Výsledky vyhledávání - "Laura K. Henchey"

High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex

Autor: Jason R. Porter, Indraneel Ghosh, Paramjit S. Arora, Laura K. Henchey

Publikováno v: ChemBioChem. 11:2104-2107

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308a8381c3748db89d28d2b03267ebbf
https://doi.org/10.1002/cbic.201000378

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Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

Autor: Paramjit S. Arora, Bogdan Olenyuk, Swati Kushal, Ross N. Chapman, Laura K. Henchey, Ramin Dubey

Publikováno v: Journal of the American Chemical Society. 132:941-943

Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the treatment of neovascularization in cancers. We report a stabilized alpha-helix designed to tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e941001551f9db20146376462a53a6a3
https://doi.org/10.1021/ja9082864

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Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

Autor: Paramjit S. Arora, Brooke Bullock Lao, Bogdan Olenyuk, Laura K. Henchey, Ramin Dubey, Nathaniel J. Traaseth, Swati Kushal, Hanah Mesallati

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 110(39)

Selective blockade of gene expression by designed small molecules is a fundamental challenge at the interface of chemistry, biology, and medicine. Transcription factors have been among the most elusive targets in genetics and drug discovery, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bd6ff63b573439edc8de763f1efef0
https://pubmed.ncbi.nlm.nih.gov/24019500

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Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

Autor: Katherine M. Block, Hui Wang, Nathan W. Polaske, Zuohe Song, Laura K. Henchey, Joshua Makhoul, Swati Kushal, Bogdan Olenyuk, Lajos Szabo, Ramin Dubey, Emmanuelle J. Meuillet, Csaba F. László

Publikováno v: Journal of the American Chemical Society. 131(50)

Selective blockade of hypoxia-inducible gene expression by designed small molecules would prove valuable in suppressing tumor angiogenesis, metastasis and altered energy metabolism. We report the design, synthesis, and biological evaluation of a dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866e07c4ade783e1c069db265d1537c
https://pubmed.ncbi.nlm.nih.gov/20000859

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Contemporary Strategies for the Stabilization of Peptides in the α-Helical Conformation

Autor: Andrea L. Jochim, Paramjit S. Arora, Laura K. Henchey

Herein we review contemporary synthetic and protein design strategies to stabilize the alpha-helical motif in short peptides and miniature proteins. Advances in organometallic catalyst design, specifically for the olefin metathesis reaction, enable t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dd5d27cda9ed046d6421102ff89cf9
https://europepmc.org/articles/PMC2650020/

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Correction to Inhibition of Hypoxia Inducible Factor 1–Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

Autor: Bogdan Olenyuk, Ramin Dubey, Paramjit S. Arora, Laura K. Henchey, Swati Kushal, Ross N. Chapman

Publikováno v: Journal of the American Chemical Society. 134:8000-8000

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfe915065116609007b372bf6e58c39
https://doi.org/10.1021/ja302676m

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Abstract 289: Hydrogen bond surrogate (HBS) helices as orthosteric regulator of hypoxia inducible transcription

Autor: Swati Kushal, Paramjit S. Arora, Bogdan Olenyuk, Laura K. Henchey, Brooke N. Bullock

Publikováno v: Cancer Research. 72:289-289

Hypoxia-Inducible Factor (HIF-1) is a heterodimeric transcriptional activator which plays a critical role in tumorigenesis and therefore is an important therapeutic target. Transcriptional activation of HIF-1 is known to involve the interaction betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b6e0833822e4d070be8be3d359e0ee8
https://doi.org/10.1158/1538-7445.am2012-289

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Synthesis and Characterization of Aldol Condensation Products from Unknown Aldehydes and Ketones

Autor: Nicholas G. Angelo, Adam Waxman, Laura K. Henchey, Donald J. Wink, James W. Canary, Paramjit S. Arora

Publikováno v: Journal of Chemical Education. 84:1816

An experiment for the undergraduate chemistry laboratory in which students perform the aldol condensation on an unknown aldehyde and an unknown ketone is described. The experiment involves the use of techniques such as TLC, column chromatography, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d555f2feecd08809100eedb7b642f13
https://doi.org/10.1021/ed084p1816

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