Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Laura L. Perissinotti"'
Autor:
Laura L. Perissinotti, Pablo M. De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C. Lee, Colleen E. Clancy, Henry J. Duff, Sergei Y. Noskov
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in h
Externí odkaz:
https://doaj.org/article/55a6b48ac7ca4144877062bf442031c9
Autor:
Jiqing Guo, Serdar Durdagi, Mohamed Changalov, Laura L Perissinotti, Jason M Hargreaves, Thomas G Back, Sergei Y Noskov, Henry J Duff
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e105553 (2014)
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent pharmacologic blockade of K+, Ca2+ and Na+ currents. Many drugs inadvertently block hERG1 leading to an acquired form of the Long QT
Externí odkaz:
https://doaj.org/article/f7a4836d5fd74443b08ab39ad724be7c
Autor:
Yibo Wang, Sergei Y. Noskov, Junko Kurokawa, Colleen E. Clancy, Laura L. Perissinotti, Kevin R. DeMarco, Mao Tsuen Jeng, Robert D. Harvey, Fernando López-Redondo, Pei Chi Yang, Igor Vorobyov
Publikováno v:
The Journal of Physiology. 595:4695-4723
Author(s): Yang, Pei-Chi; Perissinotti, Laura L; Lopez-Redondo, Fernando; Wang, Yibo; DeMarco, Kevin R; Jeng, Mao-Tsuen; Vorobyov, Igor; Harvey, Robert D; Kurokawa, Junko; Noskov, Sergei Y; Clancy, Colleen E | Abstract: KEY POINTS:This study represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8fcadea136d2d7cf0a037dae9e3d05d
https://doi.org/10.1113/jp273142
https://doi.org/10.1113/jp273142
Publikováno v:
Biophysical Journal. 112:1645-1653
Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular calcium release channels essential for many cellular processes ranging from muscle contraction to learning and memory. Little is known of the atomistic details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc33e46074372e215e3db5a6ac54012
https://doi.org/10.1016/j.bpj.2017.03.014
https://doi.org/10.1016/j.bpj.2017.03.014
Autor:
German L. Perlovich, Laura L. Perissinotti, James Paul Lees-Miller, Meruyert Kudaibergenova, Marina V. Ol’khovich, Sergei Y. Noskov, Jiqing Guo, Angelica V. Sharapova, Daniel A. Muruve, Henry J. Duff, Brenda Gerull
Publikováno v:
Mol Pharmacol
Abnormal cardiac electrical activity is a common side effect caused by unintended block of the promiscuous drug target human ether-à-go-go-related gene (hERG1), the pore-forming domain of the delayed rectifier K(+) channel in the heart. hERG1 block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9541e3deb855479138090ca2c4d1bcb3
https://pubmed.ncbi.nlm.nih.gov/31182542
https://pubmed.ncbi.nlm.nih.gov/31182542
Publikováno v:
Neuroscience letters. 700
Human-ether-a-go-go-related channel (hERG) is a voltage gated potassium channel (Kv11.1) abundantly expressed in heart and brain tissues. In addition to playing an important role in mediation of repolarizing K+ currents (IKr) in Action Potential (AP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e00bbeaf242383744cf5e0eed78291
https://pubmed.ncbi.nlm.nih.gov/29758301
https://pubmed.ncbi.nlm.nih.gov/29758301
Autor:
Colleen E. Clancy, Henry J. Duff, Pablo M. De Biase, Sergei Y. Noskov, Pei Chi Yang, Laura L. Perissinotti, Miranda C. Lee, Jiqing Guo
Publikováno v:
Frontiers in physiology, vol 9, iss APR
Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)
Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f506cedeb784c98a762eb2ac4f3d6a8
https://escholarship.org/uc/item/5qb76820
https://escholarship.org/uc/item/5qb76820
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1865(11 Pt)
The rapid development of experimental and computational techniques has changed fundamentally our understanding of cellular-membrane transport. The advent of powerful computers and refined force-fields for proteins, ions, and lipids has expanded the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40d206e025620f5a507a3ccf47c267b
https://pubmed.ncbi.nlm.nih.gov/28847523
https://pubmed.ncbi.nlm.nih.gov/28847523
Autor:
Pei-Chi, Yang, Laura L, Perissinotti, Fernando, López-Redondo, Yibo, Wang, Kevin R, DeMarco, Mao-Tsuen, Jeng, Igor, Vorobyov, Robert D, Harvey, Junko, Kurokawa, Sergei Y, Noskov, Colleen E, Clancy
Publikováno v:
The Journal of Physiology
Key points This study represents a first step toward predicting mechanisms of sex‐based arrhythmias that may lead to important developments in risk stratification and may inform future drug design and screening.We undertook simulations to reveal th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7873f18091d835457d3b6da01e24b73
https://pubmed.ncbi.nlm.nih.gov/28516454
https://pubmed.ncbi.nlm.nih.gov/28516454
Autor:
Laura L. Perissinotti, Amnon Kohen, Scott A. Lesley, Salah Moghram, Eric M. Koehn, Arjun Prabhakar, Irimpan I. Mathews
Publikováno v:
Proceedings of the National Academy of Sciences. 109:15722-15727
The DNA nucleotide thymidylate is synthesized by the enzyme thymidylate synthase, which catalyzes the reductive methylation of deoxyuridylate using the cofactor methylene-tetrahydrofolate (CH 2 H 4 folate). Most organisms, including humans, rely on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc84f8d6ff55793549b21be83576f41d
https://doi.org/10.1073/pnas.1206077109
https://doi.org/10.1073/pnas.1206077109