Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Laura Karpauskaite"'
Autor:
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell prol
Externí odkaz:
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Autor:
Laura Karpauskaite, Ahmed J. Afzal, Ibrahim Chehade, Jemil Ahmed, Renu Pasricha, Mazin Magzoub, Andrew D. Hamilton, Debabrata Maity, Mona Kalmouni, Loganathan Palanikumar, Sunil Kumar, Maheen Alam, Tatiana Houhou, Gennaro Esposito, Zackary Falls, Shake Karapetyan, Yamanappa Hunashal, Ram Samudrala, Mohamed Al-Sayegh, Liaqat Ali, Sarah Hassan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
Nature Communications
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914b9d23167b4db0a4609f8d776a3030
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents†
Autor:
Madeline Howarth, Wolfgang Hoyer, Lothar Gremer, Debabrata Maity, Ruyof AlHussein, Andrew D. Hamilton, Mazin Magzoub, Sunil Kumar, Laura Karpauskaite
Publikováno v:
RSC Chemical Biology
RSC chemical biology 1(4), 225-232 (2020). doi:10.1039/D0CB00086H
RSC chemical biology 1(4), 225-232 (2020). doi:10.1039/D0CB00086H
Membrane-catalysed misfolding of islet amyloid polypeptide is associated with the death of β-cells in type II diabetes (T2D). Most active compounds so far reported require high doses for inhibition of membrane bound IAPP fibrillation. Here, we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce62f068ad95baf5c37a7fd23655a506
http://europepmc.org/articles/PMC8341728
http://europepmc.org/articles/PMC8341728
Autor:
Mazin Magzoub, Sarah Hassan, Maheen Alam, Yamanappa Hunashal, Gennaro Esposito, Mohamed Al-Sayegh, Ibrahim Chehade, Liaqat Ali, Zackary Falls, Andrew D. Hamilton, Renu Pasricha, Sunil Kumar, Laura Karpauskaite, Ahmed J. Afzal, Mona Kalmouni, Jemil Ahmed, Ram Samudrala, Debabrata Maity, Loganathan Palanikumar, Shake Karapetyan
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The vast majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa961805711ad26790abd3b96f53b97
https://doi.org/10.1101/2020.08.10.243154
https://doi.org/10.1101/2020.08.10.243154
Autor:
Palanikumar Loganathan, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Ali, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Tatiana Houhou, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Biophysical Journal. 121:300a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe04b24e5b092891b3c7e61f9e1fc2ce
https://doi.org/10.1016/j.bpj.2021.11.1253
https://doi.org/10.1016/j.bpj.2021.11.1253