Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Laura L. Baxter"'
Autor:
Laura L. Baxter, Dawn E. Watkins-Chow, Nicholas L. Johnson, Nicole Y. Farhat, Frances M. Platt, Ryan K. Dale, Forbes D. Porter, William J. Pavan, Jorge L. Rodriguez-Gil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Niemann–Pick disease type C1 (NPC1) is a rare, prematurely fatal lysosomal storage disorder which exhibits highly variable severity and disease progression as well as a wide-ranging age of onset, from perinatal stages to adulthood. This he
Externí odkaz:
https://doaj.org/article/ca15cd7d85e544589362b1541d47b189
Autor:
Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, NISC Comparative Sequencing Program, Stacie K. Loftus, William J. Pavan
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyance from the cell memb
Externí odkaz:
https://doaj.org/article/ce2c137f69cd42e7919eb66ea82b21b5
Autor:
Jorge L. Rodriguez-Gil, Dawn E. Watkins-Chow, Laura L. Baxter, Gene Elliot, Ursula L. Harper, Stephen M. Wincovitch, Julia C. Wedel, Arturo A. Incao, Mylene Huebecker, Frederick J. Boehm, William S. Garver, Forbes D. Porter, Karl W. Broman, Frances M. Platt, William J. Pavan
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Niemann-Pick disease type C1 (NPC1) is a rare, fatal neurodegenerative disorder characterized by lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurol
Externí odkaz:
https://doaj.org/article/ef50034038734837b8a67902b9084e8d
Autor:
William J. Pavan, Wei Zheng, John C. McKew, Art Incao, Juan J. Marugan, Jingbo Xiao, Laura L. Baxter
Publikováno v:
Nutrients, Vol 4, Iss 6, Pp 467-490 (2012)
Vitamin E isoforms are essential nutrients that are widely used as dietary supplements and therapeutic agents for a variety of diseases. However, their pharmacokinetic (PK) properties remain poorly characterized, and high dosage animal studies may pr
Externí odkaz:
https://doaj.org/article/d748063a091c4d7ca7cc2033801f300a
Autor:
Nisc Comparative Sequencing Program, Jorge L Rodriguez-Gil, Steven R Carlson, Kerri L. Wallom, William J. Pavan, Dawn E. Watkins-Chow, Forbes D. Porter, Arturo Incao, Laura L. Baxter, Ryan K. Dale, Frances M. Platt, Cristin Davidson, Nicole Y. Farhat, Nicholas L Johnson
Publikováno v:
Hum Mol Genet
The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological
Autor:
Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005682 (2015)
Externí odkaz:
https://doaj.org/article/104fd857238b4b8189cbe2fd22c7a629
Autor:
Laura L, Baxter, Dawn E, Watkins-Chow, Nicholas L, Johnson, Nicole Y, Farhat, Frances M, Platt, Ryan K, Dale, Forbes D, Porter, William J, Pavan, Jorge L, Rodriguez-Gil
Publikováno v:
Scientific reports. 12(1)
Niemann-Pick disease type C1 (NPC1) is a rare, prematurely fatal lysosomal storage disorder which exhibits highly variable severity and disease progression as well as a wide-ranging age of onset, from perinatal stages to adulthood. This heterogeneity
Autor:
Hideji Fujiwara, Viviana Gradinaru, Tansy Gu, Benjamin E. Deverman, Xuntian Jiang, Arturo Incao, Jorge L. Rodriguez-Gil, Laura L. Baxter, Charles P. Venditti, Keith Beadle, Cristin Davidson, Randy J. Chandler, Daniel S. Ory, William J. Pavan, Alana L. Gibson
Publikováno v:
Life Science Alliance
This work highlights the importance of CNS transduction for treatment of neurological diseases, a finding with significant clinical implications considering the long-lasting effects of gene therapy.
Niemann–Pick C1 disease (NPC1) is a rare, fa
Niemann–Pick C1 disease (NPC1) is a rare, fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf252833fb091e6c917134085a2d37c
https://resolver.caltech.edu/CaltechAUTHORS:20210930-210049351
https://resolver.caltech.edu/CaltechAUTHORS:20210930-210049351
Autor:
Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003094 (2013)
The ribosome is an evolutionarily conserved organelle essential for cellular function. Ribosome construction requires assembly of approximately 80 different ribosomal proteins (RPs) and four different species of rRNA. As RPs co-assemble into one mult
Externí odkaz:
https://doaj.org/article/8fe6fb4f16a946d0a4157894bf410bd8
Autor:
Laura L. Baxter, Stephen Wincovitch, Dawn E. Watkins-Chow, William J. Pavan, Julia C. Wedel, Frances M. Platt, William S. Garver, Arturo Incao, Frederick J. Boehm, Mylene Huebecker, Ursula Harper, Gene Elliot, Jorge L. Rodriguez-Gil, Forbes D. Porter, Karl W. Broman
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Disease Models & Mechanisms
Disease Models & Mechanisms
Niemann-Pick disease type C1 (NPC1) is a rare, fatal neurodegenerative disorder characterized by lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurol