Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Laura K, Hamilton"'
Autor:
Laura K. Hamilton, Paule E. H. M’Bra, Sophia Mailloux, Manon Galoppin, Anne Aumont, Karl J. L. Fernandes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Evidence from genetic and epidemiological studies point to lipid metabolism defects in both the brain and periphery being at the core of Alzheimer’s disease (AD) pathogenesis. Previously, we reported that central inhibition of the rate-lim
Externí odkaz:
https://doaj.org/article/727f5ff5e5f646b18dbc82d5031be3e6
Autor:
Lovatiana Andriamboavonjy, Adam MacDonald, Laura K. Hamilton, Marjorie Labrecque, Marie-Noёlle Boivin, Jason Karamchandani, Jo Anne Stratton, Martine Tetreault
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Preserving the in vivo cell transcriptome is essential for accurate profiling, yet factors during cell isolation including time ex vivo and temperature induce artifactual gene expression, particularly in stress-responsive immune cells. In th
Externí odkaz:
https://doaj.org/article/d5c5c58582384d829b016e2e2d948c81
Autor:
Laura K. Hamilton, Gaël Moquin-Beaudry, Chenicka L. Mangahas, Federico Pratesi, Myriam Aubin, Anne Aumont, Sandra E. Joppé, Alexandre Légiot, Annick Vachon, Mélanie Plourde, Catherine Mounier, Martine Tétreault, Karl J. L. Fernandes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid abnormalities are the least understood. Here, we investigate the r
Externí odkaz:
https://doaj.org/article/c4156f3f019a4fb582af55e7362fab88
Autor:
Laura K. Hamilton, Gaël Moquin-Beaudry, Chenicka L. Mangahas, Federico Pratesi, Myriam Aubin, Anne Aumont, Sandra E. Joppé, Alexandre Légiot, Annick Vachon, Mélanie Plourde, Catherine Mounier, Martine Tétreault, Karl J. L. Fernandes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9953dc3130f340d693a49140e14e055f
Autor:
Charvi Syal, Jayasankar Kosaraju, Jacob Thomas, Matthew Seegobin, Ling He, F. Jeffrey Dilworth, Anne Aumont, Jing Wang, Laura K. Hamilton, Robert Zimmermann, Karl J.L. Fernandes, Sailendra Nath Sarma, Martin Parent, Fredric E. Wondisford, Alphonse Chu
Publikováno v:
Theranostics
Rationale: Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is a potential target for neurodegenerative diseases, such as Alzheimer's disease (AD). Incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0388e15be82a1770f2e26f0b2a6974cc
https://doi.org/10.7150/thno.44962
https://doi.org/10.7150/thno.44962
Autor:
Steve Lacroix, Laura K Hamilton, Alexandre Vaugeois, Stéfanny Beaudoin, Christian Breault-Dugas, Isabelle Pineau, Sébastien A Lévesque, Catherine-Alexandra Grégoire, Karl J L Fernandes
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85916 (2014)
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell pot
Externí odkaz:
https://doaj.org/article/1aa97cd7ab874964b5ee587b5eddf703
Autor:
Fanie Barnabé-Heider, Laura K. Hamilton, Anne Aumont, Karl Jl Fernandes, Pierre Ameslon, Loic M. Cochard, Sandra E. Joppé, Louis-Charles Levros
Publikováno v:
Life Science Alliance
In vivo evidence for precursors that produce neurons independent of neurosphere-forming neural stem cells suggests the adult forebrain, like the developing brain, has two distinct neurogenic pathways.
The ventricular epithelium of the adult fore
The ventricular epithelium of the adult fore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3bc8a19f732ed062afb79e10b96eb1
https://pubmed.ncbi.nlm.nih.gov/32482782
https://pubmed.ncbi.nlm.nih.gov/32482782
Autor:
Karl J.L. Fernandes, Laura K. Hamilton
Publikováno v:
Biology of the Cell. 110:6-25
Neural stem cell (NSC) activity and adult neurogenesis are physiologically relevant regulators of adult brain structure, function and repair. Given these roles, the NSC impairments observed in a wide range of neurodegenerative and psychiatric conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4402a46f23754b928dc365363aa29905
https://doi.org/10.1111/boc.201700037
https://doi.org/10.1111/boc.201700037
Autor:
Laura K, Hamilton, Karl J L, Fernandes
Publikováno v:
Biology of the cell. 110(1)
Neural stem cell (NSC) activity and adult neurogenesis are physiologically relevant regulators of adult brain structure, function and repair. Given these roles, the NSC impairments observed in a wide range of neurodegenerative and psychiatric conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78bb4b8ccef9c56bf20d30b7bf6d1544
https://pubmed.ncbi.nlm.nih.gov/28980327
https://pubmed.ncbi.nlm.nih.gov/28980327
Autor:
Laura K. Hamilton, Karl J.L. Fernandes
Publikováno v:
Stem Cell Biology and Regenerative Medicine ISBN: 9783319493428
Lipids constitute the majority of the brain’s dry mass, yet little is known about their influences on neural stem cell (NSC) biology during development, adulthood, and disease. This review focuses on “neutral” or simple lipids, most prominently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc86019748fc9010b161c7b53002d3dd
https://doi.org/10.1007/978-3-319-49343-5_5
https://doi.org/10.1007/978-3-319-49343-5_5
