Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Laura L. Ekblad"'
Autor:
Claudia Tato-Fernández, Laura L. Ekblad, Elina Pietilä, Virva Saunavaara, Semi Helin, Riitta Parkkola, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne, Anniina Snellman
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106439- (2024)
Except for aging, carrying the APOE ε4 allele (APOE4) is the most important risk factor for sporadic Alzheimer's disease. APOE4 carriers may have reduced capacity to recycle lipids, resulting in white matter microstructural abnormalities. In this st
Externí odkaz:
https://doaj.org/article/74de84ee23144774a5173a4f384899cd
Autor:
Elina Pietilä, Anniina Snellman, Jouni Tuisku, Semi Helin, Matti Viitanen, Antti Jula, Juha O. Rinne, Laura L. Ekblad
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106385- (2024)
We studied if midlife insulin resistance (IR) and APOE genotype would predict brain beta-amyloid (Aβ) accumulation and Aβ change in late-life in 5-year follow-up [11C]PIB-PET study. 43 dementia-free participants were scanned twice with [11C]PIB-PET
Externí odkaz:
https://doaj.org/article/6e5db428506544d58bbdf60d855047ba
Autor:
Anniina Snellman, Laura L. Ekblad, Jouni Tuisku, Mikko Koivumäki, Nicholas J. Ashton, Juan Lantero-Rodriguez, Thomas K. Karikari, Semi Helin, Marco Bucci, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Neuroinflammation, characterized by increased reactivity of microglia and astrocytes in the brain, is known to be present at various stages of the Alzheimer’s disease (AD) continuum. However, its presence and relationship with a
Externí odkaz:
https://doaj.org/article/c691f60e95844b5ab184a43042c094dc
Autor:
Anniina Snellman, Laura L. Ekblad, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero-Rodriguez, Elina Pietilä, Mikko Koivumäki, Semi Helin, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106175- (2023)
Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels and their association with regional β-amyloid (Aβ) pathology and c
Externí odkaz:
https://doaj.org/article/fe2337a6574743a495a762ce5b91b86e
Autor:
Anniina Snellman, Laura L. Ekblad, Mikko Koivumäki, Noora Lindgrén, Jouni Tuisku, Merja Perälä, Lila Kallio, Riina Lehtonen, Virva Saunavaara, Jani Saunavaara, Vesa Oikonen, Richard Aarnio, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundDetailed characterization of early pathophysiological changes in preclinical Alzheimer's disease (AD) is necessary to enable development of correctly targeted and timed disease-modifying treatments. ASIC-E4 study (“Beta-Amyloid, Synaptic
Externí odkaz:
https://doaj.org/article/1fb4379f44584a3c8dca82e7d8965833
Publikováno v:
Journal of Alzheimer's Disease. 92:349-359
Background: Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2
Publikováno v:
Alzheimer´s Disease Neuroimaging Initiative 2021, ' Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42 ', Neurobiology of Aging, vol. 107, pp. 42-52 . https://doi.org/10.1016/j.neurobiolaging.2021.07.003
Neurobiology of Aging, 107, 42-52. Elsevier Science
Neurobiology of Aging, 107, 42-52. Elsevier Inc.
Neurobiology of Aging, 107, 42-52. Elsevier Science
Neurobiology of Aging, 107, 42-52. Elsevier Inc.
Cortical atrophy is an early feature of Alzheimers acute accent disease (AD). The biological processes associated with variability in cortical thickness remain largely unknown. We studied 220 cerebrospinal fluid (CSF) proteins to evaluate biological
APOE ε4 gene dose effect on imaging and blood biomarkers of glial reactivity and β-amyloid pathology
Autor:
Anniina Snellman, Laura L. Ekblad, Jouni Tuisku, Mikko Koivumäki, Nicholas J. Ashton, Juan Lantero-Rodriguez, Thomas K. Karikari, Semi Helin, Marco Bucci, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne
Increased reactivity of microglia and astrocytes is known to be present at various stages of the Alzheimer’s continuum but their relationship with core Alzheimer’s disease pathology in the preclinical stages is less clear. We investigated glial r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::091d0be0c6c173f4ceb738c4ec926fd6
https://doi.org/10.1101/2022.09.19.508484
https://doi.org/10.1101/2022.09.19.508484
Autor:
Teemu Kipinoinen, Sini Toppala, Juha O. Rinne, Matti H. Viitanen, Antti M Jula, Laura L Ekblad
Publikováno v:
Neurology. 99(20)
Background and objectives:Chronic low-grade inflammation, commonly associated with cardiovascular diseases and risk factors, has been associated inconclusively with cognitive decline and dementia. The aim of our study was to evaluate whether low-grad
Publikováno v:
Alzheimer's & Dementia. 17