Phagocytosis in the retina promotes local insulin production in the eye

Autor: J. Iker Etchegaray, Shannon Kelley, Kristen Penberthy, Laura Karvelyte, Yosuke Nagasaka, Sofia Gasperino, Soumen Paul, Vikram Seshadri, Michael Raymond, Ana Royo Marco, Jonathan Pinney, Marta Stremska, Brady Barron, Christopher Lucas, Nishikant Wase, Yong Fan, Emil Unanue, Bijoy Kundu, Tal Burstyn-Cohen, Justin Perry, Jayakrishna Ambati, Kodi S. Ravichandran

Publikováno v: Etchegaray, J I, Kelley, S, Penberthy, K K, Karvelyte, L, Nagasaka, Y, Gasperino, S, Paul, S, Seshadri, V, Raymond, M H, Marco, A R, Pinney, J, Stremska, M E, Barron, B, Lucas, C D, Wase, N, Fan, Y, Unanue, E, Kundu, B, Burstyn-Cohen, T, Perry, J S A, Jayakrishna, A & Ravichandran, K S 2023, ' Phagocytosis in the retina promotes local insulin production in the eye ', Nature Metabolism . https://doi.org/10.1038/s42255-022-00728-0

The retina is highly metabolically active, relying on glucose uptake and aerobic glycolysis. Situated in close contact to photoreceptors, a key function of cells in the retinal pigment epithelium (RPE) is phagocytosis of damaged photoreceptor outer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015ab2ee76d21aacd3289ac8c786341
https://doi.org/10.1038/s42255-022-00728-0

Microbes exploit death-induced nutrient release by gut epithelial cells

Autor: Christopher B. Medina, Kelly Lemeire, Vanessa Andries, Geert van Loo, Irina Lambertz, Justin S. A. Perry, Arne Martens, Gillian Blancke, Lars Vereecke, Kodi S. Ravichandran, Laura Karvelyte, Amanda Gonçalves, Tania Løve Aaes, Christopher J. Anderson, Parul Mehrotra, Peter Vandenabeele, Farzaneh Ghazavi, Brady J. Barron

Publikováno v: Nature
NATURE

Regulated cell death is an integral part of life, and has broad effects on organism development and homeostasis1. Malfunctions within the regulated cell death process, including the clearance of dying cells, can manifest in diverse pathologies throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca5577f4bd1ddaf4429ea0467bb989c