Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Laura L. Vollmer"'
Autor:
Jordan Sanders, Michael Castiglione, Tongying Shun, Laura L. Vollmer, Mark E. Schurdak, Andreas Vogt, Anthony Schwacha
Publikováno v:
SLAS Discovery, Vol 27, Iss 4, Pp 229-241 (2022)
Mcm2-7 is the catalytic core of the eukaryotic replicative helicase, which together with CDC45 and the GINS complex unwind parental DNA to generate templates for DNA polymerase. Being a highly regulated and complex enzyme that operates via an incompl
Externí odkaz:
https://doaj.org/article/dace82500f2d426da52ccee7a1d3e830
Autor:
Manush Saydmohammed, Laura L. Vollmer, Ezenwa O. Onuoha, Taber S. Maskrey, Gregory Gibson, Simon C. Watkins, Peter Wipf, Andreas Vogt, Michael Tsang
Publikováno v:
Molecules, Vol 23, Iss 7, p 1691 (2018)
Zebrafish is the preferred vertebrate model for high throughput chemical screens to discover modulators of complex biological pathways. We adapted a transgenic zebrafish line, Tg(dusp6:EGFP), which reports on fibroblast growth factor (Fgf)/Ras/Mapk a
Externí odkaz:
https://doaj.org/article/0bdae4bf71594917881c66f98bc5d992
Autor:
Andreas Vogt, Billy W. Day, Dennis P. Curran, Neil A. Hukriede, John S. Lazo, Celeste E. Reese, Raghavan Balachandran, Hikmat N. Daghestani, Wei Zhu, Daniel P. Camarco, Maria Jiménez, Laura L. Vollmer
The natural product (−)-dictyostatin is a microtubule-stabilizing agent that potently inhibits the growth of human cancer cells, including paclitaxel-resistant clones. Extensive structure–activity relationship studies have revealed several region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecdf80d5efb235382c6a7baaca49a0a2
https://doi.org/10.1158/1535-7163.c.6535479
https://doi.org/10.1158/1535-7163.c.6535479
Autor:
Andreas Vogt, Billy W. Day, Dennis P. Curran, Neil A. Hukriede, John S. Lazo, Celeste E. Reese, Raghavan Balachandran, Hikmat N. Daghestani, Wei Zhu, Daniel P. Camarco, Maria Jiménez, Laura L. Vollmer
Supplementary Tables 1-2,Characterization Data & References from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fec54cded103cf86b1a690df8d0627
https://doi.org/10.1158/1535-7163.22497030.v1
https://doi.org/10.1158/1535-7163.22497030.v1
Autor:
Andreas Vogt, Billy W. Day, Dennis P. Curran, Neil A. Hukriede, John S. Lazo, Celeste E. Reese, Raghavan Balachandran, Hikmat N. Daghestani, Wei Zhu, Daniel P. Camarco, Maria Jiménez, Laura L. Vollmer
NMR Spectra from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45de1697f469204b948471244ec8f90e
https://doi.org/10.1158/1535-7163.22497033
https://doi.org/10.1158/1535-7163.22497033
Autor:
Michael J. Palladino, Stacy L. Hrizo, Tracey D. Myers, E. Michael Meyer, Samantha L. Eicher, Laura L. Vollmer, Andreas Vogt
Publikováno v:
SLAS Discov
Triose phosphate isomerase deficiency (TPI Df) is an untreatable, childhood-onset glycolytic enzymopathy. Patients typically present with frequent infections, anemia, and muscle weakness that quickly progresses with severe neuromusclar dysfunction re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78b9d7cf55833eb02dbe04ac409cf5b
https://doi.org/10.1177/24725552211018198
https://doi.org/10.1177/24725552211018198
Autor:
Marion E Joy, Laura L Vollmer, Keren Hulkower, Andrew M Stern, Cameron K Peterson, R C Dutch Boltz, Partha Roy, Andreas Vogt
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88350 (2014)
Profilin-1 (Pfn-1) is a ubiquitously expressed actin-binding protein that is essential for normal cell proliferation and migration. In breast cancer and several other adenocarcinomas, Pfn-1 expression is downregulated when compared to normal tissues.
Externí odkaz:
https://doaj.org/article/430c2c842c824c11bc88aa5d6d9ab585
Autor:
William P. Schiemann, Marion Joy, Chang Jiang, Sujoy Ghosh, Zhijie Ding, Donna B. Stolz, Andreas Vogt, David Gau, Michael Oddo, Partha Roy, Laura L. Vollmer, Souvik Chakraborty
Publikováno v:
British journal of cancer, vol. 119, no. 9, pp. 1106-1117
British Journal of Cancer
British Journal of Cancer
Background Adhesion-mediated activation of FAK/ERK signalling pathway, enabled by the formation of filopodial protrusions (FLP), has been shown to be an important event for triggering of dormancy-to-proliferation switch and metastatic outgrowth of br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0b9d72c02267448bb7b8ae18a5dd4e
https://serval.unil.ch/notice/serval:BIB_B955C50F0041
https://serval.unil.ch/notice/serval:BIB_B955C50F0041
Autor:
Andreas Vogt, Vasiliy N. Korotchenko, Keren I. Hulkower, Lawrence Vernetti, Billy W. Day, Laura L. Vollmer, Michael T. Lotze, Michael Tsang, Christof Kaltenmeier, Keanu Davis, Lindsay Caprio
Dual specificity mitogen-activated protein kinase (MAPK) phosphatases [dual specificity phosphatase/MAP kinase phosphatase (DUSP-MKP)] have been hypothesized to maintain cancer cell survival by buffering excessive MAPK signaling caused by upstream ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6c4e1ed744ce196fe3bb393a8c6d7a
https://europepmc.org/articles/PMC5363763/
https://europepmc.org/articles/PMC5363763/
Publikováno v:
SLAS Discovery. 19:556-565
Nef is a human immunodeficiency virus 1 (HIV-1) accessory factor essential for viral pathogenesis and AIDS progression. Many Nef functions require dimerization, and small molecules that block Nef dimerization may represent antiretroviral drug leads.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d33fc10fa8938dd8898c81e45ced94
https://doi.org/10.1177/1087057113513640
https://doi.org/10.1177/1087057113513640