Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Laura L. Wootton"'
Autor:
Paul F. Worth, Venkataramanan Srinivasan, Anna Smith, James I. Last, Laura L. Wootton, Paul M. Biggs, Nicholas P. Davies, Ellen F. Carney, Philip J. Byrd, A. Malcolm R. Taylor
Publikováno v:
Movement Disorders. 28:524-528
Background The major clinical feature of ataxia telangiectasia (A-T) is severe progressive neurodegeneration with onset in infancy. This classical A-T phenotype is caused by biallelic null mutations in the ATM gene, leading to the absence of ATM prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ca3996a0f7545e50ca9457d6604f7d
https://doi.org/10.1002/mds.25236
https://doi.org/10.1002/mds.25236
Autor:
Fawaz Al-Mousa, Christopher J. Kirk, Pei F. Lai, Francesco Michelangeli, Laura L. Wootton, Oluseye A. Ogunbayo, R.M. Harris, Rosemary H. Waring
Publikováno v:
Chemico-Biological Interactions. 176:220-226
Alkylphenols such as nonylphenol are pollutants that are widely dispersed within our environment. They bio-accumulate within man, with levels in the μM concentration range reported in human tissues. These chemicals act as endocrine disruptors, havin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6110f011b81acda34602e1954cf238c9
https://doi.org/10.1016/j.cbi.2008.08.005
https://doi.org/10.1016/j.cbi.2008.08.005
Publikováno v:
Journal of Biological Chemistry. 281:6970-6976
Three isoforms of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) are known to exist in mammalian cells. This study investigated the effects of thapsigargin and a variety of commonly used hydrophobic inhibitors on these SERCA isoforms (i.e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b5692a432b8b39fa91577b6b0dbd80
https://doi.org/10.1074/jbc.m510978200
https://doi.org/10.1074/jbc.m510978200
Publikováno v:
Biochemical Journal. 366:255-263
The pharmacology of macrocyclic lactones is varied, with many beneficial effects in treating disease processes. FK-506, rapamycin and ascomycin have been utilized as immunosuppressant agents. Ivermectin is typically used to treat parasitic worm infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da4ca8f5f6ac6bf05befd8b6f5d2c01
https://doi.org/10.1042/bj20020431
https://doi.org/10.1042/bj20020431
Autor:
Claire V. Harper, Stephen J. Publicover, Laura L. Wootton, Christopher L.R. Barratt, Francesco Michelangeli, Linda Lefièvre
Publikováno v:
Journal of cell science. 118(Pt 8)
The sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase (SERCA) inhibitors thapsigargin (0.1-1 microM) and cyclopiazonic acid (10 microM), failed to affect resting [Ca(2+)] in human spermatozoa. Slow progesterone-induced [Ca(2+ i)](i) oscillations in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471f258cfc1a87be25ab8d9338d82e4d
https://pubmed.ncbi.nlm.nih.gov/15811949
https://pubmed.ncbi.nlm.nih.gov/15811949
Publikováno v:
Current opinion in cell biology. 17(2)
The endoplasmic reticulum is not the only major agonist-releasable Ca2+ store within cells; it is now clear that virtually all organelles so far studied have the ability to act as mobilizable Ca2+ stores. From recent findings with regard to Ca2+ tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070f6d20b525aaf7851a6a38ecd64dcd
https://pubmed.ncbi.nlm.nih.gov/15780589
https://pubmed.ncbi.nlm.nih.gov/15780589
Publikováno v:
Biochimica et biophysica acta. 1664(2)
The distribution of the secretory pathway Ca2+-ATPase (SPCA1) was investigated at both the mRNA and protein level in a variety of tissues. The mRNA and the protein for SPCA1 were relatively abundant in rat brain, testis and testicular derived cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9505868c84f4727b90e270505ecebd4d
https://pubmed.ncbi.nlm.nih.gov/15328051
https://pubmed.ncbi.nlm.nih.gov/15328051
Autor:
Rita E. Godfrey, Laura L. Wootton, Jonathan G. Bilmen, Oliver S. Smart, Francesco Michelangeli
Publikováno v:
European journal of biochemistry. 269(15)
2-Aminoethoxydiphenyl Borate (2-APB) has been extensively used recently as a membrane permeable modulator of inositol-1,4,5-trisphosphate-sensitive Ca2+ channels and store-operated Ca2+ entry. Here, we report that 2-APB is also an inhibitor of sarco/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e23480e945e6579c2b3fae0c0c3e582
https://pubmed.ncbi.nlm.nih.gov/12153564
https://pubmed.ncbi.nlm.nih.gov/12153564
Autor:
Harper C; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Wootton L, Michelangeli F, Lefièvre L, Barratt C, Publicover S
Publikováno v:
Journal of cell science [J Cell Sci] 2005 Apr 15; Vol. 118 (Pt 8), pp. 1673-85.