Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Laura L. Pashko"'
Autor:
Kenneth I. Strauss, Laura L. Pashko, Russell W. Cole, Arthur G. Schwartz, Raj K. Narayan, Amir S. Malik, Woodrow W. Wendling
Publikováno v:
Journal of Neurotrauma. 20:463-476
The purpose of this study was to investigate the efficacy of a novel steroid, fluasterone (DHEF, a dehydroepiandrosterone (DHEA) analog), at improving functional recovery in a rat model of traumatic brain injury (TBI). The lateral cortical impact mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d88ee8fe3bd6d504f3c5b099cb8714
https://doi.org/10.1089/089771503765355531
https://doi.org/10.1089/089771503765355531
Autor:
Arthur G. Schwartz, Laura L. Pashko
Publikováno v:
Military Medicine. 167:60-63
The adrenal steroid dehydroepiandrosterone (DHEA) produces cancer-preventive, antiatherosclerotic, antidiabetic, immunomodulating, and anti-inflammatory effects in laboratory animals. The clinical use of DHEA is limited by its androgenicity. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa41070881cc7f2c86e219ecf203a9c
https://doi.org/10.1093/milmed/167.suppl_1.60
https://doi.org/10.1093/milmed/167.suppl_1.60
Autor:
Laura L. Pashko, Arthur G. Schwartz
Publikováno v:
Diabetes Technology & Therapeutics. 3:221-224
221 ALTHOUGH DEHYDROEPIANDROSTERONE (DHEA) was first isolated from human urine by Butenandt and Tscherining in 1934, the biological significance of this steroid remains a mystery.1 In the first years of life, the human adrenal produces little DHEA un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::932e61eba2c90fcfd8b9f16750d06dda
https://doi.org/10.1089/152091501300209589
https://doi.org/10.1089/152091501300209589
Autor:
Arthur G. Schwartz, Laura L. Pashko
Publikováno v:
Carcinogenesis. 17:209-212
Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2996aa3341ec39fdc7fcc8418d4e38
https://doi.org/10.1093/carcin/17.2.209
https://doi.org/10.1093/carcin/17.2.209
Autor:
Arthur G. Schwartz, Laura L. Pashko
Publikováno v:
Annals of the New York Academy of Sciences. 774:180-186
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b420fdb9493df9bb02145b1b7100efe9
https://doi.org/10.1111/j.1749-6632.1995.tb17381.x
https://doi.org/10.1111/j.1749-6632.1995.tb17381.x
Autor:
Laura L. Pashko, Arthur G. Schwartz
Publikováno v:
Journal of Cellular Biochemistry. 59:210-217
There is increasing evidence that the adrenocortical steroid, dehydroepiandrosterone (DHEA), is an important mammalian hormone. Administration of DHEA to laboratory mice and rats inhibits development of experimental tumors of the breast, lung, colon,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604fb748ed3695ac9b077cf47ce139ac
https://doi.org/10.1002/jcb.240590826
https://doi.org/10.1002/jcb.240590826
Publikováno v:
Carcinogenesis. 12:2189-2192
The work of ourselves and others has demonstrated that dehydroepiandrosterone (DHEA) dispalys a broad spectrum of cancer preventive action in laboratory rodents, with little toxicity. In the two-stage skin tumorigenesis model in mice, topical applica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4703a9403fb57082c0fc8497c97a8d
https://doi.org/10.1093/carcin/12.11.2189
https://doi.org/10.1093/carcin/12.11.2189
Publikováno v:
Diabetes. 57(2)
OBJECTIVE—Obesity is associated with insulin resistance, hyperinsulinemia, elevated plasma free fatty acid (FFA), and increased risk for atherosclerotic vascular disease (ASVD). A part of this increased risk may be due to enhanced activation of mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fcf2918a4094b8aa7ec34982f30a08
https://pubmed.ncbi.nlm.nih.gov/18025411
https://pubmed.ncbi.nlm.nih.gov/18025411
Autor:
Laura L. Pashko, Arthur G. Schwartz
Publikováno v:
Cancer Chemoprevention ISBN: 9781617373428
Dehydroepiandrosterone (DHEA) is a major adrenal cortical steroid in humans (1, 2). The plasma levels of DHEA and its sulfated ester rise early in life, reaching a maximum in the second decade, and decline thereafter throughout adult life, whereas co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aafd7a425c1e5e412812264cdc00217
https://doi.org/10.1007/978-1-59259-767-3_19
https://doi.org/10.1007/978-1-59259-767-3_19
Autor:
Laura L. Pashko, Arthur G. Schwartz
Publikováno v:
Ageing research reviews. 3(2)
Dehydroepiandrosterone (DHEA) is an abundantly produced adrenal steroid whose biological role has never been clarified. DHEA is a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH) and as a consequence lowers NADPH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e5761316db5bfa4791fb00429b9b75
https://pubmed.ncbi.nlm.nih.gov/15177053
https://pubmed.ncbi.nlm.nih.gov/15177053