Shivendra Singh, Marie José Cabanis, Lidiya Bebrevska, Jean Michel Augereau, Laura M. Sanz, Jean Michel Guillon, Sachel Mok, Paul Desert, Kelly Rubiano, Alain Pellet, Jacquin C. Niles, Guillaume Louit, Anne-Catrin Uhlemann, Nadir Bessila, Thierry Vermat, Simon Campbell, Didier Leroy, Tanguy Bozec, Jérôme Menegotto, Michel Doubovetzky, Xavier Boulenc, Benjamin Blasco, Nathalie Gobeau, Francisco-Javier Gamo, Sylvie Klieber, Elie Giraud, Jayan Joseph, Charisse Flerida A. Pasaje, Delphine Baud, Laurent Fraisse, Fanny Escudié, Jade Bath, Marie Françoise Nicolas, Mélanie Rouillier, David A. Fidock, Grennady Wirjanata, Ric N. Price, Patrick K Tumwebaze
The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c2e27d8190f65306f8587a21d03126
https://ora.ox.ac.uk/objects/uuid:39d2c646-efac-4c3d-bdef-8cf1ff7f497f
https://ora.ox.ac.uk/objects/uuid:39d2c646-efac-4c3d-bdef-8cf1ff7f497f
Autor:
Julie M. J. Verhoef, Rosemary Rochford, Philip J. Rosenthal, Graham P. Trevitt, Patrick K Tumwebaze, Barcelo C, Manuel Llinás, Jacquin C. Niles, Koen J. Dechering, Henderson R, Roger Bonnert, Dhelio Batista Pereira, Anna Caroline Campos Aguiar, Huijs T, Judith M. Bolscher, David A. Fidock, Tomas Yeo, Robert W. Sauerwein, Pasaje Cfa, Jake Baum, Patrick A. M. Jansen, Brice Campo, Roland A. Cooper, Taco W. A. Kooij, de Vries Le, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Francisco J. Gamo, Josefine Striepen, Pedro H. H. Hermkens, Sergio Wittlin, Rafael Victorio Carvalho Guido, Kelly Rubiano, Justin Munro, Fernandez Bc, Laura M. Sanz, Karin M. J. Koolen, J. Schalkwijk, Alisje Churchyard
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defffb247aaafa1d1e8ba557aa91a1d8
https://doi.org/10.1101/2021.05.12.443866
https://doi.org/10.1101/2021.05.12.443866