Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Laura Lehtinen"'
Autor:
Tuomo J Meretoja, Ruixian Liu, Diether Lambrechts, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Bram Boeckx, Maija Hollmen, Rita Turpin, Pauliina M Munne, Aino Peura, Jenna H Rannikko, Gino Philips, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, July Aung, Elisa M Vuorinen, Laura Lehtinen, Minna Mutka, Panu E Kovanen, Laura Niinikoski, Andrei Goga, Jeroen Pouwels, Juha Klefström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a c
Externí odkaz:
https://doaj.org/article/cffa2828cea442bea9cecbc2dda3a9f7
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103301- (2024)
Characterized human induced pluripotent stem cell lines are important for basic research. Here, we report the establishment of three isogenic human induced pluripotent stem cell (hiPSC) lines generated from normal neonate male skin fibroblasts. Pluri
Externí odkaz:
https://doaj.org/article/1e11031e62cb4709be88cd31908ba1d9
Autor:
Elina A. Pietilä, Jordi Gonzalez-Molina, Lidia Moyano-Galceran, Sanaz Jamalzadeh, Kaiyang Zhang, Laura Lehtinen, S. Pauliina Turunen, Tomás A. Martins, Okan Gultekin, Tarja Lamminen, Katja Kaipio, Ulrika Joneborg, Johanna Hynninen, Sakari Hietanen, Seija Grénman, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Joseph W. Carlson, Kaisa Lehti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffne
Externí odkaz:
https://doaj.org/article/67c04582b2c44334b40a53907f9099c4
Autor:
Joonas Jukonen, Lidia Moyano-Galceran, Katrin Höpfner, Elina A. Pietilä, Laura Lehtinen, Kaisa Huhtinen, Erika Gucciardo, Johanna Hynninen, Sakari Hietanen, Seija Grénman, Päivi M. Ojala, Olli Carpén, Kaisa Lehti
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive processes in ways tha
Externí odkaz:
https://doaj.org/article/ecaf312fb199488291cd2a4acc2a122b
Autor:
Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén, Maria Gardberg
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look for actin regulating p
Externí odkaz:
https://doaj.org/article/98cfb8db406b442cacda4982cde9b588
Autor:
Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Laura Lehtinen, Olli Carpen, Leif C Andersson, Hanna Seppänen, Caj Haglund
Publikováno v:
Tumor Biology, Vol 40 (2018)
Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of
Externí odkaz:
https://doaj.org/article/8a7fef02c14441bfa889d04231e9c663
Autor:
Laura Lehtinen, Pia Vesterkvist, Pia Roering, Taina Korpela, Liisa Hattara, Katja Kaipio, John-Patrick Mpindi, Johanna Hynninen, Annika Auranen, Ben Davidson, Caj Haglund, Kristiina Iljin, Seija Grenman, Harri Siitari, Olli Carpen
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151590 (2016)
Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes.
Externí odkaz:
https://doaj.org/article/11d88298f8c64372a611f269ef7603e3
Autor:
Juha K. Rantala, Henrik Edgren, Laura Lehtinen, Maija Wolf, Kristine Kleivi, Hans Kristian Moen Vollan, Anna-Riina Aaltola, Petra Laasola, Sami Kilpinen, Petri Saviranta, Kristiina Iljin, Olli Kallioniemi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 11, Pp 877-888 (2010)
Aneuploidy is among the most obvious differences between normal and cancer cells. However, mechanisms contributing to development and maintenance of aneuploid cell growth are diverse and incompletely understood. Functional genomics analyses have show
Externí odkaz:
https://doaj.org/article/6f6d90d7e02a40de9e1ca47441b9ead5
Autor:
Maria Gardberg, Katja Kaipio, Laura Lehtinen, Piia Mikkonen, Vanina D Heuser, Kati Talvinen, Kristiina Iljin, Caroline Kampf, Mathias Uhlen, Reidar Grénman, Mari Koivisto, Olli Carpén
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74923 (2013)
Cancer cells can obtain their ability to invade and metastasise by undergoing epithelial-to-mesenchymal transition (EMT). Exploiting this mechanism of cellular plasticity, malignant cells can remodel their actin cytoskeleton and down-regulate protein
Externí odkaz:
https://doaj.org/article/9a9e4393398648228343bb90688dd4d8
Autor:
Rita Turpin, Ruixian Liu, Pauliina M. Munne, Aino Peura, Jenna H. Rannikko, Gino Philips, Bram Boeckx, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, Elisa M. Vuorinen, Laura Lehtinen, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Andrei Goga, Diether Lambrechts, Jeroen Pouwels, Maija Hollmén, Juha Klefström
Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a clear need f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e98c0d5b4e56701de3c89761921281
https://doi.org/10.1101/2023.05.10.539944
https://doi.org/10.1101/2023.05.10.539944