Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Laura L Stafman"'
Autor:
Laura V Bownes, Adele P Williams, Raoud Marayati, Laura L Stafman, Hooper Markert, Colin H Quinn, Nikita Wadhwani, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0246244 (2021)
Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival. Enhancer of Zeste Homolog 2 (EZH2) is known to play a key role in supporting the m
Externí odkaz:
https://doaj.org/article/00f6cc5570544d52be7e472249944929
Autor:
Laura L Stafman, Adele P Williams, Raoud Marayati, Jamie M Aye, Jerry E Stewart, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214469 (2019)
Despite an increase in incidence, treatments for hepatoblastoma remain virtually unchanged for the past 20 years, emphasizing the need for novel therapeutics. FTY720 (fingolimod) is an immunomodulator approved for use in multiple sclerosis in childre
Externí odkaz:
https://doaj.org/article/ca19d782775f4addb86b63daed0b25c9
Autor:
Hannah Light-Olson, Jan A. Niec, Theresa A. Zwaschka, Gunther Wong, Daniel Ragheb, Joseph Oros, Hernan Correa, Monica E. Lopez, Laura L. Stafman, Harold N. Lovvorn
Publikováno v:
Journal of Pediatric Surgery. 58:702-707
Autor:
Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 200-208 (2019)
Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumo
Externí odkaz:
https://doaj.org/article/50eba423670a4f4380c1edd4eb9fdaa0
Autor:
Adele P. Williams, Evan F. Garner, Alicia M. Waters, Laura L. Stafman, Jamie M. Aye, Hooper Markert, Jerry E. Stewart, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 1, Pp 84-95 (2019)
High-risk neuroblastoma continues to carry a poor prognosis. Nearly 50% of these tumors relapse following extensive treatment regimens. Protein phosphatase 2A (PP2A), a tumor suppressor, has been shown to be downregulated in many human cancers via mu
Externí odkaz:
https://doaj.org/article/e301bf95fdb34b2097d8ae0defd2aedc
Autor:
Alicia M. Waters, Laura L. Stafman, Evan F. Garner, Smitha Mruthyunjayappa, Jerry E. Stewart, Gregory K. Friedman, Jennifer M. Coleman, James M. Markert, G. Yancey Gillespie, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 9, Iss 5, Pp 419-430 (2016)
Rhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the most common sarcoma of childhood. Despite multidrug chemotherapy regimens, surgical intervention, and radiation treatment, outcomes remain poor, especially in advanced disease, and nov
Externí odkaz:
https://doaj.org/article/6e4edd8f93794346a21f1fb0ce62b1fe
Autor:
Alicia M. Waters, Laura L. Stafman, Evan F. Garner, Smitha Mruthyunjayappa, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 9, Iss 4, Pp 263-273 (2016)
Despite the tremendous advances in the treatment of childhood solid tumors, rhabdomyosarcoma (RMS) continues to provide a therapeutic challenge. Children with metastatic or relapsed disease have a disease-free survival rate under 30%. Focal adhesion
Externí odkaz:
https://doaj.org/article/b5bd3aaff2064b53b27bfa1b1025c3f5
Autor:
Raoud Marayati, Janet Julson, Laura V. Bownes, Colin H. Quinn, Laura L. Stafman, Andee M. Beierle, Hooper R. Markert, Sara C. Hutchins, Jerry E. Stewart, David K. Crossman, Anita B. Hjelmeland, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle
Publikováno v:
Clinicalexperimental metastasis. 39(6)
Patients presenting with metastatic hepatoblastoma have limited treatment options and survival rates as low as 25%. We previously demonstrated that Proviral Integration site in Maloney murine leukemia virus 3 (PIM3) kinase promotes tumorigenesis and
Autor:
Adele P. Williams, Laura L. Stafman, Kimberly Whelan, Karina Yoon, Changchun Ren, Jerry E. Stewart, Elizabeth A. Beierle, Jamie M. Aye, Elizabeth Mroczek-Musulman
Publikováno v:
J Pediatr Surg
BACKGROUND: Patient derived xenografts (PDXs) provide a unique opportunity for investigators to study tumor cell activity, response to therapeutics, and resistance patterns without exposing the human patient to experimental compounds, and thereby pla
Autor:
Joshua C. Anderson, Caroline D. Goolsby, Kimberly Whelan, Elizabeth Mroczek-Musulman, Jamie M. Aye, Jerry E. Stewart, Raoud Marayati, Elizabeth A. Beierle, Evan F. Garner, Hooper R. Markert, Adele P. Williams, Colin H. Quinn, Christopher D. Willey, Karina J. Yoon, Mary G. Waldrop, Laura L. Stafman, Smitha Mruthyunjayappa
Publikováno v:
Oncotarget
Aggressive therapies for patients with metastatic Wilms tumor (WT) with subsequent severe late effects warrant the search for novel therapies. The role of focal adhesion kinase (FAK), a non-receptor tyrosine kinase important in pediatric solid tumor