Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Laura M Machesky"'
Autor:
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
Publikováno v:
eLife, Vol 13 (2024)
Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 activation, conferring enhanced migratory and proliferative capacity as we
Externí odkaz:
https://doaj.org/article/3ef6ce7cbce2496185636f37f848fb70
Autor:
Shashi Prakash Singh, Peter A Thomason, Sergio Lilla, Matthias Schaks, Qing Tang, Bruce L Goode, Laura M Machesky, Klemens Rottner, Robert H Insall
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000774 (2020)
The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both
Externí odkaz:
https://doaj.org/article/bdfc9a7e62504de482bc8b2512da123b
Autor:
Andrew J Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J Faller, Douwe M Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C Bennett, Owen J Sansom, Robert Herd, Robert Jones, Laura M Machesky, Michael J O Wakelam, David A Knecht, Robert H Insall
Publikováno v:
PLoS Biology, Vol 12, Iss 10, p e1001966 (2014)
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potent
Externí odkaz:
https://doaj.org/article/d3993f4afdf3405ab98357b4e65f0fe6
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31141 (2012)
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in
Externí odkaz:
https://doaj.org/article/a5e57de7038d49d480ef17bb33be33eb
Autor:
Xinzi Yu, Laura M Machesky
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30605 (2012)
The ability of tumor cells to invade is one of the hallmarks of the metastatic phenotype. To elucidate the mechanisms by which tumor cells acquire an invasive phenotype, in vitro assays have been developed that mimic the process of cancer cell invasi
Externí odkaz:
https://doaj.org/article/b2714181e03f417ab7ff3f46c9330161
Autor:
Simon D J Calaminus, Amelie V Guitart, Amy Sinclair, Hannah Schachtner, Steve P Watson, Tessa L Holyoake, Kamil R Kranc, Laura M Machesky
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51361 (2012)
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology. However, in the present study we have emplo
Externí odkaz:
https://doaj.org/article/c36bdc75aa094263aeb4f2c1eb954105
Publikováno v:
PLoS Pathogens, Vol 7, Iss 4, p e1001332 (2011)
Infection of host cells by pathogenic microbes triggers signal transduction pathways leading to a multitude of host cell responses including actin cytoskeletal re-arrangements and transcriptional programs. The diarrheagenic pathogens Enteropathogenic
Externí odkaz:
https://doaj.org/article/cdd21ebf408e4657b3111085d9cda86d
Autor:
Emma L. Wilkinson, Louise C. Brennan, Olivia J. Harrison, Zoe Crane‐Smith, Philippe Gautier, Margaret A. Keighren, Peter Budd, Karthic Swaminathan, Laura M. Machesky, Sarah L. Allinson, Ian J. Jackson, Richard L. Mort
Publikováno v:
Pigment Cell & Melanoma Research. 36:71-77
Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of
Autor:
Laura M. Machesky, Michael Olson
The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334fb2cae480c11ab233693cf45b7b64
https://doi.org/10.32920/21985082.v1
https://doi.org/10.32920/21985082.v1
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e352907f850bed2de52d673abe89425
https://doi.org/10.1007/978-1-0716-3056-3_11
https://doi.org/10.1007/978-1-0716-3056-3_11