Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Laura M, Woods"'
Autor:
Revathy Ramachandran, Shakhzada Ibragimova, Laura M. Woods, Tamader AlHouqani, Roshna Lawrence Gomez, Fabrizio Simeoni, Mahmood Y. Hachim, Tim C.P. Somervaille, Anna Philpott, Jason S. Carroll, Fahad R. Ali
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110500- (2024)
Summary: Triple-negative breast cancer (TNBC) is characterized by lack of the estrogen (ER) receptor, progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2), and standard receptor-targeted therapies are ineffective. FOXC1, a
Externí odkaz:
https://doaj.org/article/95f276360fa1442aa803bad570a00ca8
Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
Autor:
Laura M. Woods, Fahad R. Ali, Roshna Gomez, Igor Chernukhin, Daniel Marcos, Lydia M. Parkinson, Ahmad N. Abou Tayoun, Jason S. Carroll, Anna Philpott
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often associated with neurobla
Externí odkaz:
https://doaj.org/article/89eed2ceb61f4f35ab523721e0a30e0a
Autor:
Fiona C. Ingleby, Laura M. Woods, Iain M. Atherton, Matthew Baker, Lucy Elliss-Brookes, Aurélien Belot
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background People living in more deprived areas of high-income countries have lower cancer survival than those in less deprived areas. However, associations between individual-level socio-economic circumstances and cancer survival are relati
Externí odkaz:
https://doaj.org/article/cf7ec4b1a058408da2d4e5a06461b36b
Autor:
Lydia M. Parkinson, Sarah L. Gillen, Laura M. Woods, Lewis Chaytor, Daniel Marcos, Fahad R. Ali, Jason S. Carroll, Anna Philpott
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. Achaete-scute homolog 1 (ASCL1) is a proneural
Externí odkaz:
https://doaj.org/article/86959bc2c5464a4c828c6b43b05a923a
Autor:
Roshna Lawrence Gomez, Laura M. Woods, Revathy Ramachandran, Ahmad N. Abou Tayoun, Anna Philpott, Fahad R. Ali
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic acid treatment is part of the maint
Externí odkaz:
https://doaj.org/article/388d8674c43942e7bdb8e70674963ce6
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background Patients living in more deprived localities have lower cancer survival in England, but the role of individual health status at diagnosis and the utilisation of primary health care in explaining these differentials has not been wid
Externí odkaz:
https://doaj.org/article/dac680e501274a679e5f0f80dec40056
Autor:
Aurélien Belot, Matthew Baker, Fiona C Ingleby, Laura M Woods, Iain M Atherton, Lucy Ellis-Brookes
Publikováno v:
BMJ Open, Vol 12, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/dc6ff3d842ad4efc9ba239176c25ef2a
Autor:
Fiona C. Ingleby, Laura M. Woods, Iain M. Atherton, Matthew Baker, Lucy Elliss-Brookes, Aurélien Belot
Publikováno v:
SSM: Population Health, Vol 14, Iss , Pp 100815- (2021)
People who live in more deprived areas have poorer health outcomes, and this inequality is a major driver of health and social policy. Many interventions targeting these disparities implicitly assume that poorer health is predominantly associated wit
Externí odkaz:
https://doaj.org/article/248b934988fc443596e534f4fbd6f830
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0251876 (2021)
BackgroundPancreatic cancer (PC) represents a substantial public health burden. Pancreatic cancer patients have very low survival due to the difficulty of identifying cancers early when the tumour is localised to the site of origin and treatable. Rec
Externí odkaz:
https://doaj.org/article/41d9c426ab544c6e80ebf8ef8108b0ff
Autor:
Lucy Elliss-Brookes, Aurélien Belot, Matthew Baker, Fiona C Ingleby, Iain Atherton, Laura M Woods
Publikováno v:
BMJ Open, Vol 10, Iss 11 (2020)
Objectives Most research on health inequalities uses aggregated deprivation scores assigned to the small area where the patient lives; however, the concordance between aggregate area-level deprivation measures and personal deprivation experienced by
Externí odkaz:
https://doaj.org/article/d23e150596e14689b1ec0aab03437667