Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Laura M, Fiori"'
Autor:
Rixing Lin, Haruka Mitsuhashi, Laura M. Fiori, Ryan Denniston, El Cherif Ibrahim, Catherine Belzung, Naguib Mechawar, Gustavo Turecki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Major depressive disorder (MDD) is a complex and potentially debilitating illness whose etiology and pathology remains unclear. Non-coding RNAs have been implicated in MDD, where they display differential expression in the brain and the peri
Externí odkaz:
https://doaj.org/article/0a93bbaa031e4a86a7bb33fcf2a1e7a1
Autor:
Malosree Maitra, Haruka Mitsuhashi, Reza Rahimian, Anjali Chawla, Jennie Yang, Laura M. Fiori, Maria Antonietta Davoli, Kelly Perlman, Zahia Aouabed, Deborah C. Mash, Matthew Suderman, Naguib Mechawar, Gustavo Turecki, Corina Nagy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outc
Externí odkaz:
https://doaj.org/article/389b6a1bbe614ddfb2f428e68a2abf33
Autor:
Rixing Lin, Aron Kos, Juan Pablo Lopez, Julien Dine, Laura M Fiori, Jennie Yang, Yair Ben-Efraim, Zahia Aouabed, Pascal Ibrahim, Haruka Mitsuhashi, Tak Pan Wong, El Cherif Ibrahim, Catherine Belzung, Pierre Blier, Faranak Farzan, Benicio N Frey, Raymond W Lam, Roumen Milev, Daniel J Muller, Sagar V Parikh, Claudio Soares, Rudolf Uher, Corina Nagy, Naguib Mechawar, Jane A Foster, Sidney H Kennedy, Alon Chen, Gustavo Turecki
Publikováno v:
eLife, Vol 12 (2023)
Pharmacotherapies for the treatment of major depressive disorder were serendipitously discovered almost seven decades ago. From this discovery, scientists pinpointed the monoaminergic system as the primary target associated with symptom alleviation.
Externí odkaz:
https://doaj.org/article/40f97f541aac443b8777dc3821cea8f3
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285123 (2023)
BackgroundMajor depressive disorder (MDD) is a leading cause of disability worldwide, and is commonly treated with antidepressant drugs (AD). Although effective, many patients fail to respond to AD treatment, and accordingly identifying factors that
Externí odkaz:
https://doaj.org/article/d0d17bb593c24c90a67cd80072d2a150
Autor:
Rixing Lin, Juan Pablo Lopez, Cristiana Cruceanu, Caroline Pierotti, Laura M. Fiori, Alessio Squassina, Caterina Chillotti, Christoph Dieterich, Nikolaos Mellios, Gustavo Turecki
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Gene expression dysregulation in the brain has been associated with bipolar disorder, but little is known about the role of non-coding RNAs. Circular RNAs are a novel class of long noncoding RNAs that have recently been shown to be important
Externí odkaz:
https://doaj.org/article/e1375c7f13de497ab883d11db3beb395
Autor:
Antoine Yrondi, Laura M. Fiori, Nikita Nogovitsyn, Stefanie Hassel, Jean François Théroux, Zahia Aouabed, Benicio N. Frey, Raymond W. Lam, Roumen Milev, Daniel J. Müller, Jane A. Foster, Claudio Soares, Susan Rotzinger, Stephen C. Strother, Glenda M. MacQueen, Stephen R. Arnott, Andrew D. Davis, Mojdeh Zamyadi, Jacqueline Harris, Sidney H. Kennedy, Gustavo Turecki
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract The pathophysiology of major depressive disorder (MDD) encompasses an array of changes at molecular and neurobiological levels. As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory mol
Externí odkaz:
https://doaj.org/article/065d0f0350c1425896a0f36f31046e58
Autor:
Laura M. Fiori, Massimiliano Orri, Zahia Aouabed, Jean François Théroux, Rixing Lin, Corina Nagy, Benicio N. Frey, Raymond W. Lam, Glenda M. MacQueen, Roumen Milev, Daniel J. Müller, Sagar V. Parikh, Susan Rotzinger, Rudolf Uher, Jane A. Foster, Sidney H. Kennedy, Gustavo Turecki
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Identifying biomarkers of antidepressant response may advance personalized treatment of major depressive disorder (MDD). We aimed to identify longitudinal changes in gene expression associated with response to antidepressants in a sample of
Externí odkaz:
https://doaj.org/article/ccff387344a94c51b5edcadeaaf37c30
Autor:
Raoul Belzeaux, Victor Gorgievski, Laura M. Fiori, Juan Pablo Lopez, Julien Grenier, Rixing Lin, Corina Nagy, El Chérif Ibrahim, Eduardo Gascon, Philippe Courtet, Stéphane Richard-Devantoy, Marcelo Berlim, Eduardo Chachamovich, Jean-François Théroux, Sylvie Dumas, Bruno Giros, Susan Rotzinger, Claudio N. Soares, Jane A. Foster, Naguib Mechawar, Gregory G. Tall, Eleni T. Tzavara, Sidney H. Kennedy, Gustavo Turecki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
It is not fully understood why some patients respond or do not respond to antidepressant treatment. Here the authors show that in the blood of individuals with depression, GPR56 expression increases in responders to antidepressant treatment, but not
Externí odkaz:
https://doaj.org/article/3469c4a94a4c4f539ae3e87d5f59f012
Autor:
Juan Pablo Lopez, Laura M. Fiori, Cristiana Cruceanu, Rixing Lin, Benoit Labonte, Hannah M. Cates, Elizabeth A. Heller, Vincent Vialou, Stacy M. Ku, Christophe Gerald, Ming-Hu Han, Jane Foster, Benicio N. Frey, Claudio N. Soares, Daniel J. Müller, Faranak Farzan, Francesco Leri, Glenda M. MacQueen, Harriet Feilotter, Kathrin Tyryshkin, Kenneth R. Evans, Peter Giacobbe, Pierre Blier, Raymond W. Lam, Roumen Milev, Sagar V. Parikh, Susan Rotzinger, Steven C. Strother, Cathryn M. Lewis, Katherine J. Aitchison, Gayle M. Wittenberg, Naguib Mechawar, Eric J. Nestler, Rudolf Uher, Sidney H. Kennedy, Gustavo Turecki
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepre
Externí odkaz:
https://doaj.org/article/e95c158a05b749e2a3450c3b601e8593
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically reg
Externí odkaz:
https://doaj.org/article/f10fd91b52a34210bb186d3985bead84