Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Laura Lagartera"'
1
Akademický článek
Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs
Autor: J. Jonathan Nué-Martinez, Marta Maturana, Laura Lagartera, Juan-Antonio Rodríguez-Gutiérrez, Roeland Boer, J. Lourdes Campos, Núria Saperas, Christophe Dardonville
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract High mobility group (HMG) proteins are intrinsically disordered nuclear non-histone chromosomal proteins that play an essential role in many biological processes by regulating the expression of numerous genes in eukaryote cells. HMGA protein
Externí odkaz: https://doaj.org/article/84c98cc369074d8b8579037c9e19b030
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2
Akademický článek
Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway
Autor: Marta Sanz-Gómez, Elnaz Aledavood, Marina Beroiz-Salaverri, Laura Lagartera, Elena Vega-Martín, Marta Gil-Ortega, Jose Cumella, Concepción Pérez, Francisco Javier Luque, Carolina Estarellas, María S. Fernández-Alfonso, Ana Castro
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Endothelial adenosine monophosphate-activated protein kinase (AMPK) plays a critical role in the regulation of vascular tone through stimulating nitric oxide (NO) release in endothelial cells. Since obesity leads to endothelial dysfunction a
Externí odkaz: https://doaj.org/article/795794dd6bc446a9849f23d01814c260
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4
Akademický článek
Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency
Autor: Myriam Sainz-Ramos, Ilia Villate-Beitia, Idoia Gallego, Nuseibah AL Qtaish, Margarita Menéndez, Laura Lagartera, Santiago Grijalvo, Ramón Eritja, Gustavo Puras, José Luis Pedraz
Publikováno v: Pharmaceutics, Vol 13, Iss 11, p 1787 (2021)
Lipid nanocarriers, such as niosomes, are considered attractive candidates for non-viral gene delivery due to their suitable biocompatibility and high versatility. In this work, we studied the influence of incorporating chloroquine in niosomes biophy
Externí odkaz: https://doaj.org/article/d14fa7f0890244419ea891e2e19ba7f5
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5
Akademický článek
Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents
Autor: Diego A. Peraza, Pilar Cercós, Pablo Miaja, Yaiza G. Merinero, Laura Lagartera, Paula G. Socuéllamos, Carolina Izquierdo García, Sara A. Sánchez, Alejandro López-Hurtado, Mercedes Martín-Martínez, Luis A. Olivos-Oré, José R. Naranjo, Antonio R. Artalejo, Marta Gutiérrez-Rodríguez, Carmen Valenzuela
Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)
Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (IA). This effect is mediated by the interaction be
Externí odkaz: https://doaj.org/article/8732c7f77a324f2fa7b4f8dc33c4a480
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6
Akademický článek
Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of Their Biological Functions
Autor: Giulia Vessella, José Antonio Vázquez, Jesús Valcárcel, Laura Lagartera, Dianélis T. Monterrey, Agatha Bastida, Eduardo García-Junceda, Emiliano Bedini, Alfonso Fernández-Mayoralas, Julia Revuelta
Publikováno v: Polymers, Vol 13, Iss 2, p 313 (2021)
Controlling chondroitin sulfates (CSs) biological functions to exploit their interesting potential biomedical applications requires a comprehensive understanding of how the specific sulfate distribution along the polysaccharide backbone can impact in
Externí odkaz: https://doaj.org/article/335fd77102074ee689a5eaebc34b590b
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7
Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease
Autor: Marta Vela, María Adelaida García-Gimeno, Ana Sanchis, José Bono-Yagüe, José Cumella, Laura Lagartera, Concepción Pérez, Eva-María Priego, Angela Campos, Pascual Sanz, Rafael P. Vázquez-Manrique, Ana Castro
Publikováno v: ACS Chem Neurosci
Digital.CSIC. Repositorio Institucional del CSIC
instname
49 páginas, 8 figuras, 2 tablas, 1 esquema. Contiene material suplementario
Aggregation of mutant huntingtin, because of an expanded polyglutamine track, underlies the cause of neurodegeneration in Huntington disease (HD). However, it remains u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5944d12417567ba5b490dcf8a56de4f
https://pubmed.ncbi.nlm.nih.gov/34962383
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8
Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency
Autor: Santiago Grijalvo, Nuseibah Al Qtaish, Ramon Eritja, Gustavo Puras, Margarita Menéndez, Ilia Villate-Beitia, Idoia Gallego, Laura Lagartera, Myriam Sainz-Ramos, José Luis Pedraz
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Pharmaceutics, Vol 13, Iss 1787, p 1787 (2021)
Pharmaceutics
Addi. Archivo Digital para la Docencia y la Investigación
Volume 13
Issue 11
Universidad de Cantabria (UC)
Lipid nanocarriers, such as niosomes, are considered attractive candidates for non-viral gene delivery due to their suitable biocompatibility and high versatility. In this work, we studied the influence of incorporating chloroquine in niosomes biophy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3715cc4f09061388ffa8ce3f815ad15b
http://hdl.handle.net/10261/253374
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9
The structure and flexibility analysis of the
Autor: Juan L, Benavente, Dritan, Siliqi, Lourdes, Infantes, Laura, Lagartera, Alberto, Mills, Federico, Gago, Noemí, Ruiz-López, Miguel A, Botella, María J, Sánchez-Barrena, Armando, Albert
Publikováno v: Life Science Alliance
Plant SYT1 transports lipids between endoplasmic reticulum and plasma membrane in response to stress. The protein flexibility and lipid-binding specificity determine SYT1 function at molecular level.
Non-vesicular lipid transfer at ER and plasma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d0ccf7f078a02446feb02a4b0eb62fb
https://pubmed.ncbi.nlm.nih.gov/34408000
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10
The structure and flexibility analysis of the Arabidopsis Synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
Autor: Noemi Ruiz-Lopez, María José Sánchez-Barrena, Dritan Siliqi, Armando Albert, Alberto Mills, Laura Lagartera, Federico Gago, Juan Luis Benavente, Lourdes Infantes, Miguel A. Botella
Publikováno v: EMBO journal (Online) 4 (2021). doi:10.26508/LSA.202101152
info:cnr-pdr/source/autori:Benavente J.L.; Siliqi D.; Infantes L.; Lagartera L.; Mills A.; Gago F.; Ruiz-Lopez N.; Botella M.A.; Sanchez-Barrena M.J.; Albert A./titolo:The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites/doi:10.26508%2FLSA.202101152/rivista:EMBO journal (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:4
Digital.CSIC. Repositorio Institucional del CSIC
instname
17 pags., 7 figs., 1 tab.
Non-vesicular lipid transfer at ER and plasma membrane (PM) contact sites (CS) is crucial for the maintenance of membrane lipid homeostasis. Extended synaptotagmins (E-Syts) play a central role in this process as they a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306f2fc8fc14ef3dfc1ca123b3d965d9
https://doi.org/10.1101/2021.04.09.438084
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