Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

Autor: Tobias Roider, Marc A. Baertsch, Donnacha Fitzgerald, Harald Voehringer, Berit J. Brinkmann, Felix Czernilofsky, Mareike Knoll, Laura Llaó-Cid, Peter-Martin Bruch, Nora Liebers, Christian M. Schürch, Verena Passerini, Alexander Brobeil, Gunhild Mechtersheimer, Carsten Müller-Tidow, Oliver Weigert, Martina Seiffert, Garry P. Nolan, Wolfgang Huber, Sascha Dietrich

SummaryT-cell-engaging immunotherapies have improved the treatment of nodal B-cell lymphoma, but responses vary highly. Future improvements of such therapies require better understanding of the variety of lymphoma-infiltrating T-cells. We employed si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca33a72406f5099c0eccaeb7a65c0111
https://doi.org/10.1101/2022.11.04.514366

EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4 + T cells in chronic lymphocytic leukemia

Autor: Christoph Schifflers, Philipp M. Roessner, Marit Krötschel, Fabian Kilpert, Stephan Stilgenbauer, Leopold Sellner, Ekaterina Lupar, Ana Izcue, Sascha Dietrich, Marie Bordas, Ann-Christin Gaupel, Lavinia Arseni, Sebastian J. Arnold, Tobias Roider, Martina Seiffert, Laura Llaó Cid, Dolors Colomer, Peter Lichter

Publikováno v: Leukemia
Roessner, P M, Llaó Cid, L, Lupar, E, Roider, T, Bordas, M, SCHIFFLERS, C, Arseni, L, Gaupel, A-C, Kilpert, F, Krötschel, M, Arnold, S J, Sellner, L, Colomer, D, Stilgenbauer, S, Dietrich, S, Lichter, P, Izcue, A & Seiffert, M 2021, ' EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4 + T cells in chronic lymphocytic leukemia ', Leukemia, vol. 35, no. 8, pp. 2311-2324 . https://doi.org/10.1038/s41375-021-01136-1
Leukemia : normal and malignant hemopoiesis 35(8), 2311-2324 (2021). doi:10.1038/s41375-021-01136-1
Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.

Leukemia : normal and malignant hemopoiesis 35(8), 2311-2324 (2021). doi:10.1038/s41375-021-01136-1
Published by Springer Nature, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad29609cd7bbac02e747ba09a8e7c32
https://doi.org/10.1038/s41375-021-01136-1

TBET‐expressing Th1 CD4 + T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ‐TCL1 mice

Autor: Ralph Schulz, Stephan Stilgenbauer, Peter Lichter, Martina Seiffert, Laura Llaó Cid, Haniyeh Yazdanparast, Bola S. Hanna, Dolors Colomer, Philipp M. Roessner, Annika Scheffold, Selcen Öztürk

Publikováno v: British Journal of Haematology. 189:133-145

Chronic lymphocytic leukaemia (CLL) is associated with alterations in T cell number, subset distribution and function. Among these changes, an increase in CD4+ T cells was reported. CD4+ T cells are a heterogeneous population and distinct subsets hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f0c5106be35149bce8f6cc9f73adc75
https://doi.org/10.1111/bjh.16316

Phosphoinositide 3-kinase signaling in the tumor microenvironment: what do we need to consider when treating chronic lymphocytic leukemia with PI3K inhibitors?

Autor: Martina Seiffert, Laura Llaó Cid, Philipp M. Roessner, Sebastian Faehling, Ebru Aydin, Mariam Saleh

Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology

Phosphoinositide 3-kinases (PI3Ks) and their downstream proteins constitute a signaling pathway that is involved in both normal cell growth and malignant transformation of cells. Under physiological conditions, PI3K signaling regulates various cellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d9aac43b87307073a4d72066031ce

EOMES and IL-10 regulate anti-tumor activity of PD-1+CD4+T-cells in B-cell Non-Hodgkin lymphoma

Autor: Sascha Dietrich, Philipp M. Roessner, Marit Krötschel, Ekaterina Lupar, Peter Lichter, Ana Izcue, S. Stilgenbauer, Christoph Schifflers, Marie Bordas, Tobias Roider, Martina Seiffert, Laura Llaó Cid, Ann Christin Gaupel, Leopold Sellner, Fabian Kilpert, Sebastian J. Arnold

The transcription factor Eomesodermin (EOMES) promotes IL-10 production of CD4+T-cells, which has been linked to immunosuppressive and cytotoxic activities. We detected EOMES-expressing CD4+T-cells in lymph node samples of patients with chronic lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a787e7911fdea0543b4321f6737917
https://doi.org/10.1101/2020.03.09.983098