Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura L. Colbran"'
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers’ activity patterns: some enhancers drive expression in a single cellular context, while others are active across m
Externí odkaz:
https://doaj.org/article/3e34d2e728da46129952018e0a252c1c
Publikováno v:
GENETICS. 224
Most variants identified in human genome-wide association studies and scans for selection are non-coding. Interpretation of these variants’ effects and understanding of the way in which they contribute to phenotypic variation and adaptation in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c86ab609e2800d26536b2fc116a5268
https://doi.org/10.1093/genetics/iyad060
https://doi.org/10.1093/genetics/iyad060
Autor:
Keila Velazquez-Arcelay, Laura L. Colbran, Evonne McArthur, Colin Brand, Justin Siemann, Douglas McMahon, John A. Capra
Publikováno v:
bioRxiv
IntroductionWhen the ancestors of modern Eurasians migrated out of Africa and interbred with Eurasian archaic hominins, namely Neanderthals and Denisovans, DNA of archaic ancestry integrated into the genomes of anatomically modern humans. This proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5e4050e658664b0c11c9a006849f83
https://doi.org/10.1101/2023.02.03.527061
https://doi.org/10.1101/2023.02.03.527061
Alternative splicing contributes to adaptation and divergence in many species. However, it has not been possible to directly compare splicing between modern and archaic hominins. Here, we unmask the recent evolution of this previously unobservable re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a66bb7a819e3003f7b80cb152437f
https://doi.org/10.1101/2022.08.02.502533
https://doi.org/10.1101/2022.08.02.502533
Publikováno v:
Annual review of genomics and human genetics, vol 23, iss 1
Ancient DNA provides a powerful window into the biology of extant and extinct species, including humans’ closest relatives: Denisovans and Neanderthals. Here, we review what is known about archaic hominin phenotypes from genomic data and how those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1126c515a7ce37b110d863963dc6f80
https://escholarship.org/uc/item/6rx6639n
https://escholarship.org/uc/item/6rx6639n
Publikováno v:
Genome Biology and Evolution
As humans populated the world, they adapted to many varying environmental factors, including climate, diet, and pathogens. Because many of these adaptations were mediated by multiple noncoding variants with small effects on gene regulation, it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca43f48e3ec7fb9f69ea19db2f9e4b1
https://doi.org/10.1093/gbe/evab237
https://doi.org/10.1093/gbe/evab237
As humans spread throughout the world, they adapted to variation in many environmental factors, including climate, diet, and pathogens. Because many of these adaptations were likely mediated by multiple non-coding variants with small effects on gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018250ee3ba7327b9405ebbf72c8e4f0
https://doi.org/10.1101/2021.07.05.451164
https://doi.org/10.1101/2021.07.05.451164
Publikováno v:
Genetics. 211(4)
Enhancers and promoters both regulate gene expression by recruiting transcription factors (TFs); however, the degree to which enhancer vs. promoter activity is due to differences in their sequences or to genomic context is the subject of ongoing deba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f974d27ba88c17ae3da073cf0811f65a
https://pubmed.ncbi.nlm.nih.gov/30696717
https://pubmed.ncbi.nlm.nih.gov/30696717
Publikováno v:
Nat Ecol Evol
Sequencing DNA derived from archaic bones has enabled genetic comparison of Neanderthals and anatomically modern humans (AMHs), and revealed that they interbred. However, interpreting what genetic differences imply about their phenotypic differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31adc8dcb478f5a2d003c69bc755358e
https://pubmed.ncbi.nlm.nih.gov/31591491
https://pubmed.ncbi.nlm.nih.gov/31591491
Publikováno v:
BMC Genomics
BMC Genomics, Vol 18, Iss 1, Pp 1-11 (2017)
BMC Genomics, Vol 18, Iss 1, Pp 1-11 (2017)
Background Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers’ activity patterns: some enhancers drive expression in a single cellular context, while others are active across many. Sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ec2d17951d7c5a1053cfee269c8424
http://europepmc.org/articles/PMC5512948
http://europepmc.org/articles/PMC5512948