Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Laura Kibuuka"'
Autor:
Nikolaus R McFarland, Hemi Dimant, Laura Kibuuka, Darius Ebrahimi-Fakhari, Cody A Desjardins, Karin M Danzer, Michael Danzer, Zhanyun Fan, Michael A Schwarzschild, Warren Hirst, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86048 (2014)
Hsp90 inhibitors such as geldanamycin potently induce Hsp70 and reduce cytotoxicity due to α-synuclein expression, although their use has been limited due to toxicity, brain permeability, and drug design. We recently described the effects of a novel
Externí odkaz:
https://doaj.org/article/c78d459ac5334556a26f1b1a94649c90
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92098 (2014)
PLoS ONE
PLoS ONE
Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein. Accumulating evidence demonstrates the association of smaller oligomeric aggregates to disease e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8382874915fd3d38b8d512f6eee37b94
https://doi.org/10.1371/journal.pone.0092098
https://doi.org/10.1371/journal.pone.0092098
Autor:
Suneil K. Kalia, Hemi Dimant, Darius Ebrahimi-Fakhari, Bradley T. Hyman, Laura Kibuuka, Liya N Zhu, Lorraine V. Kalia, Nikolaus R. McFarland, Pamela J. McLean, Zhanyun Fan
Publikováno v:
Acta Neuropathologica Communications
Background Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a069fe168730ee431ff543ddbe4b3db2