Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Laura Knipe"'
Autor:
Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Török, Matthew J. Hannah, Justin E. Molloy, Tom Carter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads rapidly across the plasma membrane and then becomes immobilized and better-suited to leucocyte capture.
Externí odkaz:
https://doaj.org/article/432e60a79f5b4b69a0d8124022f3c9bb
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108093 (2014)
Inflammatory chemokines can be selectively released from Weibel-Palade bodies (WPBs) during kiss-and-run exocytosis. Such selectivity may arise from molecular size filtering by the fusion pore, however differential intra-WPB cargo re-mobilisation fol
Externí odkaz:
https://doaj.org/article/89802bd005ed4503bb571bebce0f8508
Autor:
Lindsay Hewlett, Gregor Zupančič, Gregory Mashanov, Laura Knipe, David Ogden, Matthew J Hannah, Tom Carter
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27314 (2011)
Weibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca(2+)-driven WPB exocytosis is not known, although indirect evidence suggests that WPB exocytosi
Externí odkaz:
https://doaj.org/article/f8f509aeaad34a1f8ebed4440b2573f7
Autor:
Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Török, Matthew J. Hannah, Justin E. Molloy, Tom Carter
Publikováno v:
Nature communications. 13(1)
In response to vascular damage, P-selectin molecules are secreted onto the surface of cells that line our blood vessels. They then serve as mechanical anchors to capture leucocytes from the blood stream. Here, we track individual P-selectin molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62fcd2184d31de1b188a7882415ef57
https://pubmed.ncbi.nlm.nih.gov/35641503
https://pubmed.ncbi.nlm.nih.gov/35641503
Autor:
Laura Knipe, Ana Violeta Fonseca, Peter B. Rosenthal, Jack Turner, James Streetley, Tom Carter, Nikolai I. Kiskin
Weibel-Palade bodies (WPBs) are secretory granules that contain von Willebrand factor and P-selectin, molecules that regulate hemostasis and inflammation, respectively. The presence of CD63/LAMP3 in the limiting membrane of WPBs has led to their clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5dc05dd03c53f46158e69ea180ae50
Autor:
Justin E. Molloy, Tatiana A. Nenasheva, Michelle Peckham, Gregory I. Mashanov, Francine Parker, Laura Knipe
Publikováno v:
Biophysical Journal. 118:607a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5180f60c1a8d6ac50aa26dc15d4392
https://doi.org/10.1016/j.bpj.2019.11.3277
https://doi.org/10.1016/j.bpj.2019.11.3277
Autor:
Athinoula Meli, Matthew J. Hannah, Tom Carter, Victor Babich, Lindsay Hewlett, John Dempster, Laura Knipe
Publikováno v:
Journal of Biological Chemistry. 284:12459-12468
Proteins secreted from Weibel-Palade bodies (WPBs) play important roles in regulating inflammatory and hemostatic responses. Inflammation is associated with the extracellular acidification of tissues and blood, conditions that can alter the behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ef4cf8256b8c14887c1c0ac5d6bb8d
https://doi.org/10.1074/jbc.m809235200
https://doi.org/10.1074/jbc.m809235200
Autor:
Victor Babich, Matthew J. Hannah, Paul Skehel, Muriel Erent, Athinoula Meli, Gregor Zupančič, Tom Carter, N Moisoi, David Ogden, Laura Knipe
Publikováno v:
The Journal of Physiology. 583:195-212
The rate, concentration dependence and extent of histamine-evoked Weibel–Palade body (WPB) exocytosis were investigated with time-resolved fluorescence microscopy in cultured human umbilical vein endothelial cells expressing WPB-targeted chimeras o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b7f6bdf6434be22533c0cb7096c421
https://doi.org/10.1113/jphysiol.2007.132993
https://doi.org/10.1113/jphysiol.2007.132993
Publikováno v:
Journal of Biological Chemistry. 280:22827-22830
The time course for cell surface loss of von Willebrand factor (VWF) and the propolypeptide of VWF (proregion) following exocytosis of individual Weibel-Palade bodies (WPBs) from single human endothelial cells was analyzed. Chimeras of enhanced green
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743aa4c81bd333625c3a30ce1116ac5e
https://doi.org/10.1074/jbc.m412547200
https://doi.org/10.1074/jbc.m412547200
Autor:
Matthew J. Hannah, Lindsay Hewlett, Gregor Zupančič, Laura Knipe, Tom Carter, Gregory I. Mashanov, David Ogden
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27314 (2011)
PLoS ONE, Vol 6, Iss 11, p e27314 (2011)
Background: Weibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca2+-driven WPB exocytosis is not known, although indirect evidence suggests that WPB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e6c30461b11a4429e338c39a455486
http://europepmc.org/articles/PMC3214045
http://europepmc.org/articles/PMC3214045