Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Autor: Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these prot

Externí odkaz: https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Autor: Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton

Publikováno v: eLife, Vol 7 (2018)

Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expr

Externí odkaz: https://doaj.org/article/00683b5eb8b74856bfb9c33328c37974

Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis

Autor: Chrissy L. Hammond, Elis Newham, Stefan Teufel, Stefan Schulte-Merker, Christine Hartmann, Rob Knight, Laura Lleras-Forero, Koichi Kawakami

Publikováno v: Lleras-Forero, L, Newham, E, Teufel, S, Kawakami, K, Hartmann, C, Hammond, C, Knight, R & Schulte-Merker, S 2020, ' Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis ', Aging, vol. 12, no. 18, pp. 18603-18621 . https://doi.org/10.18632/aging.103856
Aging (Albany NY)

Scoliosis is an abnormal bending of the body axis. Truncated vertebrae or a debilitated ability to control the musculature in the back can cause this condition, but in most cases the causative reason for scoliosis is unknown (idiopathic). Using mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec1d595ceafc17d87b7315ea577b0c1
https://doi.org/10.18632/aging.103856

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Autor: Cameron Wyatt, Stefan Schulte-Merker, Witold Rybski, E. Elizabeth Patton, Nicholas D. Hastie, Juan Carlos Lopez-Baez, Zhiqiang Zeng, Laura Lleras-Forero, Hannah Brunsdon

Publikováno v: Zeng, Z, Lopez-Baez, J C, LLeras Forero, L, Brunsdon, H, Wyatt, C, Rybski, W, Hastie, N, Schulte-Merker, S & Patton, E 2018, ' Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae ', vol. 8, no. 23, pp. e3100 . https://doi.org/10.21769/BioProtoc.3100
Bio-protocol
BIO-PROTOCOL

Zebrafish have become an increasingly important model organism in the field of wound healing and regenerative medicine, due to their high regenerative capacity coupled with high-resolution imaging in living animals. In a recent study, we described mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d105f9b2c6ef56665b443c6fd805d879
https://www.pure.ed.ac.uk/ws/files/76967099/Notochord_Injury_Assays_that_Stimulate_Transcriptional_Responses_in_Zebrafish_Larvae.pdf

Author response: Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

Autor: Andrew C. Oates, Stefan Schulte-Merker, Laura Lleras Forero, Maaike Vanbergen, Rachna Narayanan, Ive Logister, Leonie F. A. Huitema, Guillaume Valentin, Josi Peterson-Maduro, Luis G. Morelli, Alexander Apschner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80eaf9401ca236caff955df34864d198
https://doi.org/10.7554/elife.33843.043