Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Laura Leys"'
Autor:
Li Zhou, Yibing Wang, Qi Wan, Fei Wu, Jeffrey Barbon, Robert Dunstan, Stephen Gauld, Mark Konrad, Laura Leys, Richard McCarthy, Marian Namovic, Christine Nelson, Gary Overmeyer, Denise Perron, Zhi Su, Leyu Wang, Susan Westmoreland, Jun Zhang, Rui Zhu, Geertruida Veldman
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Four antibodies that inhibit interleukin (IL)-23 are approved for the treatment of moderate-to-severe plaque psoriasis. Here, we present non-clinical data comparing ustekinumab, guselkumab, tildrakizumab and risankizumab with regard to thermostabilit
Externí odkaz:
https://doaj.org/article/8fcc1892569140db98948628b6cc0efe
Autor:
Geertruida Veldman, Christine Nelson, Robert Dunstan, Fei Wu, Qi Wan, Zhi Su, Marian T. Namovic, Laura Leys, Li Zhou, Richard McCarthy, Gary Overmeyer, Jun Zhang, Stephen B. Gauld, Leyu Wang, Jeffrey Barbon, Susan V. Westmoreland, Yibing Wang, Mark Konrad, Rui Zhu, Denise Perron
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Four antibodies that inhibit interleukin (IL)-23 are approved for the treatment of moderate-to-severe plaque psoriasis. Here, we present non-clinical data comparing ustekinumab, guselkumab, tildrakizumab and risankizumab with regard to thermostabilit
Autor:
K. Salte, Yibing Wang, Zhi Su, Steve McGaraughty, Joe Wetter, Laura Leys, Rebecca M. Edelmayer, P. Honore, S.E. Paulsboe, Victoria E. Scott, Stephen B. Gauld, Donna Gauvin, Isaac Weinberg, Marian Namovic
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin,
Autor:
Viktor Todorović, C. Gerstein, Arun Kannan, Li Zhou, S. Huang, S.E. Paulsboe, P. Honore, Ramkrishna Sadhukhan, Victoria E. Scott, Sheeba Mathew, Zhi Su, Leyu Wang, Marian Namovic, Michelle Viner, Rebecca M. Edelmayer, Jane Seagal, Steve McGaraughty, Lisa Rinaldi, Laura Leys, K. Salte, J. Wetter, Amanda Horowitz
Publikováno v:
Experimental Dermatology. 28:113-120
Psoriasis vulgaris (PV) results from activation of IL-23/Th17 immune pathway and is further amplified by cytokines/chemokines from skin cells. Among skin-derived pro-inflammatory cytokines, IL-36 family members are highly upregulated in PV patients a
Autor:
S. Huang, Donna Gauvin, Stephen B. Gauld, S.E. Paulsboe, P. Honore, Zheng Liu, Yibing Wang, Rebecca M. Edelmayer, Lauren Olson, K. Salte, S. McGaraughty, Laura Leys, J. Wetter
Publikováno v:
Journal of Dermatological Science. 92:45-53
Background Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it
Autor:
Arthur L. Nikkel, Marian T. Namovic, D. L. Widomski, Diana L. Donnelly-Roberts, Steve McGaraughty, Zhi Su, Laura Leys, Murali Gopalakrishnan
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 29:281-290
Background:Losartan, a blocker of the angiotensin II type I receptor, is an important part of the standard of care for diabetic nephropathy (DN). The obese ZSF-1 rats display many aspects of the clinical features of human Type II DN. The current stud
Autor:
Maya Danneels, Ruth Van Hecke, Laura Leyssens, Raymond van de Berg, Ingeborg Dhooge, Dirk Cambier, Stefan Delrue, Vincent Van Rompaey, Leen Maes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Bilateral vestibulopathy (BV) is a chronic vestibular disorder, characterized by bilaterally absent or significantly impaired vestibular function. Symptoms typically include, but are not limited to, unsteadiness and movement-induced blurred
Externí odkaz:
https://doaj.org/article/111c7211f9924785a068a24633514883
Autor:
Jill-Desiree Brederson, Michael J. Dart, Robert G. Schmidt, Steve McGaraughty, Philip R. Kym, Arthur Gomtsyan, Laura Leys, Katharine L. Chu, Richard J. Radek, Jun Xu
Publikováno v:
Journal of Neurophysiology. 118:904-916
TRPV3 is a nonselective cation channel activated by temperatures above 33°C and is reported to be localized in keratinocytes and nervous tissue. To investigate a role for TRPV3 in pain modulation, we conducted a series of in vivo electrophysiologica
Autor:
Arthur L. Nikkel, Ji Ma, L. Olson, Sujatha M. Gopalakrishnan, Kelly J. Doyle, Vivek C. Abraham, D. L. Widomski, Steve McGaraughty, Brent Putman, Murali Gopalakrishnan, Laura Leys, Chang Z. Zhu, Steve D. Pratt, Zhi Su, Chih-Hung Lee, K. Salte
Publikováno v:
European Journal of Pharmacology. 788:1-11
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizi
Autor:
Richard McCarthy, Rebecca M. Edelmayer, Maria A. Argiriadi, Didier Bressac, Craig Wallace, Michael E. Kort, Yibing Wang, Laura Leys, Eric C. Breinlinger, J. Wetter, Zhi Su, Jean-Michel Luccarini, P. Honore, K. Salte, Philippe Masson, Christian Goess, Stephen B. Gauld, Kevin P. Cusack, Donna Gauvin, S. Huang, Dominique Potin, Sébastien Jacquet, S. McGaraughty, Kelly E. Desino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 371(1)
Blockade of interleukin (IL)-23 or IL-17 with biologics is clinically validated as a treatment of psoriasis. However, the clinical impact of targeting other nodes within the IL-23/IL-17 pathway, especially with small molecules, is less defined. We re