Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura L. Pontano"'
Autor:
J. Alan Diehl, Laura L. Pontano
Publikováno v:
Cell Cycle. 8:824-827
Ubiquitin mediated degradation of cyclin D1 following the G(1)/S transition counters its mitogen-dependent accumulation during G(1) phase of the cell cycle. Although the cellular machinery responsible for this process has been identified, how this re
Autor:
Priya Aggarwal, Craig H. Bassing, J. Alan Diehl, Olena Barbash, Laura L. Pontano, Eric J. Brown
Publikováno v:
Molecular and Cellular Biology. 28:7245-7258
While mitogenic induction of cyclin D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation and prevents aberrant proliferation. Because the failure to degrade cyclin D1 during S-phase triggers DNA rereplica
Autor:
Priya Aggarwal, Douglas I. Lin, Craig H. Bassing, Mariusz A. Wasik, Andrew B. Gladden, Matthew D. Lessie, Laura L. Pontano, Beth Nuskey, J. Alan Diehl, Andres J. Klein-Szanto, Ami Goradia, Anil K. Rustgi
Publikováno v:
Genes & Development. 21:2908-2922
Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to
Publikováno v:
Oncogene
Protein ubiquitylation is a complex enzymatic process that results in the covalent attachment of ubiquitin, through Gly-76 of ubiquitin, to an varepsilonNH2 group of an internal lysine residue in a given substrate. Although E3 ligases frequently use
Autor:
Eric J. Brown, Avinash Bhandoola, Marielena Velez, Valerie P. Zediak, Carolina Pinzon-Guzman, Yaroslava Ruzankina, Laura L. Pontano, Tony Ong, George Cotsarelis, Amma Asare
Publikováno v:
Cell stem cell. 1(1)
SummaryDevelopmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (S
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
J. Alan Diehl, Laura L. Pontano
Publikováno v:
Cell Division, Vol 3, Iss 1, p 12 (2008)
Cell Division
Cell Division
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286) phosp
Autor:
Li J; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Van Vranken JG; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Pontano Vaites L; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Schweppe DK; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Huttlin EL; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Etienne C; Thermo Fisher Scientific, Rockford, IL, USA., Nandhikonda P; Thermo Fisher Scientific, Rockford, IL, USA., Viner R; Thermo Fisher Scientific, San Jose, CA, USA., Robitaille AM; Thermo Fisher Scientific, San Jose, CA, USA., Thompson AH; Proteome Sciences, London, UK., Kuhn K; Proteome Sciences, London, UK., Pike I; Proteome Sciences, London, UK., Bomgarden RD; Thermo Fisher Scientific, Rockford, IL, USA., Rogers JC; Thermo Fisher Scientific, Rockford, IL, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Steven_Gygi@hms.harvard.edu., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Joao_Paulo@hms.harvard.edu.
Publikováno v:
Nature methods [Nat Methods] 2020 Apr; Vol. 17 (4), pp. 399-404. Date of Electronic Publication: 2020 Mar 16.
Autor:
Pontano Vaites L, Harper JW
Publikováno v:
Nature [Nature] 2018 Mar 22; Vol. 555 (7697), pp. 449-451.
Autor:
Huttlin EL; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Bruckner RJ; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Cannon JR; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Ting L; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Baltier K; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Colby G; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Gebreab F; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Gygi MP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Parzen H; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Szpyt J; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Tam S; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Zarraga G; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Pontano-Vaites L; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Swarup S; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., White AE; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Schweppe DK; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Rad R; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Erickson BK; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Obar RA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.; Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA., Guruharsha KG; Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA., Li K; Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA., Artavanis-Tsakonas S; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.; Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Harper JW; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Publikováno v:
Nature [Nature] 2017 May 25; Vol. 545 (7655), pp. 505-509. Date of Electronic Publication: 2017 May 17.