Glucose-Sensing in the Reward System

Autor: Laura L. Koekkoek, Joram D. Mul, Susanne E. la Fleur

Publikováno v: Frontiers in Neuroscience, Vol 11 (2017)

Glucose-sensing neurons are neurons that alter their activity in response to changes in extracellular glucose. These neurons, which are an important mechanism the brain uses to monitor changes in glycaemia, are present in the hypothalamus, where they

Externí odkaz: https://doaj.org/article/60d6464376304bdbad18f5494a9c1758

Dopamine D1 receptor signalling in the lateral shell of the nucleus accumbens controls dietary fat intake in male rats

Autor: Tess Kool, Charlene Diepenbroek, Joram D. Mul, Michel Barrot, Susanne E la Fleur, Anil Joshi, Leslie Eggels, Laura L Koekkoek, Andries Kalsbeek

Publikováno v: Appetite, 167:105597. Academic Press Inc.
Appetite
Appetite, Elsevier, 2021, 167, pp.105597. ⟨10.1016/j.appet.2021.105597⟩
Appetite, 167. Academic Press

Central dopamine signaling regulates reward-related aspects of feeding behavior, and during diet-induced obesity dopamine receptor signaling is altered. Yet, the influence of dopamine signaling on the consumption of specific dietary components remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8367a1ad3c9690ed367031ee4ff49758
https://dare.uva.nl/personal/pure/en/publications/dopamine-d1-receptor-signalling-in-the-lateral-shell-of-the-nucleus-accumbens-controls-dietary-fat-intake-in-male-rats(b79ed498-2e1f-4ebb-9064-885a8e146e03).html

Disruption of lateral hypothalamic calorie detection by a free choice high fat diet

Autor: Ian M. Linville, Mireille J. Serlie, Margo Slomp, Serge Luquet, Laura L. Koekkoek, Susanne E. la Fleur, Julien Castel, Michael E. Mutersbaugh

Publikováno v: FASEB Journal
FASEB Journal, 2021, 35 (9), ⟨10.1096/fj.202100762r⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (9), ⟨10.1096/fj.202100762r⟩
FASEB journal, 35(9):e21804. FASEB

International audience; During the last few decades, the consumption of low-calorie sweeteners, as a substitute for caloric sweeteners, has sharply increased. Although research shows that caloric versus low-calorie sweeteners can have differential ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e825d8086718a9371eb1b322d00e037a
https://hal.science/hal-03372053

The Role of the Gut Microbiota in the Gut-Brain Axis in Obesity: Mechanisms and Future Implications

Autor: Laura L. Koekkoek, Jamie van Son, Mireille J. Serlie, Max Nieuwdorp, Susanne E. la Fleur

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2993, p 2993 (2021)

Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a global epidemic that affects individual health and strains th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c45c2916e2c74cb7922373ef6e76a
https://pubmed.ncbi.nlm.nih.gov/33804250

Synergistic Effect of Feeding Time and Diet on Hepatic Steatosis and Gene Expression in Male Wistar Rats

Autor: Unga A. Unmehopa, Eric Fliers, Joanne Verheij, Johanneke E. Oosterman, Ewout Foppen, Laura L. Koekkoek, Andries Kalsbeek, Susanne E. la Fleur, Leslie Eggels

Publikováno v: Obesity, 28(Suppl. 1), S81-S92. Wiley-Blackwell
Obesity (Silver Spring, Md.), 28(S1), S81-S92. North American Association for the Study of Obesity
Obesity (Silver Spring, Md.)

Objective: Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. Diet composition can also affect clock gene expression. This study assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b4b2f6d5860c09571aa1c242636219
https://pure.knaw.nl/portal/en/publications/0d11148d-204a-41e0-9c50-0ee6913cc26a