Výsledky vyhledávání - "Laura K. Antos"

Nanomolar ouabain increases NCX1 expression and enhances Ca2+signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?

Autor: Laura K. Antos, Cristina I. Linde, Mordecai P. Blaustein, Vera A. Golovina

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 303:H784-H794

The mechanisms by which NaCl raises blood pressure (BP) in hypertension are unresolved, but much evidence indicates that endogenous ouabain is involved. In rodents, arterial smooth muscle cell (ASMC) Na+pumps with an α2-catalytic subunit (ouabain EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fb706f6137e8650ee6df5b29382c40
https://doi.org/10.1152/ajpheart.00399.2012

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Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

Autor: W. Gil Wier, Kenneth D. Philipson, Ling Chen, Michael I. Kotlikoff, Mordecai P. Blaustein, Laura K. Antos, Jin Zhang, Takahiro Iwamoto, Chongyu Ren, Luis Fernando Santana, Manuel F. Navedo, Stephen P. Kinsey, Donald R. Matteson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 298:H1472-H1483

Mice with smooth muscle (SM)-specific knockout of Na+/Ca2+ exchanger type-1 (NCX1SM−/−) and the NCX inhibitor, SEA0400, were used to study the physiological role of NCX1 in mouse mesenteric arteries. NCX1 protein expression was greatly reduced in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbb6486d1c7883529309f4c4505d40a
https://doi.org/10.1152/ajpheart.00964.2009

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Adenine nucleotides decrease the apparentKmof endogenous natriuretic peptide receptors for GTP

Autor: Lincoln R. Potter, Laura K. Antos

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 293:E1756-E1763

Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ATP increases the activity of these receptors by an unknown mechanism. We recently reported that a nonhydrolyzable form of ATP, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53e656341ad1a6d80332c90e4e338db
https://doi.org/10.1152/ajpendo.00321.2007

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Calcium-dependent Dephosphorylation Mediates the Hyperosmotic and Lysophosphatidic Acid-dependent Inhibition of Natriuretic Peptide Receptor-B/Guanylyl Cyclase-B

Autor: Lincoln R. Potter, Regine Potthast, Laura K. Antos, Jonathan S. Marchant, Sarah E. Abbey-Hosch, Michaela Kuhn

Publikováno v: Journal of Biological Chemistry. 279:48513-48519

C-type natriuretic peptide binding to natriuretic peptide receptor-B (NPR-B) stimulates cGMP synthesis, which regulates vasorelaxation, cell proliferation, and bone growth. Here, we investigated the mechanistic basis for hyperosmotic and lysophosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae743aecda61d605fe2bf07bb75b32c2
https://doi.org/10.1074/jbc.m408247200

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Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications

Autor: Deborah M. Dickey, Lincoln R. Potter, Laura K. Antos, Andrea R. Yoder, Darcy R. Flora

Publikováno v: cGMP: Generators, Effectors and Therapeutic Implications ISBN: 9783540689607

Natriuretic peptides are a family of three structurally related hormone/ paracrine factors. Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac atria and ventricles, respectively. ANP signals in an endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2cdc2b86c58f1f5a8467e5d21e039e
https://pubmed.ncbi.nlm.nih.gov/19089336

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ATP‐Independent Activation of Natriuretic Peptide Receptors

Autor: Darcy R. Flora, Sarah E. Abbey-Hosch, Lincoln R. Potter, Laura K. Antos

Publikováno v: The FASEB Journal. 20

Natriuretic peptide receptor A (NPR-A) is an essential cardiovascular regulator that is stimulated by atrial natriuretic peptide and brain natriuretic peptide, whereas natriuretic peptide receptor B (NPR-B) stimulates long bone growth in a C-type nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::500dba96e7fd8887aeaf8f38c59668a8
https://doi.org/10.1096/fasebj.20.5.a972

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Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize

Autor: Laura K. Antos, Danhua Fan, Lincoln R. Potter, Paula M. Bryan, Regine Potthast

Publikováno v: Molecular pharmacology. 67(1)

Natriuretic peptide receptor A (NPR-A/GC-A) and B (NPR-B/GC-B) are members of the transmembrane guanylyl cyclase family that mediate the effects of natriuretic peptides via the second messenger, cGMP. Despite numerous reports of these receptors being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0940b903fc31ab541afde55ccbe1b73
https://pubmed.ncbi.nlm.nih.gov/15459247

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ATP-independent activation of natriuretic peptide receptors

Autor: Lincoln R. Potter, Laura K. Antos, Darcy R. Flora, Sarah E. Abbey-Hosch

Publikováno v: BMC Pharmacology. 5(Suppl 1):P3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa9236ca9498cce0b39d5cbd76b90c8

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