A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.

Autor: Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon

Publikováno v: PLoS Genetics, Vol 4, Iss 2, p e24 (2008)

In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy, the large-scale recycling of cytoplasmic macromolecules and organ

Externí odkaz: https://doaj.org/article/a6fa573a97ca435d8cee88cb9e1048da

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Autor: Laura L. Mitic, Joel H. Kramer, Laura Jastrzab, Matthew A. Lalli, Brianne M. Bettcher, Matthew Wynn, Bruce L. Miller, Ryan Fitch, Kenneth S. Kosik, Jonathan Elofson, Zachary A. Miller, Gil D. Rabinovici, Aimee W. Kao

Publikováno v: Bettcher, BM; Fitch, R; Wynn, MJ; Lalli, MA; Elofson, J; Jastrzab, L; et al.(2016). MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.. Alzheimer's & dementia (Amsterdam, Netherlands), 3, 91-97. doi: 10.1016/j.dadm.2016.05.004. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2cs922xz
Alzheimer's & dementia (Amsterdam, Netherlands), vol 3, iss 1
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 3, Iss 1, Pp 91-97 (2016)

Introduction MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9800a7017481d50ea5a47fbcdfc33f20

Prosaposin is a regulator of progranulin levels and oligomerization

Autor: Dennis W. Dickson, Laura L. Mitic, Alexandra M. Nicholson, Guojun Bu, Sharon P. Fowler, Basar Cenik, Gonçalo R. Abecasis, Joachim Herz, Goo Jun, Neill R. Graff-Radford, Shawn M. Ferguson, Ying Sun, Alisa K. Manning, Venette Inskeep, Thomas D. Dyer, Rosa Rademakers, Ni Cole A. Finch, Aleksandra Wojtas, Anna Karydas, Ravindranath Duggirala, John Blangero, Haaris A. Zahir, Juan M. Peralta, Laura Almasy, Christian Fuchsberger, Cyril Pottier, Donna M. Lehman, Ronald C. Petersen, Gang Yu, Andrew R. Wood, Tanya M. Teslovich, Ralph B. Perkerson, Marka van Blitterswijk, Julia E. Crook, Satish Kumar, Bruce L. Miller, Marcio Almeida, Timothy M. Frayling, Sergio Rotondo, Joanne E. Curran

Publikováno v: Nature communications, vol 7, iss 1
Nature Communications
Nicholson, AM; Finch, NA; Almeida, M; Perkerson, RB; van Blitterswijk, M; Wojtas, A; et al.(2016). Prosaposin is a regulator of progranulin levels and oligomerization. NATURE COMMUNICATIONS, 7. doi: 10.1038/ncomms11992. UCSF: Retrieved from: http://www.escholarship.org/uc/item/0jj050pt
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature communications

Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dc6dc16d722c21843a3b823735cc85
https://escholarship.org/uc/item/0jj050pt

Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut

Autor: James M. Anderson, Christoph Rahner, Laura L. Mitic

Publikováno v: Gastroenterology. 120:411-422

Background & Aims: Paracellular transport varies widely among epithelia of the gastrointestinal tract. We determined whether members of the claudin family of tight junction proteins are differentially expressed consistent with a potential role in cre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fdb347a3e2ca45ed01a0bdf07c1039
https://doi.org/10.1053/gast.2001.21736

CaCo-2 Cells Treated with Clostridium perfringensEnterotoxin Form Multiple Large Complex Species, One of Which Contains the Tight Junction Protein Occludin

Autor: Laura L. Mitic, Bruce A. McClane, Usha Singh, Christina M. Van Itallie, James M. Anderson

Publikováno v: Journal of Biological Chemistry. 275:18407-18417

The previous model for the action of Clostridium perfringens enterotoxin (CPE) proposed that (i) CPE binds to host cell receptor(s), forming a small ( approximately 90 kDa) complex, (ii) the small complex interacts with other eucaryotic protein(s), f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d13deb2cb4bb50112ef8b26fc9b4394
https://doi.org/10.1074/jbc.m001530200