Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura K. Herzog"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
García Saura et al. report a new tool, MacroGreen, to detect ADP-ribosylation by GFP fluorescence in a microplate reader, or in cells by microscopy. With superior affinity and reduced ADP-ribosyl hydrolase activity, MacroGreen is an easy to produce
Externí odkaz:
https://doaj.org/article/8fe7a8dba01b4c11be93a83d1e113985
Autor:
Thibaud J. C. Richard, Laura K. Herzog, Julia Vornberger, Aldwin Suryo Rahmanto, Olle Sangfelt, Florian A. Salomons, Nico P. Dantuma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Even though K63-linked polyubiquitin chains do not target proteins for proteasomal degradation, they play nevertheless a complementary protective role in maintaining protein homeostasis by directing malfunctioning proteins and organelles to
Externí odkaz:
https://doaj.org/article/c16e088089de40dbade83e4e69e958b1
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Communications Biology
Communications Biology
Enzymes in the PARP family partake in the regulation of vital cellular signaling pathways by ADP-ribosylating their targets. The roles of these signaling pathways in disease development and the de-regulation of several PARP enzymes in cancer cells ha
Autor:
Lara G. Merino, Anne Simonsen, Shanshan Xu, Florian A. Salomons, Maria E. Gierisch, Laura K. Herzog, Martin Haraldsson, Hanna Uvell, Nico P. Dantuma, Anna-Lena Gustavsson, Henriette Stoy, Michaela Vallin, Tatiana A. Giovannucci, Weixing Qian, Alf Håkon Lystad
Publikováno v:
Autophagy. 18(7)
The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, these complem
Autor:
Laura K. Herzog, Magdalena B. Rother, Ulrike Kühbacher, Martijn S. Luijsterburg, Haico van Attikum, Rashmi G. Shah, Henriette Stoy, Girish M. Shah, Nico P. Dantuma, Annika Pfeiffer
Publikováno v:
Journal of Cell Science, 134(3). COMPANY BIOLOGISTS LTD
DNA damage-induced SUMOylation serves as a signal for two antagonizing proteins that both stimulate repair of DNA double-strand breaks (DSBs). Here, we demonstrate that the SUMO-dependent recruitment of the deubiquitylating enzyme ataxin-3 to DSBs, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59659e8781fbba2c9bbf54ca8176fa63
https://hdl.handle.net/1887/3213867
https://hdl.handle.net/1887/3213867
Autor:
Julia Vornberger, Thibaud J. C. Richard, Olle Sangfelt, Nico P. Dantuma, Laura K. Herzog, Aldwin Suryo Rahmanto, Florian A. Salomons
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Even though K63-linked polyubiquitin chains do not target proteins for proteasomal degradation, they play nevertheless a complementary protective role in maintaining protein homeostasis by directing malfunctioning proteins and organelles to inclusion
Publikováno v:
Aging (Albany NY)
Autor:
Nico P, Dantuma, Laura K, Herzog
Publikováno v:
Advances in experimental medicine and biology. 1233
Machado-Joseph disease (MJD), also known as Spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant inheritable neurodegenerative disorder. After a long pre-symptomatic period, this late-onset disease progressively disables patients and typica
Autor:
Anne Simonsen, Alf Håkon Lystad, Thorsten Hoppe, Éva Kevei, Annika Pfeiffer, Laura K. Herzog, Christian Bindesbøll, Ricardo Marchante, Claudia Böttcher, Maria E. Gierisch, Florian A. Salomons, Nico P. Dantuma
Publikováno v:
Aging Cell
The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, however
Autor:
Laura K. Herzog, Klára Ács, Annika Pfeiffer, Martijn S. Luijsterburg, Claudia Böttcher, Florian A. Salomons, Angela Helfricht, Haico van Attikum, Nico P. Dantuma, Melania Minoia, Wouter W. Wiegant
Publikováno v:
The EMBO Journal. 36:1066-1083
The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response.